Post-Hatch Neuron Incorporation in The Zebra Finch Caudomedial Nidopallium (NCM) in Relation to Vocal Learning

Asik, Kemal

doi:10.14418/wes01.3.64

Cited by 2 publications

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“…In the temporal cortex of humans and monkeys, aromatase is co‐expressed with both PV and CB in neurons (Yague et al, ). In the songbird NCM, neurons with different spiking kinetics, including GABAergic interneurons, are specialized for certain aspects of auditory processing (Pinaud & Mello, ; Schneider & Woolley, ; Asik & Kirn, ; Ono, Okanoya, & Seki, ; Yanagihara & Yazaki‐Sugiyama, ) and GABAergic neurons are active when birds hear songs (Pinaud & Mello, ). Together, these observations raise the possibility that auditory‐evoked changes in the activity of GABAergic neurons are directly linked to auditory‐evoked elevations in forebrain estradiol levels (Remage‐Healey et al, ).…”

Section: Introductionmentioning

confidence: 99%

Clustered organization and region‐specific identities of estrogen‐producing neurons in the forebrain of Zebra Finches (Taeniopygia guttata)

Ikeda

Krentzel

Oliver

et al. 2017

J of Comparative Neurology

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A fast, neuromodulatory role for estrogen signaling has been reported in many regions of the vertebrate brain. Regional differences in the cellular distribution of aromatase (estrogen synthase) in several species suggest that mechanisms for neuroestrogen signaling differ between and within brain regions. A more comprehensive understanding of neuroestrogen signaling depends on characterizing the cellular identities of neurons that express aromatase. Calcium-binding proteins such as parvalbumin and calbindin are molecular markers for interneuron subtypes, and are co-expressed with aromatase in human temporal cortex. Songbirds like the zebra finch have become important models to understand the brain synthesis of steroids like estrogens and the implications for neurobiology and behavior. Here, we investigated the regional differences in cytoarchitecture and cellular identities of aromatase-expressing neurons in the auditory and sensorimotor forebrain of zebra finches. Aromatase was co-expressed with parvalbumin in the caudomedial nidopallium (NCM) and HVC shelf (proper name) but not in the caudolateral nidopallium (NCL) or hippocampus. By contrast, calbindin was not co-expressed with aromatase in any region investigated. Notably, aromatase-expressing neurons were found in dense somato-somatic clusters, suggesting a coordinated release of local neuroestrogens from clustered neurons. Aromatase clusters were also more abundant and tightly packed in the NCM of males as compared to females. Overall, this study provides new insights into neuroestrogen regulation at the network level, and extend previous findings from human cortex by identifying a subset of aromatase neurons as putative inhibitory interneurons.

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Section: Introductionmentioning

confidence: 99%

Clustered organization and region‐specific identities of estrogen‐producing neurons in the forebrain of Zebra Finches (Taeniopygia guttata)

Ikeda

Krentzel

Oliver

et al. 2017

J of Comparative Neurology

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“…Peak neurogenesis in NCM occurs 40 days after the bird hatches, declining at 60 and 120 days respectively, though neurogenesis remains higher for longer if the critical period is artificially lengthened by isolating young birds (Asik, 2016). This means that, like in the HVC, NCM neurogenesis is associated with the critical period for song learning.…”

Section: The Caudomedial Nidopalliummentioning

confidence: 99%

A Comparison of Habituation Rates in Adult-Born and General Population Neurons in the Zebra Finch Caudomedial Nidopallium

Levinson¹

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Post-Hatch Neuron Incorporation in The Zebra Finch Caudomedial Nidopallium (NCM) in Relation to Vocal Learning

Cited by 2 publications

References 0 publications

Clustered organization and region‐specific identities of estrogen‐producing neurons in the forebrain of Zebra Finches (Taeniopygia guttata)

Clustered organization and region‐specific identities of estrogen‐producing neurons in the forebrain of Zebra Finches (Taeniopygia guttata)

A Comparison of Habituation Rates in Adult-Born and General Population Neurons in the Zebra Finch Caudomedial Nidopallium

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