Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome

Young, Michael D.; Cripps, Allan W.; Nimmo, Graeme R.; Driel, Mieke van

doi:10.1002/14651858.cd010586.pub2

Cited by 19 publications

(4 citation statements)

References 118 publications

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“…Another option to prevent congenital Zika virus infections in pregnant women would be the administration of human or humanized antibodies (74,119,122,123). Passive immunoglobulin therapies have been established previously for preventing birth defects caused by other viruses such as rubella virus, varicella-zoster virus, or cytomegaloviruses (162)(163)(164). The demonstration that some of the Zika virus E-specific antibodies have very strong neutralizing activities (Table 1) makes them attractive for passive immunotherapy.…”

Section: Antibodies and Passive Immunizationmentioning

confidence: 99%

The Antigenic Structure of Zika Virus and Its Relation to Other Flaviviruses: Implications for Infection and Immunoprophylaxis

Heinz

Stiasny

2017

Microbiol Mol Biol Rev

162

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Zika virus was discovered ∼70 years ago in Uganda and maintained a low profile as a human disease agent in Africa and Asia. Only recently has it caused explosive outbreaks in previously unaffected regions, first in Oceania and then in the Americas since 2015. Of special concern is the newly identified link between congenital malformations (especially microcephaly) and Zika virus infections during pregnancy. At present, it is unclear whether Zika virus changed its pathogenicity or whether the huge number of infections allowed the recognition of a previously cryptic pathogenic property. The purpose of this review is to discuss recent data on the molecular antigenic structure of Zika virus in the context of antibody-mediated neutralization and antibody-dependent enhancement (ADE) of infection, a phenomenon that has been implicated in the development of severe disease caused by the related dengue viruses. Emphasis is given to epitopes of antibodies that potently neutralize Zika virus and also to epitopes that provide antigenic links to other important human-pathogenic flaviviruses such as dengue, yellow fever, West Nile, Japanese encephalitis, and tick-borne encephalitis viruses. The antigenic cross talk between Zika and dengue viruses appears to be of special importance, since they cocirculate in many regions of endemicity and sequential infections are likely to occur frequently. New insights into the molecular antigenic structure of Zika virus and flaviviruses in general have provided the foundation for great progress made in developing Zika virus vaccines and antibodies for passive immunization.

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Section: Antibodies and Passive Immunizationmentioning

confidence: 99%

The Antigenic Structure of Zika Virus and Its Relation to Other Flaviviruses: Implications for Infection and Immunoprophylaxis

Heinz

Stiasny

2017

Microbiol Mol Biol Rev

162

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“…None of the guidelines examined cite a recent Cochrane review on the subject of the effectiveness of passive immunization for preventing rubella. 51 The review concludes that IG seems to be of benefit for preventing rubella up to 5 d after exposure, but notes the lack of evidence directly in relation to the prevention of congenital rubella syndrome.…”

Section: Intravenousmentioning

confidence: 99%

The indications and safety of polyvalent immunoglobulin for post-exposure prophylaxis of hepatitis A, rubella and measles

Young

2019

Human Vaccines & Immunotherapeutics

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Derived from pooled blood donations, polyvalent immunoglobulins are used for post-exposure prophylaxis as one aspect of the public health management of hepatitis A, rubella and measles. This review summarizes the safety profile of these blood products and the current recommendations for their use for the prevention of hepatitis A, rubella and measles among people who have been exposed to these diseases. The current recommendations are drawn from the most recent publicly available national guidelines of the United States,

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“…Für den Zeitraum in dem eine aktive PEP-Impfung nicht möglich ist, sollte nach einem relevanten Masernkontakt eine postexpositionelle passive Immunisierung mittels polyvalenter-IgG-Gabe möglichst innerhalb von 6 Tagen nach Exposition erfolgen (polyvalentes IgG 1 × 400 mg/kgKG i. v.; Off-Label-Gebrauch) [327,330]. Gegen Röteln kann eine postexpositionelle passive Impfung mit polyvalentem-IgG erwogen werden, da die Gabe innerhalb von 5 Tagen nach Exposition klinische Symptome abschwächen und die Ausscheidung des Virus sowie eine Virämie senken kann [301,387]. Eine postexpositionelle passive Impfung gegen Mumps wird aufgrund der fehlenden Effektivität nicht empfohlen [58,287].…”

Section: Postexpositionelle Impfungen Mit Lebendimpfstoffenunclassified

Impfen bei Immundefizienz

Laws

Baumann

Bogdan

et al. 2020

Bundesgesundheitsbl

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Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome

Abstract: Post-exposure passive immunisation for preventing rubella and congenital rubella syndrome.

Cited by 19 publications

References 118 publications

The Antigenic Structure of Zika Virus and Its Relation to Other Flaviviruses: Implications for Infection and Immunoprophylaxis

The Antigenic Structure of Zika Virus and Its Relation to Other Flaviviruses: Implications for Infection and Immunoprophylaxis

The indications and safety of polyvalent immunoglobulin for post-exposure prophylaxis of hepatitis A, rubella and measles

Impfen bei Immundefizienz

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