Post‐exercise hypotension: the effects of epanolol or atenolol on some hormonal and cardiovascular variables in hypertensive men.

Wilcox, R G; Bennett, T; Macdonald, I. A.; Pipkin, Broughton; Baylis, P. H.

doi:10.1111/j.1365-2125.1987.tb03156.x

Cited by 20 publications

(29 citation statements)

References 26 publications

(25 reference statements)

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“…[13][14][15] However, its occurrence in normotensive humans is inconsistent. Although we have found that PEH can be detected in normotensive individuals, 16 it was found to be much less consistent and of lesser magnitude than in hypertensive individuals.…”

Section: Does Peh Occur In All Individuals?mentioning

confidence: 99%

“…10,11,19,22,24,[31][32][33]35,41,[43][44][45][59][60][61]63,71,72 Treadmill exercise at similar intensities has also been documented to elicit PEH. 14,15,20,25,34,40,[55][56][57][58] Direct comparisons of the effect of exercise intensity have, for the most part, found that PEH occurs independent of exercise intensity. We have found no difference in the magnitude of hypotension following 30 min of cycle ergometry at power outputs eliciting 50% and 75% V · O 2 Peak in normotensive volunteers.…”

Section: Intensity Of the Exercisementioning

confidence: 99%

“…Measures of circulating adrenaline indicate that levels are elevated 60 or unchanged 14,39 during the hypotensive period. Our finding that PEH is largely independent of exercise intensity combined with the fact that it also persists during adrenaline infusion 60 and ␤-receptor blockade 14 suggests that any role of adrenaline in PEH is minimal.…”

Section: Noradrenaline and Adrenalinementioning

confidence: 99%

“…Although mildly hypertensive individuals may be able to control their condition with exercise alone, more severely inflicted individuals may need to remain on medication. An early study by Wilcox et al 14 documented the additive effect of exercise and ␤-adrenergic antagonist drugs on PEH. However, the constraints of ␤-adrenergic blockade on exercise capacity may make this an unsuitable combination.…”

Section: Future Directionsmentioning

confidence: 99%

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Potential causes, mechanisms, and implications of post exercise hypotension

2002

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Post exercise hypotension (PEH) is a phenomenon of a prolonged decrease in resting blood pressure in the minutes and hours following acute exercise. Knowledge of PEH is potentially useful in designing first line strategies against hypertension as well as allowing a further understanding of blood pressure regulation in both Keywords: blood pressure; vascular; cardiac; opioids; exercise Blood pressure responses during exerciseDuring dynamic exercise, cardiac output increases dramatically to ensure adequate perfusion to the working musculature. This increase is achieved by a withdrawal of parasympathetic tone (causing an increased heart rate and contractility), an increase in sympathetic activity (directly and indirectly increasing heart rate and contractility) and pronounced vasoconstriction of the venous vasculature (causing a greater venous return and therefore stroke volume). In parallel, the need for increased blood flow and oxygen delivery to the exercising muscle is achieved through regional vasodilation of those arterioles supplying blood to the exercising tissue in combination with a vasoconstriction of arterioles, which perfuse non-essential tissues. Although the mechanism of vasodilation at the onset of exercise is not fully understood, many compounds (eg, potassium, adenosine, nitric oxide, etc) have been implicated in the exercise induced changes. Contraction of the active muscle mass also assists in returning blood towards the heart. This 'muscle pump' effect further increases venous return and stroke volume.Increased cardiac output and vasoconstriction in non-exercising vascular beds increases systolic blood pressure (SBP), but the significant vasodilation at the exercising muscle beds helps to buffer this increase and results in a minimal rise in diastolic blood pressure (DBP). As exercise continues Correspondence: JR MacDonald, McMaster University Medical Centre, Room 4U18, 1200 Main Street West, Hamilton, Ontario L8N 3Z5, Canada. E-mail: jaymacȰmcmaster.ca health and disease. Following a brief review of blood pressure responses to exercise, this paper will provide a current and comprehensive summary of PEH and integrate the current state of knowledge surrounding it.

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Section: Does Peh Occur In All Individuals?mentioning

confidence: 99%

Section: Intensity Of the Exercisementioning

confidence: 99%

Section: Noradrenaline and Adrenalinementioning

confidence: 99%

Section: Future Directionsmentioning

confidence: 99%

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Potential causes, mechanisms, and implications of post exercise hypotension

2002

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“…Studies examining both peripherally [1][2][3] and centrally [4][5][6][7] mediated mechanisms have produced inconsistent results.…”

Section: Introductionmentioning

confidence: 99%

The effects of exercising muscle mass on post exercise hypotension

MacDonald

MacDougall

2000

J Hum Hypertens

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Nine recreationally active, borderline hypertensive subjects completed 30 min of arm ergometry (ARM) at 65% V O 2 peak and 30 min of leg ergometry (LEG) at 70% V O 2 Peak (randomised order). Blood pressure was monitored before and for 1 h after exercise using the Finapres method. Systolic, diastolic and mean blood pressures were significantly reduced for the entire 1 h post exercise. This reduction was independent of exercise modality, but there was an indication for the duration of

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Pharmacokinetic and pharmacodynamic studies in man with an antianginal agent ‘Visacor’

Cockshott¹,

McAinsh²,

Norris³

1990

Biopharm & Drug Disp

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This randomized, double-blind, crossover study in 10 healthy male volunteers compared four single oral doses of ICI 141,292 ('Visacor'), i.e. 50, 100, 200, and 300 mg, with placebo. Venous blood samples were collected pre-dose and at various times after dosing and the concentrations of ICI 141,292 in the plasma were determined by radioimmunoassay. A standardized 4-min bicycle exercise test was also performed and before this the resting haemodynamic parameters were assessed. Peak plasma concentrations of ICI 141,292 and the area under the plasma concentration-time curve increased disproportionately with dose such that after scaling to a dose of 200 mg there remained a significant linear trend with dose. The time to peak plasma concentration displayed an increasing trend with dose and, once again, the linear component of this trend was statistically significant. The mean heart rates during exercise were all significantly reduced compared to placebo for 24 h by each of the doses (range 7.8 to 17.4 beats min-1 at 24 h, p less than 0.01). The increase in heart rate during exercise was inversely related to the logarithm of the ICI 141,292 plasma concentration with higher plasma concentrations being associated with lower heart rate increases. The mean supine resting heart rates were slightly but significantly reduced at 2 and 6 h after dosing by each treatment and by the 300 mg dose at 24 h. Each of the doses of ICI 141,292 was well tolerated.

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Post‐exercise hypotension: the effects of epanolol or atenolol on some hormonal and cardiovascular variables in hypertensive men.

Cited by 20 publications

References 26 publications

Potential causes, mechanisms, and implications of post exercise hypotension

Potential causes, mechanisms, and implications of post exercise hypotension

The effects of exercising muscle mass on post exercise hypotension

Pharmacokinetic and pharmacodynamic studies in man with an antianginal agent ‘Visacor’

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