“…In mice, intraperitoneal injections of TETS or PTX cause similar sequences of immobility, myoclonic body jerks, clonic seizures of the forelimbs and/or hindlimbs, tonic seizures (falling on the side followed by forelimb tonic contraction and hindlimb tonic extension), and eventually death (Zolkowska et al, 2012). Systematic TETS exposures that are not fatal produce transient gliosis (2-3 days postexposure) in both the hippocampus and cortex without evidence of cellular injury and neurodegeneration (Zolkowska et al, 2012;Vito et al, 2014). In contrast, administration of KA to rats induces a distinct progression of symptoms including staring episodes, head bobbing, numerous wet dog shakes, and isolated limbic motor seizures that increase in frequency, eventually leading to status epilepticus (Scerrati et al, 1986), which resemble the clinic features of human temporal lobe epilepsy (Ben-Ari, 1985).…”