Post-Infectious Myocardial Infarction: Does Percutaneous Coronary Intervention Improve Outcomes? A Propensity Score-Matched Analysis

Putot, Alain; Chagué, F.; Manckoundia, Patrick; Brunel, Philippe; Beer, Jean‐Claude; Cottin, Yves; Zeller, Marianne

doi:10.3390/jcm9061608

Cited by 5 publications

(4 citation statements)

References 31 publications

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“…Our study findings are consistent with few previous studies with certain limitations [ 6 , 15 , 16 , 21 ]. Information regarding the severity of pneumonia in patients presenting to the emergency department was limited.…”

Section: Discussionsupporting

confidence: 93%

“…A prospective cohort examining the prognosis after PCI intervention in post-infection AMI concluded that PCI did not improve long-term prognosis. However, this study had a population with more serious comorbidities, and most patients required critical care [ 6 ]. In our analysis of 47,220 patients with AMI and pneumonia, 14.36% underwent PCI.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to the severity of illness, major loss of function was observed in the cohort who were treated with medication therapy. However, conclusive evidence to support PCI in patients with AMI predisposed due to pneumonia requires further prospective trials [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…A temporal pattern and degree of association between pneumonia and AMI point toward a causal relationship between the two conditions [ 6 , 7 ]. Several studies have linked the incidence of acute myocardial ischemia with pneumonia as respiratory infection leads to rising in pro-inflammatory cytokines such as c-reactive protein, interleukin-6, tumor necrosis factors-α, and interleukin-8 which increases atherosclerotic plaque instability and rupture [ 6 – 8 ]. Acute infections have also been shown to cause inflammation in coronary vasculature [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Acute Myocardial Infarction–Related Hospitalizations in Non-elderly Patients with Pneumonia: a Population-Based Study

Younis

Loh

Singh

et al. 2023

SN Compr. Clin. Med.

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The objective is to study factors that increase the likelihood of acute myocardial infarction (AMI) in hospitalized adult non-elderly patients with pneumonia compared to other medical inpatients and to understand the utilization rate of percutaneous coronary intervention (PCI) for AMI in inpatients with pneumonia and its related impact on hospitalization stay and cost. A population-based study was conducted using the Nationwide Inpatient Sample (NIS, 2019) with adult non-elderly inpatients (age 18–65 years) with a medical condition as their primary diagnosis and a co-diagnosis of pneumonia during hospitalization stay. This study sample was divided by the primary diagnosis of AMI versus other medical conditions (non-AMI). A logistic regression model was used to evaluate the odds ratio (OR) of predictors associated with AMI in patients with pneumonia. The results showed a direct relationship between increasing age and the likelihood of AMI in pneumonia inpatients with three times higher odds seen in 51–65 years of age (OR 2.95, 95% CI 2.82–3.09). The comorbidities included complicated hypertension (OR 2.84, 95% CI 2.78–2.89), diabetes with complications (OR 1.27, 95% CI 1.24–1.29), and drug abuse (OR 1.27, 95% CI 1.22–1.31) that increased the likelihood of AMI-related hospitalization. The utilization rate of surgical treatment (PCI) was 14.37% for the management of AMI in inpatients with pneumonia. Inpatients co-diagnosed with pneumonia and comorbidities such as hypertension and diabetes were more likely to be hospitalized for AMI. These at-risk patients should be considered for early risk stratification. Utilization of PCI was associated with a lower in-hospital mortality rate.

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