Post-Diagnosis use of Antioxidant Vitamin Supplements and Breast Cancer Prognosis: A Systematic Review and Meta-Analysis

Li, Yong; Lin, Qimou; Lu, Xiaoju; Li, Weiwen

doi:10.1016/j.clbc.2021.09.001

Cited by 8 publications

(4 citation statements)

References 26 publications

(63 reference statements)

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“…Despite varying vitamin C statuses in patients with breast cancer based on their cancer stage, a meta-analysis of 17.000 patients indicates that the post-diagnosis utilization of antioxidant vitamin supplements, including vitamin C, does not exhibit a significant association with the overall mortality [82]. However, the intake of vitamin C supplements after diagnosis shows a statistically significant correlation with a reduced risk of total mortality.…”

Section: Vitamin Cmentioning

confidence: 99%

Micronutrient Status and Breast Cancer: A Narrative Review

Forma,

Grunwald,

Zembala

et al. 2024

IJMS

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Breast cancer is one of the most common cancers worldwide, at the same time being one of the most prevalent causes of women’s death. Many factors such as alcohol, weight fluctuations, or hormonal replacement therapy can potentially contribute to breast cancer development and progression. Another important factor in breast cancer onset includes micronutrient status. In this narrative review, we analyzed 23 micronutrients and their possible influence on breast cancer onset and progression. Further, the aim of this study was to investigate the impact of micronutrient status on the prevention of breast cancer and its possible influence on various therapeutic pathways. We researched meta-analyses, systemic and narrative reviews, retrospective studies, as well as original studies on human and animal models. The results of these studies indicate a possible correlation between the different levels of micronutrients and a decreased risk of breast cancer as well as a better survival rate. However, further studies are necessary to establish adequate doses of supplementation of the chosen micronutrients and the exact mechanisms of micronutrient impact on breast cancer therapy.

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Section: Vitamin Cmentioning

confidence: 99%

Micronutrient Status and Breast Cancer: A Narrative Review

Forma,

Grunwald,

Zembala

et al. 2024

IJMS

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“…However, there is no consensus on the association between dietary antioxidant intake and cancer prognosis. The findings of a systematic review and meta-analysis [ 10 ] indicated that the oral antioxidants during treatment was not related to the survival rate of breast cancer. The author speculated that with chemotherapy and radiation therapy producing reactive oxygen species (ROS) as one of their anti-tumor mechanisms, excessive dietary antioxidants may neutralize ROS [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model

et al. 2023

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Objective: Dietary antioxidants are associated with risk of death in cancer patients, and they were used to evaluate the prognosis of cancer patients. Dietary antioxidant index (DAI) can be used to evaluate dietary antioxidant content comprehensively; this study aimed to investigate the effect of preoperative DAI on health-related quality of life in patients with esophageal cell squamous carcinoma (ESCC). Methods: Data on dietary intakes were collected using a validated food-frequency questionnaire (FFQ). DAI was calculated for all study participants based on FFQ data of each participant. The study involved conducting several follow-up activities with patients diagnosed with ESCC to evaluate their quality of life. The approach employed in the study was to conduct a telephone interview. The EORTC Quality of Life Questionnaire-Core Questionnaire (EORTC QLQ-C30, version 3.0) and the Esophageal Cancer Module (EORTC QLQ-OES18) were used to collect data on the quality of life of the patients; all patients completed the full follow-up. Results: This prospective study was performed on 376 participants who were recruited from Fujian Cancer Hospital and First Hospital of Fujian Medical University. They all were diagnosed with ESCC. The results indicated that the time to deterioration of global health status (p = 0.043), cognitive functioning (p = 0.031), dry mouth (p = 0.019), and speech problems (p = 0.031) significantly delay in the high DAI group. Univariate and multivariate Cox regression analysis showed that global health status (HR = 0.718, 95% CI: 0.532–0.969), cognitive functioning (HR = 0.641, 95% CI: 0.450–0.913), dry mouth (HR = 0.637, 95% CI: 0.445–0.911), and speech problems (HR = 0.651, 95% CI: 0.449–0.945) were improved in the high DAI group. Conclusions: Prognostic value of preoperative DAI was significant for patients with ESCC who undergo surgical intervention. Its level was positively correlated with the postoperative quality of life of patients, which can delay and improve the occurrence of postoperative physical function and symptom deterioration.

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“…For example, it was previously reported that N -acetyl cysteine (NAC) inhibited cell growth in cancer [ 8 , 13 , 14 ]. However, a recently published meta-analysis did not confirm the efficacy of antioxidants, including NAC, for cancer treatment [ 15 , 16 , 17 ]. This is because small-molecule drugs diffuse into the entire body immediately after administration and are rapidly metabolized.…”

Section: Introductionmentioning

confidence: 99%

Newly Designed Cysteine-Based Self-Assembling Prodrugs for Sepsis Treatment

Koda

Nagasaki

2023

Pharmaceutics

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Reactive oxygen species (ROS) are essential signaling molecules that maintain intracellular redox balance; however, the overproduction of ROS often causes dysfunction in redox homeostasis and induces serious diseases. Antioxidants are crucial candidates for reducing overproduced ROS; however, most antioxidants are less effective than anticipated. Therefore, we designed new polymer-based antioxidants based on the natural amino acid, cysteine (Cys). Amphiphilic block copolymers, composed of a hydrophilic poly(ethylene glycol) (PEG) segment and a hydrophobic poly(cysteine) (PCys) segment, were synthesized. In the PCys segment, the free thiol groups in the side chain were protected by thioester moiety. The obtained block copolymers formed self-assembling nanoparticles (NanoCys(Bu)) in water, and the hydrodynamic diameter was 40–160 nm, as determined by dynamic light scattering (DLS) measurements. NanoCys(Bu) was stable from pH 2 to 8 under aqueous conditions, as confirmed by the hydrodynamic diameter of NanoCys(Bu). Finally, NanoCys(Bu) was applied to sepsis treatment to investigate the potential of NanoCys(Bu). NanoCys(Bu) was supplied to BALB/cA mice by free drinking for two days, and lipopolysaccharide (LPS) was intraperitoneally injected into the mice to prepare a sepsis shock model (LPS = 5 mg per kg body weight (BW)). Compared with the Cys and no-treatment groups, NanoCys(Bu) prolonged the half-life by five to six hours. NanoCys(Bu), designed in this study, shows promise as a candidate for enhancing antioxidative efficacy and mitigating the adverse effect of cysteine.

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Post-Diagnosis use of Antioxidant Vitamin Supplements and Breast Cancer Prognosis: A Systematic Review and Meta-Analysis

Cited by 8 publications

References 26 publications

Micronutrient Status and Breast Cancer: A Narrative Review

Micronutrient Status and Breast Cancer: A Narrative Review

Association between the Preoperative Dietary Antioxidant Index and Postoperative Quality of Life in Patients with Esophageal Squamous Cell Carcinoma: A Prospective Study Based on the TTD Model

Newly Designed Cysteine-Based Self-Assembling Prodrugs for Sepsis Treatment

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