Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators

Abstract

Our data demonstrate that radical scavengers effectively protect from hypoxia-reoxygenation injury in isolated tubular segments and that the iron chelator deferoxamine is especially a potent inhibitor of iron ion-mediated hypoxia-reoxygenation damage. Thus, inclusion of this iron chelator in organ storage solutions might improve post-transplant organ function and protect from reperfusion injury.

Multidrug donor preconditioning prevents cold liver preservation and reperfusion injury

“…With the aim to achieve the best possible organ protection by adjunct preconditioning, we included those drugs in our MDDP protocol, which have been shown in previous single-drug preconditioning studies to be successful in attenuating postischemic liver injury. These substances provide protection be exerting anti-oxidative, anti-inflammatory, and anti-apoptotic actions, or may even be characterized by a pleiotropic action profile [52], such as simvastatin [42], glycine [53,54], erythropoietin [55], and methylprednisolone [56]. The data of the present study now indicate that MDDP is capable of almost completely preventing cold I/R injury.…”

Split-Liver Procedure and Inflammatory Response: Improvement by Pharmacological Preconditioning

“…With the aim to achieve the best possible organ protection by adjunct preconditioning, we included those drugs in our HPP that have been shown in previous single-drug preconditioning studies to be successful in attenuating post-ischemic liver injury [18][19][20][21][22][23][24]. These drugs have been shown to provide protection be exerting anti-oxidative, anti-inflammatory, and anti-apoptotic actions, or may even be characterized by a pleiotropic action profile [48], such as simvastatin [49], glycine [50,51], and erythropoietin [52]. The data of the present study now indicate that HPP is capable of almost completely preventing SL procedure-induced inflammation and injury.…”

Cardiorenal Syndromes: Pathophysiology to Prevention

“…It is believed that local cellular and tissue availability of catalytic iron determines the degree and severity of organ injury in the setting of most hypoxic and other toxic insults [ 74 ]. Thus, catalytic iron may serve as both a diagnostic and therapeutic target by using iron chelators in the future for CRSs [ 75 ].…”