Post-iontophoresis transport of ibuprofen lysine across rabbit ear skin

Nicoli, Sara; Colombo, Gaia; Bettini, Ruggero; Artusi, Mariella; Rimondi, Silvia; Rizzo, Paola; Colombo, Paolo

doi:10.1016/s0378-5173(03)00382-x

Cited by 14 publications

(6 citation statements)

References 15 publications

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“…Different strategies have been used to increase the local bioavailability of topically administered Ibuprofen. In order to increase the therapeutic efficacy of topically administered drugs, it is necessary to employ percutaneous absorption enhancer and appropriate vehicles (Brown et al, 2001;Santi et al, 2003;Chen et al, 2006;Godwin et al, 2006;Rhee et al, 2008). Hence, in this study, attempts have been made to enhance the transdermal permeation of Ibuprofen using niosomal formulation incorporated in Carbopol Õ 914 gel form.…”

Section: Introductionmentioning

confidence: 99%

Nonionic surfactant-based vesicular system for transdermal drug delivery

2014

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Objective: The objective of this study was to formulate and evaluate the Ibuprofen niosomal formulation as a transdermal drug delivery system. Materials and methods: Niosomes were prepared by a modified ethanol injection method, using Span 60, Tween 60 and Tween 65 as well as cholesterol with various cholesterol:surfactant molar ratios. The prepared vesicles were characterized for entrapment efficiency (EE), particle size, zeta potential and in vitro release study. Skin permeation studies were conducted using modified Franz diffusion cell, and excised rat skin was treated with niosomal, liposomal and conventional Carbopol 914 gel of Ibuprofen. Results and discussion: The results showed that the type of surfactant and molar ratio of cholesterol:surfactant altered the EE, size and in vitro drug release of niosomes. Higher EE was obtained with the niosomes prepared with cholesterol and Span 60 at molar ratio of 0.5:1. It has been observed that both niosomal and liposomal formulations enhanced the drug permeation and the percentage of accumulated dose in the skin compared to control conventional gel formulation. However, niosomes prepared by Span 60 and Tween 65 exhibited higher permeation and retention of Ibuprofen, respectively. Conclusion: Our results suggested that niosomal formulations could be used as a promising carrier for the Ibuprofen transdermal delivery system.

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Section: Introductionmentioning

confidence: 99%

Nonionic surfactant-based vesicular system for transdermal drug delivery

2014

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“…The iontophoretic method in this study employed optimum conditions (electrode type: anode, pH of buffer: 7.4, current intensity: ≤ 0.5 mA) which have been previously shown to enhance ACV permeation in vitro (105,106,109).…”

Section: Resultsmentioning

confidence: 99%

Transdermal Drug Delivery Systems: Skin Perturbation Devices

Brown

Traynor

Martin

et al. 2008

Methods in Molecular Biology™

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“…The reservoir function of the SC has long been established for solutes such as steroids, where continued penetration is observed for significant amounts of time after removal of donor vehicles from the skin's surface . Santi et al also observed the formation of an IBU reservoir in rat skin post‐iontophoresis after which IBU was concomitantly released for passive diffusion through skin. However, it has also been shown that the mere presence in the skin of drug alone is not always sufficient to achieve sustained permeation .…”

Section: Discussionmentioning

confidence: 99%