Post-COVID-vaccine autoimmune/inflammatory syndrome in response to adjuvants (ASIA syndrome) manifesting as subacute thyroiditis

Das, Liza; Bhadada, Sanjay Kumar; Sood, Apurva

doi:10.1007/s40618-021-01681-7

Cited by 52 publications

(39 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…According to the above-mentioned search strategy, 35 articles were initially found. Among these, 5 were excluded and a total of 30 articles reporting data on 48 patients were included in the systematic review [ 17 , 23 – 51 ]. Study flow-chart is depicted in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…So far, some possible pathophysiological explanations for post-vaccination SAT have been proposed, yet distinct mechanisms remain unclear. The first mechanism suggested is the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) [ 17 ], an adjuvants-triggered immune reaction due to vaccine (or other drugs or products) excipients which could determine dysregulation of both innate and adaptive immune systems, possibly causing destructive thyroiditis or even new onset of autoimmune diseases such as Hashimoto’s thyroiditis [ 18 ]. SAT as part of ASIA syndrome has been formerly described also for hepatitis B, Human Papillomavirus, and influenza vaccinations [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

SARS-CoV-2 vaccine-associated subacute thyroiditis: insights from a systematic review

Ippolito¹,

Gallo²,

Rossini

et al. 2022

J Endocrinol Invest

View full text Add to dashboard Cite

Purpose To perform a systematic review on published cases of subacute thyroiditis (SAT) secondary to SARS-CoV-2 vaccination, to highlight main features and increase the awareness of this condition. Methods Original reports of SAT developed after SARS-CoV-2 vaccination (mRNA, viral vector, or inactivated virus vaccines) were retrieved from a search of electronic databases. Individual patient data on demographics, medical history, type of vaccine, workup and therapies were collected. Wilcoxon rank-sum, Kruskal–Wallis and chi-squared tests were employed for comparisons. Results 30 articles including 48 reports were retrieved, 3 additional cases evaluated by the Authors were described and included for analysis. Of the 51 patients, 38 (74.5%) were women, median age was 39.5 years (IQR 34–47). Patients developed SAT after a median of 10 days (IQR 4–14) after the vaccine shot. Baseline thyroid exams revealed thyrotoxicosis in 88.2% of patients, decreasing at 31.6% at follow-up. Corticosteroids were used in 56.4% of treated patients. Patients undergoing non-mRNA vaccines were most frequently Asian (p = 0.019) and reported more frequently weight loss (p = 0.021). All patients with a previous diagnosis of thyroid disease belonged to the mRNA vaccine group. Conclusion SARS-CoV-2 vaccine-associated SAT is a novel entity that should be acknowledged by physicians. Previous history of thyroid disease may predispose to develop SAT after mRNA vaccines, but further studies and larger cohorts are needed to verify this suggestion. SARS-CoV-2 vaccine-associated SAT is usually of mild/moderate severity and could be easily treated in most cases, thus it should not raise any concern regarding the need to be vaccinated.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

SARS-CoV-2 vaccine-associated subacute thyroiditis: insights from a systematic review

Ippolito¹,

Gallo²,

Rossini

et al. 2022

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…Spontaneous reports of suspected adverse reactions are an important source of information for pharmacovigilance activities, as they allow to detect potential safety signals associated with the use of medicines to make them safer, to the benefit of all patients. There are several reports in Literature of people developing thyroid disorders, in particular subacute thyroiditis, after receiving a COVID-19 vaccine [6][7][8]. In the past, the possibility of developing thyroiditis has been reported as a possible rare complication of Influenza, HPV and HBV vaccination.…”

Section: Discussionmentioning

confidence: 99%

Silent thyroiditis following vaccination against COVID-19: report of two cases

Capezzone

Tosti-Balducci

Morabito

et al. 2022

J Endocrinol Invest

View full text Add to dashboard Cite

Purpose It is well established that thyroiditis and other thyroid disorders can be induced by COVID-19 infection, but there is limited information about the autoimmune/inflammatory syndrome induced by adjuvants (ASIA) after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination. We report two cases of thyrotoxicosis following SARS-CoV-2 vaccine. Methods and results Two young health care peoples (wife and husband) received a first dose of SARS-CoV-2 vaccine, and few weeks later developed clinical manifestations of thyroid hyperactivity, with increased thyroid hormone levels on thyroid function tests, suppressed thyroid-stimulating hormone and negative antithyroid antibodies, despite being healthy before vaccination. They were diagnosed at the 4th week after first dose of SARS-Cov-2 vaccine as silent thyroiditis and followed without treatment, since their symptoms were not severe. At the 6th week, the patients became wholly asymptomatic and their thyroid function returned to normal. Conclusions Thyrotoxicosis can occur after SARS-CoV-2 vaccination probably related to silent thyroiditis.

show abstract

“…Recently, following the massive vaccination programme worldwide, there have been a few reports of thyroid dysfunction after SARS-CoV-2 vaccination, including SAT [ [13] , [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] ] and Graves' disease [ 19 , [29] , [30] , [31] ]. All types of vaccines have been involved, namely inactivated virus SARS-CoV-2 vaccines CORONAVAC [ [13] , [14] , [15] ] and COVAXIN [ 21 ], viral vector-based vaccines VAXZEVRIA [ [16] , [17] , [18] , [19] , [20] , 31 ] and Janssen [ 19 ] and mRNA-based vaccines COMIRNATY [ [22] , [23] , [24] , [25] , [26] , [27] , [28] ] and MODERNA [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, SAT has been described following influenza or hepatitis B vaccination [ [7] , [8] , [9] , [10] , [11] , [12] ]. Recently, cases have been reported of SAT following SARS-CoV-2 vaccination with CoronaVac (Sinovac Life Sciences, China) [ [13] , [14] , [15] ], Vaxzevria (AstraZeneca, Sweden) [ [16] , [17] , [18] , [19] , [20] ], Spikevax (Moderna Biotech, Spain) [ 20 ], Covaxin (Bharat Biotech, India) [ 21 ], and Pfizer-BioNTech SARS-CoV-2 mRNA vaccine (BioNTech, Fosun Pharma, Pfizer, Germany and USA) [ [22] , [23] , [24] , [25] , [26] , [27] , [28] ].…”

Section: Introductionmentioning

confidence: 99%

Recurring subacute thyroiditis after SARS-CoV-2 mRNA vaccine: A case report

Vasileiou

Paschou

Tzamali

et al. 2022

Case Reports in Women's Health

View full text Add to dashboard Cite

SARS-CoV-2 vaccination is the most powerful and promising tool against the COVID-19 pandemic. Millions of people have been vaccinated worldwide. Recently, few cases of subacute thyroiditis following SARS-CoV-2 vaccination with various types of vaccine have been reported of subacute thyroiditis following SARS-CoV-2 vaccination with various types of vaccine. We describe here a 36-year-old woman who presented with subacute thyroiditis 10 days after she had received her first dose of the SARS-CoV-2 mRNA vaccine Comirnaty (Pfizer/BioNTech); the condition receded but then recurred 10 days after she received her second dose. As vaccination programmes proceed, clinicians' attention and vigilance for such cases will be increased. Physicians need to know that subacute thyroiditis is a mild and self-limiting condition in the majority of cases. Last but not least, the benefits of vaccination against COVID-19 outweigh the side-effects reported so far.

show abstract

Post-COVID-vaccine autoimmune/inflammatory syndrome in response to adjuvants (ASIA syndrome) manifesting as subacute thyroiditis

Cited by 52 publications

References 9 publications

SARS-CoV-2 vaccine-associated subacute thyroiditis: insights from a systematic review

SARS-CoV-2 vaccine-associated subacute thyroiditis: insights from a systematic review

Silent thyroiditis following vaccination against COVID-19: report of two cases

Recurring subacute thyroiditis after SARS-CoV-2 mRNA vaccine: A case report

Contact Info

Product

Resources

About