Post-Infectious Autoimmunity in the Central (CNS) and Peripheral (PNS) Nervous Systems: An African Perspective

Abstract

The direct impact and sequelae of infections in children and adults result in significant morbidity and mortality especially when they involve the central (CNS) or peripheral nervous system (PNS). The historical understanding of the pathophysiology has been mostly focused on the direct impact of the various pathogens through neural tissue invasion. However, with the better understanding of neuroimmunology, there is a rapidly growing realization of the contribution of the innate and adaptive host immune responses in the pathogenesis of many CNS and PNS diseases.The balance between the protective and pathologic sequelae of immunity is fragile and can easily be tipped towards harm for the host. The matter of immune privilege and surveillance of the CNS/PNS compartments and the role of the blood-brain barrier (BBB) and blood nerve barrier (BNB) makes this even more complex. Our understanding of the pathogenesis of many post-infectious manifestations of various microbial agents remains elusive, especially in the diverse African setting. Our exploration and better understanding of the neuroimmunology of some of the infectious diseases that we encounter in the continent will go a long way into helping us to improve their management and therefore lessen the burden.Africa is diverse and uniquely poised because of the mix of the classic, well described, autoimmune disease entities and the specifically “tropical” conditions. This review explores the current understanding of some of the para- and post-infectious autoimmune manifestations of CNS and PNS diseases in the African context. We highlight the clinical presentations, diagnosis and treatment of these neurological disorders and underscore the knowledge gaps and perspectives for future research using disease models of conditions that we see in the continent, some of which are not uniquely African and, where relevant, include discussion of the proposed mechanisms underlying pathogen-induced autoimmunity. This review covers the following conditions as models and highlight those in which a relationship with COVID-19 infection has been reported: a) Acute Necrotizing Encephalopathy; b) Measles-associated encephalopathies; c) Human Immunodeficiency Virus (HIV) neuroimmune disorders, and particularly the difficulties associated with classical post-infectious autoimmune disorders such as the Guillain-Barré syndrome in the context of HIV and other infections. Finally, we describe NMDA-R encephalitis, which can be post-HSV encephalitis, summarise other antibody-mediated CNS diseases and describe myasthenia gravis as the classic antibody-mediated disease but with special features in Africa.

Spectrum of Neurological Disorders Related to Autoimmune Diseases in Brazzaville, Congo

“…The data related to the medical history of our patients (Table 2) corroborate those reported by other researchers [19] [20] [22] [30]- [39].…”

“…Studies on neurological disorders related to autoimmune diseases are rare in Africa [21] [22]. The neurological clinico-pathological entities found in our series have also been reported in other studies conducted in sub-Saharan Africa Based on the literature, the recommended first-line treatment for acute polyradiculoneuropathy is plasmapheresis or intravenous immunoglobulin injection [20] [74].…”

“…It could be attributed to the factors mentioned in Table 2 and to vaccinations. Indeed, the literature reports that the following factors are associated with autoimmune diseases: infections and vaccinations [19] [20] [22] [30] [31]; long-term use of drugs such as some antibiotics, some antiretrovirals, cardiovascular drugs, antiepileptic drugs, slow-acting anti-inflammatory drugs, antithyroid drugs, cholesterol-lowering drugs [19] [32] [33] [34] [35]; high blood pressure [36] [37]; stigmata of autoimmunity [38] [39]; stress, lifestyle, excessive alcohol consumption, smoking and change of dietary habits [4] [20] [40] [41].…”

“…If the landscape of autoimmune diseases of the nervous system is well explored in developed countries [4] [19] [20], this is not the case in low-income countries, such as those in Africa [21] [22].…”

Cerebrospinal fluid viral etiology of patients with suspected central nervous system infections during the COVID-19 outbreak

“…As of today, Herpes virus neuroinvasive disease can also be diagnosed in CSF, establishing a correlation between its clinical and laboratory characteristics [9,10]. There are varieties of consequences that can result from viral neuro-invasion, including acute and subacute viral encephalitis, post-infectious acute disseminated encephalomyelitis, and subacute sclerosing panencephalitis, which can occur 6-10 years after initial viral infection, respectively [11]. In Alzheimer's disease and multiple sclerosis, human herpesviruses have been associated with neurodegenerative diseases [12].…”