Post-Infectious Demyelinating Polyneuropathy Secondary to Covid-19 Infection

Patti, Ravikaran; Duarte, Claudia De Araujo; Dalsania, Nishil; Gonuguntla, Varun Tej; Atuaka, Christiana; Gomes, B. De Brito; Somal, Navjot; Seneviratne, Chaminda Jayampath

doi:10.1016/j.chest.2021.07.626

Cited by 2 publications

(1 citation statement)

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“…These findings suggest that peripheral nervous system damage may be a common feature of MIS-C. Interestingly, both central and peripheral nervous system involvement in MIS-C have been previously described 49,50 , although these clinical manifestations are infrequent. Notably, peripheral nervous system damage has also been documented in pediatric and adult COVID-19 and in post-acute sequelae such as long COVID [51][52][53] . Future studies are needed to elucidate the mechanisms and clinical spectrum of neurologic involvement in acute MIS-C and their association with long-term neurodevelopment.…”

Section: Discussionmentioning

confidence: 99%

WITHDRAWN: Nucleic acid biomarkers of immune response and cell and tissue damage in COVID-19 and MIS-C

Loy

Sotomayor-González

Servellita

et al. 2022

Preprint

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Differential host responses in coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) remain poorly characterized. Here we use next-generation sequencing to longitudinally analyze blood samples from pediatric patients with acute COVID-19 (n=70) or MIS-C (n=141) across three hospitals. Profiling of plasma cell-free nucleic acids uncovers distinct signatures of cell injury and death between these two disease states, with increased heterogeneity and multi-organ involvement in MIS-C encompassing diverse cell types such as endothelial and neuronal Schwann cells. Whole blood RNA profiling reveals upregulation of similar pro-inflammatory signaling pathways in COVID-19 and MIS-C, but also MIS-C specific downregulation of T cell-associated pathways. Profiling of plasma cell-free RNA and whole blood RNA in paired samples yields different yet complementary signatures for each disease state. Our work provides a systems-level, multi-analyte view of immune responses and tissue damage in COVID-19 and MIS-C and informs the future development of new disease biomarkers.

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