Post-COVID Syndrome and Severity of COVID-19: A Cross-Sectional Epidemiological Evaluation From North India

Uniyal, Nidhi; Sethi, Yashendra; Sharma, Pradeep C; Sayana, Ashutosh; Jeet, Narayan; Agarwal, Alekh; Rawat, Vijay

doi:10.7759/cureus.27345

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Fatigue was the most common symptom reported in post-COVID syndrome assessment, followed by post-exertion malaise and headache. Similar findings have been reported by Uniyal N et al and Anjana NK et al 16,17 A total of 29 participants reported fatigue and 5 post-COVID syndrome cases reported difficulty in breathing. A total of 8 participants in the post-COVID syndrome assessment reported difficulty in concentrating or thinking and mood changes.…”

Section: Discussionsupporting

confidence: 88%

Incidence of breakthrough infection after COVID vaccination and effect of post-covid-19 syndrome on medical students in a tertiary care hospital in Telangana

Khan,

Bompalli,

et al. 2024

IJMMTD

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Even though many breakthrough infections have been reported in the Telangana region, adequate data regarding them are not available. In addition, there is evidence that SARS-CoV-2 infection can result in long-term physical and mental health consequences. To estimate the incidence of breakthrough infections after COVID-19 vaccination and the effect of Post COVID 19 syndrome on staff and medical students in a tertiary care hospital in Telangana.1. To detect the incidence of breakthrough infections in staff and students in our institute; 2. To measure the effect of post-COVID-19 syndrome on the staff, undergraduate, and postgraduate medical students in our institute This study was carried out in a tertiary care medical college located near Hyderabad. This was a cross-sectional retrospective and prospective study where data was collected from individuals who were PCR-confirmed COVID-19-infected individuals diagnosed from December 2021 to July 2022. The cases were classified according to AIIMS clinical guidance for the management of adult COVID-19 patients. To assess the post-COVID syndrome in the staff and medical students, complaints of breathlessness, fatigue, difficulty in concentrating, and mood changes were further evaluated by using the modified dyspnea Medical Research Council scale, Fatigue Assessment scale (FAS), and Depression, Anxiety, Stress scale -21(DASS-21) respectively. Statistical analysis was performed using SPSS software version 23. The incidence of breakthrough infections was found to be 9.40%. The maximum number was observed in second-year medical undergraduates followed by medical post-graduates. A total of 40 participants (21.16%) reported suffering from post-COVID-19 syndrome. Fatigue was the most common symptom reported, followed by post-exertion malaise and headache. The incidence of breakthrough infections shows that increased awareness and prompt management of post –COVID syndrome is crucial in the post pandemic era.

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Section: Discussionsupporting

confidence: 88%

Incidence of breakthrough infection after COVID vaccination and effect of post-covid-19 syndrome on medical students in a tertiary care hospital in Telangana

Khan,

Bompalli,

et al. 2024

IJMMTD

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“…Via multivariate analysis, normal weight according to BMI was found as an independent protective factor for post-COVID-19 fatigue, and this is consistent with previous literature data. High BMIs and obesity are recognized risk factors for the development of post-COVID-19 symptoms [38,47,48]. A possible explanation for this association may lie in the high levels of inflammation present in obese patients [49], which also constitutes a pathophysiological basis with which to explain the higher risk of mortality for obese patients during the acute stage of infection [50].…”

Section: Discussionmentioning

confidence: 99%

Physical Impact of SARS-CoV-2 Infection in a Population of Italian Healthcare Workers

Lulli

Baldassarre

Chiarelli

et al. 2023

IJERPH

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SARS-CoV-2 infection often causes symptoms and illness that can last for months after the acute phase, i.e., so-called “Long COVID” or Post-acute COVID-19. Due to the high prevalence of SARS-CoV-2 infection among Healthcare Workers (HCWs), post-COVID-19 symptoms can be common and threaten workers’ occupational health and healthcare systems’ functioning. The aim of this cross-sectional, observational study was to present data related to post-COVID-19 outcomes in a population of HCWs infected by COVID-19 from October 2020 to April 2021, and to identify possible factors associated with the persistence of illness, such as gender, age, previous medical conditions, and features of acute illness. A total of 318 HCWs who had become infected by COVID-19 were examined and interviewed approximately two months after their recovery from the infection. The clinical examinations were performed by Occupational Physicians in accordance with a specific protocol at the Occupational Medicine Unit of a tertiary hospital in Italy. The mean age of the participants was 45 years old, and 66.7% of the workers were women while 33.3% were men; the sample mainly consisted of nurses (44.7%). During the medical examination, more than half of the workers mentioned that they had experienced multiple residual bouts of illness after the acute phase of infection. Men and women were similarly affected. The most reported symptom was fatigue (32.1%), followed by musculoskeletal pain (13.6%) and dyspnea (13.2%). In the multivariate analysis, dyspnea (p < 0.001) and fatigue (p < 0.001) during the acute stage of illness and the presence of any limitation in working activities, in the context of fitness for a work evaluation performed while the occupational medicine surveillance program was being conducted (p = 0.025), were independently associated with any post-COVID-19 symptoms, which were considered final outcomes. The main post-COVID-19 symptoms—dyspnea, fatigue, and musculoskeletal pain—showed significant associations with dyspnea, fatigue, and musculoskeletal pain experienced during the acute stage of infection, with the presence of limitations in working activities, and pre-existing pneumological diseases. A normal weight according to body mass index was a protective factor. The identification of vulnerable workers as those with limitations in working activities, pneumological diseases, a high BMI, and of an older age and the implementation of preventive measures are key factors for preserving Occupational Health. Fitness-to-work evaluations performed by Occupational Physicians can be considered a complex index of overall health and functionality that can identify workers who may suffer from relevant post-COVID-19 symptoms.

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“…The largest was a population-based study involving 456,002 individuals from the United Kingdom at least 4 weeks after COVID-19, where arthralgia was present in 2% to 3% of the patients [72]. In 10 other studies, including 9756 patients overall, a prevalence of joint pain ranging from 10% to 19% was described [35,38,40,41,45,46,51,58,69,73], while 11 studies assessing post-COVID-19 symptoms in 28,303 patients showed higher figures, between 20% and 29% [28,34,42,43,47,49,64,66,71,75,76]. Most of these patients were contributed by Wang et al [71].…”

Section: Joint Pain In Post-covid-19 Patientsmentioning

confidence: 99%

Post-Acute COVID-19 Joint Pain and New Onset of Rheumatic Musculoskeletal Diseases: A Systematic Review

et al. 2023

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As the number of reports of post-acute COVID-19 musculoskeletal manifestations is rapidly rising, it is important to summarize the current available literature in order to shed light on this new and not fully understood phenomenon. Therefore, we conducted a systematic review to provide an updated picture of post-acute COVID-19 musculoskeletal manifestations of potential rheumatological interest, with a particular focus on joint pain, new onset of rheumatic musculoskeletal diseases and presence of autoantibodies related to inflammatory arthritis such as rheumatoid factor and anti-citrullinated protein antibodies. We included 54 original papers in our systematic review. The prevalence of arthralgia was found to range from 2% to 65% within a time frame varying from 4 weeks to 12 months after acute SARS-CoV-2 infection. Inflammatory arthritis was also reported with various clinical phenotypes such as symmetrical polyarthritis with RA-like pattern similar to other prototypical viral arthritis, polymyalgia-like symptoms, or acute monoarthritis and oligoarthritis of large joints resembling reactive arthritis. Moreover, high figures of post-COVID-19 patients fulfilling the classification criteria for fibromyalgia were found, ranging from 31% to 40%. Finally, the available literature about prevalence of rheumatoid factor and anti-citrullinated protein antibodies was largely inconsistent. In conclusion, manifestations of rheumatological interest such as joint pain, new-onset inflammatory arthritis and fibromyalgia are frequently reported after COVID-19, highlighting the potential role of SARS-CoV-2 as a trigger for the development of autoimmune conditions and rheumatic musculoskeletal diseases.

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Post-COVID Syndrome and Severity of COVID-19: A Cross-Sectional Epidemiological Evaluation From North India

Cited by 5 publications

References 28 publications

Incidence of breakthrough infection after COVID vaccination and effect of post-covid-19 syndrome on medical students in a tertiary care hospital in Telangana

Incidence of breakthrough infection after COVID vaccination and effect of post-covid-19 syndrome on medical students in a tertiary care hospital in Telangana

Physical Impact of SARS-CoV-2 Infection in a Population of Italian Healthcare Workers

Post-Acute COVID-19 Joint Pain and New Onset of Rheumatic Musculoskeletal Diseases: A Systematic Review

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