Post‑infectious irritable bowel syndrome after a laboratory‑proven enteritis

Iacob, Teodora; Țățulescu, D.; Lupşe, Mihaela; Dumitraşcu, Dan L.

doi:10.3892/etm.2020.9018

Cited by 10 publications

(12 citation statements)

References 41 publications

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“…As shown in Table 1 , based on data from 29 studies, 3.7% to 85.5% of subjects with AGE due to different causes developed PI-IBS; 10 - 39 this incidence rates were much higher than the development of IBS among the control population in 16 studies (0.3% to 23.3%). 10 In a recent meta-analysis, the pooled prevalence of PI-IBS was 11.5% (2,217/21,421; 95% confidence interval, 8.2 to 15.8); the prevalence was comparable in the studies reporting prevalence at 3, 6, 12, 13–59, or ≥60 months after AGE.…”

Section: Epidemiology Of Pi-ibsmentioning

confidence: 96%

“…As shown in Table 1 , infection with bacterial, viral, and protozoal agents causing AGE has been reported to be followed by PI-IBS. 11 - 39 Among bacteria, infection with organisms causing dysentery such as Shigella is more likely to result in PI-IBS than others. 10 However, recently, even bacterial pathogens that conventionally do not invade the gut mucosa, such as Vibrio cholerae are also shown to cause PI-IBS.…”

Section: Etiology and Pathogenesismentioning

confidence: 99%

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Postinfection Irritable Bowel Syndrome

Ghoshal

2022

Gut and Liver

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Following acute gastroenteritis (AGE) due to bacteria, viruses, or protozoa, a subset of patients develop new onset Rome criteria positive irritable bowel syndrome (IBS), called postinfection IBS (PI-IBS). The pooled prevalence of PI-IBS following AGE was 11.5%. PI-IBS is the best natural model that suggests that a subset of patients with IBS may have an organic basis. Several factors are associated with a greater risk of development of PI-IBS following AGE including female sex, younger age, smoking, severity of AGE, abdominal pain, bleeding per rectum, treatment with antibiotics, anxiety, depression, somatization, neuroticism, recent adverse life events, hypochondriasis, extroversion, negative illness beliefs, history of stress, sleep disturbance, and family history of functional gastrointestinal disorders (FGIDs), currently called disorder of gut-brain interaction. Most patients with PI-IBS present with either diarrhea-predominant IBS or the mixed subtype of IBS, and overlap with other FGIDs, such as functional dyspepsia is common. The drugs used to treat non-constipation IBS may also be useful in PI-IBS treatment. Since randomized controlled trials on the efficacy of drugs to treat PI-IBS are rare, more studies are needed on this issue.

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Section: Epidemiology Of Pi-ibsmentioning

confidence: 96%

Section: Etiology and Pathogenesismentioning

confidence: 99%

Postinfection Irritable Bowel Syndrome

Ghoshal

2022

Gut and Liver

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“…The prevalence of PI-IBS is approximately 4%-36% in patients with previous infectious gastroenteritis and is higher in females, young people, patients who experienced severe infections and individuals with psychological comorbidities. Moreover, some pathogens seem more predisposing than others; indeed, bacterial infections (particularly by Campylobacter , Shigella , Escherichia coli and Salmonella ) are more likely to enhance PI-IBS than viruses and other microorganisms[ 34 , 44 , 45 ]. The pathogenesis of this condition is poorly understood, but it is hypothesized that the responsible pathogenic microorganism may trigger an immunologic and inﬂammatory response with low-grade inflammation and mucosal injury, which causes the prolongation of IBS symptoms in predisposed individuals.…”

Section: Ibsmentioning

confidence: 99%

COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms

Settanni¹,

Ianiro²,

Ponziani³

et al. 2021

WJG

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In December 2019 a novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), started spreading from Wuhan city of Chinese Hubei province and rapidly became a global pandemic. Clinical symptoms of the disease range from paucisymptomatic disease to a much more severe disease. Typical symptoms of the initial phase include fever and cough, with possible progression to acute respiratory distress syndrome. Gastrointestinal manifestations such as diarrhoea, vomiting and abdominal pain are reported in a considerable number of affected individuals and may be due to the SARS-CoV-2 tropism for the peptidase angiotensin receptor 2. The intestinal homeostasis and microenvironment appear to play a major role in the pathogenesis of COVID-19 and in the enhancement of the systemic inflammatory responses. Long-term consequences of COVID-19 include respiratory disturbances and other disabling manifestations, such as fatigue and psychological impairment. To date, there is a paucity of data on the gastrointestinal sequelae of SARS-CoV-2 infection. Since COVID-19 can directly or indirectly affect the gut physiology in different ways, it is plausible that functional bowel diseases may occur after the recovery because of potential pathophysiological alterations (dysbiosis, disruption of the intestinal barrier, mucosal microinflammation, post-infectious states, immune dysregulation and psychological stress). In this review we speculate that COVID-19 can trigger irritable bowel syndrome and we discuss the potential mechanisms.

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“…14,17 In the study by Lacob and colleagues, comparing patients with PI-IBS with a control group showed that women had a 4.4-fold increased odds of developing PI-IBS (versus men). 20 This can be because of the increased level of psychological disorders in women, including depression, anxiety, and stress, which have been identified as important factors predisposing the patient to PI-IBS. 21 Younger age has also been introduced as a predisposing factor for PI-IBS, and age > 50-60 years old has been suggested to protect against PI-IBS, possibly because of the poorer activation of the immune system.…”

Section: Discussionmentioning

confidence: 99%

Post-Infectious Irritable Bowel Syndrome after an Epidemic of Gastroenteritis in South of Iran

Sharifi

Safarpour

Barati‐Boldaji

et al. 2022

Middle East J Dig Dis

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Background: Irritable bowel syndrome (IBS) is a chronic disabling condition without a well-defined etiology. Infectious gastroenteritis (IGE) has been linked to this syndrome. There are few data from Iran on this association. Methods: In August 2018, an epidemic of IGE caused by Escherichia coli occurred in a village in the west of Shiraz in southern Iran. One year after this epidemic, the occurrence of IBS was surveyed in those who suffered from IGE based on Rome IV criteria in that village. Results: Of 179 patients included in the present study, 17 patients (9.5%) had post-infectious (PI)-IBS. There was no difference in age, sex, antibiotic use, hematochezia, duration of infectious diarrhea, fever, and weight loss at the time of IGE between those with and without PI-IBS. Conclusion: PI-IBS is common after IGE, but no risk factor for its development was found in this study.

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Post‑infectious irritable bowel syndrome after a laboratory‑proven enteritis

Cited by 10 publications

References 41 publications

Postinfection Irritable Bowel Syndrome

Postinfection Irritable Bowel Syndrome

COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms

Post-Infectious Irritable Bowel Syndrome after an Epidemic of Gastroenteritis in South of Iran

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