Post-COVID syndrome: A prospective study in a tertiary hospital of Nepal

Shah, Sangam; Bhattarai, Shreeyash Raj; Basnet, Kriti; Adhikari, Yagya Raj; Adhikari, Tara Ballav; Bhatta, Nikita; Chamlagain, Rajan; Aryal, Suraj; Sah, Sanjit; Bhandari, Govinda; Bhandari, Bibek; Poudel, Sujan; Pant, Pankaj; Das, Santa Kumar

doi:10.1371/journal.pone.0272636

Cited by 7 publications

(10 citation statements)

References 42 publications

(55 reference statements)

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“…Post‐COVID syndrome includes symptoms like fever, sore throat, fatigue, and neurological and neuropsychiatric symptoms. 2 , 3 Some authors have also put forward a question of these symptoms occurring as a result of post‐traumatic distress and having a neuropsychiatric predominance. 8 Our patient also developed sleep disturbances and anxiety and the absence of abnormalities in other examinations and laboratory workups have supported this question.…”

Section: Discussionmentioning

confidence: 99%

“…Post‐COVID syndrome includes symptoms like fever, sore throat, fatigue, and neurological and neuropsychiatric symptoms 2,3 . Some authors have also put forward a question of these symptoms occurring as a result of post‐traumatic distress and having a neuropsychiatric predominance 8 .…”

Section: Discussionmentioning

confidence: 99%

“…These symptoms persist even after viral clearance and have no other explanation. 2 This was dismissed by scientific and medical communities at first, but later this got established as post‐COVID syndrome or long COVID. 3 , 4 The most common symptoms of the syndrome include fatigue and dyspnoea, while, symptoms of neuropsychiatric disorders, neurological disorders, insomnia, autonomic dysfunction, smell and taste dysfunctions, cough, hair loss, myalgia, wheezing, and cardiac and gastrointestinal issues are also reported in lesser frequencies.…”

Section: Introductionmentioning

confidence: 99%

“…Among those who recovered and survived the wave of COVID‐19, irrespective of the severity of the disease, were seen to develop new symptoms after the recovery. These symptoms persist even after viral clearance and have no other explanation 2 . This was dismissed by scientific and medical communities at first, but later this got established as post‐COVID syndrome or long COVID 3,4 .…”

Section: Introductionmentioning

confidence: 99%

“…3,4 The most common symptoms of the syndrome include fatigue and dyspnoea, while, symptoms of neuropsychiatric disorders, neurological disorders, insomnia, autonomic dysfunction, smell and taste dysfunctions, cough, hair loss, myalgia, wheezing, and cardiac and gastrointestinal issues are also reported in lesser frequencies. 2,3 In this case report, we present such a case of post-COVID syndrome in which the patient developed shortness of breath, fatigue, myalgia, and tingling sensation in hands and feet after recovery and these persisted after viral clearance. This case report is in line with CARE guidelines.…”

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confidence: 99%

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Post‐Coronavirus disease syndrome (post‐COVID‐19) syndrome: A case report

Thapa¹,

Pant

Singh³

et al. 2022

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Post‐Coronavirus disease syndrome (post‐COVID‐19) syndrome: A case report

Thapa¹,

Pant

Singh³

et al. 2022

Clinical Case Reports

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Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study

Shah,

Paudel,

Bhattarai

et al. 2023

Health Science Reports

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Background and AimsThe effectiveness of coronavirus disease 2019 (COVID‐19) vaccines in reducing symptoms, disease advancement, complications, and mortality in severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection has been well‐established. This case‐control study aimed to compare different blood parameters, and prognostic and survival outcomes of COVID‐19 patients based on vaccination status.MethodsWe performed a case‐control study that included hospitalized patients with COVID‐19 at Tribhuvan University Teaching Hospital, Kathmandu, Nepal. Individuals who received vaccination were designated as cases and unvaccinated individuals as controls. Demographics, co‐morbidity, clinical data, laboratory data, and disease outcomes were recorded for both groups. Multivariate, Cox, and linear regression were used for analysing blood parameters, hospital admission, survival, and hospital stay, respectively, between cases and controls.ResultsOut of 100 participants enrolled, 46 were vaccinated, and 54 weren't. At admission, ferritin and erythrocyte sedimentation rate (ESR) were significantly lower in cases. At discharge, cases showed a higher monocyte than controls. Ferritin, ESR, and d‐imer showed excellent performance in determining the severity of symptoms. Significant correlation and regression of ferritin and ESR with the length of hospital stay was observed. Length of hospital stay was significantly lower in cases than in controls. No significant differences between cases and controls were observed in mortality.ConclusionCOVID‐19 vaccines effectively reduced hospitalization duration. Ferritin and ESR were significantly lower in vaccinated individuals and showed the best utility in monitoring the disease.

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Prevalence and clinical presentations of post-COVID-19 conditions in Nepal

Basnet,

Thapa,

Bastola

et al. 2024

Preprint

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Introduction: The COVID-19 pandemic affected millions worldwide. While the major focus was on diagnosis and treatment of the acute phase of the disease, many individuals experienced long-term health even after recovery. These post-COVID-19 conditions encompass a broad range of physical, psychological, and cognitive symptoms that persist beyond the acute phase of the illness. The aim of this study was to find the prevalence and reported presentations of post-COVID-19 conditions in Nepal. Method: This is a retrospective cross-sectional study using structured questionnaire to collect hospital-based data available in the record of Curative Service Division, Department of Health Services of Nepal from October 2021 to September 2022. A total of 6151 cases were recorded in the study. Descriptive analysis was done for demographic and symptoms variable. Association of variables to post-COVID-19 condition are shown using univariate and multivariate logistic regression. Results: Among 6151 respondents (62.25% males), more than half (59.03%) had at least one symptom after recovery from acute COVID-19. The most common symptoms were anxiety (28.5%), loss of appetite (25.3%), shortness of breath (24.13%), fatigue (23.24%), depressed mood (18.79%), muscle ache (17.59%), chest pain (16.81%), headache (14.78%), and palpitation (13%). Multivariate analysis showed increased odds of post-COVID-19 conditions in smokers (adjusted OR [aOR] 1.53), those with chronic lung disease (aOR 1.71), neurological disorder (aOR 2.43) and those with use of supplementary oxygen during acute illness of COVID-19 (aOR 3.37). Conclusion: The prevalence of post-COVID-19 symptoms among the study population is found to be high. The main symptoms from our study and similar studies are anxiety, fatigue, loss of appetite, shortness of breath, muscle pain, headaches. Patients with smoking, hypoxia during acute illness and presence of chronic lung disease and neurological disorder had higher odds of getting post-COVID-19 conditions. Citing the findings, health system should focus upon the management and recording of such conditions for further evidence.

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Post-COVID syndrome: A prospective study in a tertiary hospital of Nepal

Cited by 7 publications

References 42 publications

Post‐Coronavirus disease syndrome (post‐COVID‐19) syndrome: A case report

Post‐Coronavirus disease syndrome (post‐COVID‐19) syndrome: A case report

Association of vaccination status with the clinicobiochemical profile, hospital stay, and mortality in COVID‐19: A case–control study

Prevalence and clinical presentations of post-COVID-19 conditions in Nepal

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