Post COVID-19 condition imposes significant burden in patients with advanced chronic kidney disease: A nested case-control study

Bouwmans, Pim; Malahe, S.Reshwan K.; Messchendorp, A. Lianne; Vart, Priya; Imhof, Céline; Sanders, Jan-Stephan F.; Gansevoort, Ron T.; de Vries, Aiko P.J.; Abrahams, Alferso C.; Bemelman, Frederike J.; Vervoort, Johanna P.M.; Hilbrands, Luuk B.; ten Dam, Marc A.G.J.; van den Dorpel, René M.A.; Rispens, Theo; Steenhuis, Maurice; Reinders, Marlies E.J.; Hemmelder, Marc H.

doi:10.1016/j.ijid.2024.106990

Cited by 7 publications

(4 citation statements)

References 32 publications

(46 reference statements)

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“…Higher incidences of diabetes [ 70 , 71 , 72 ], hypertension [ 73 ], and kidney disorders [ 74 , 75 ], among others, have been reported in individuals post-COVID-19 compared to non-COVID matched controls. Worsening of disease progression of existing clinical disorders has been reported in patients with hypertension [ 76 , 77 ], kidney disease [ 78 ], multiple sclerosis [ 79 , 80 , 81 , 82 , 83 , 84 ], dementia [ 85 , 86 , 87 ], and other neurological conditions [ 86 , 87 , 88 , 89 , 90 , 91 ] post-COVID-19 compared to non-COVID matched controls. We expect that there will be accelerated aging of multiorgan systems in some individuals, especially those with experience of severe acute COVID-19 and/or with major pre-existing comorbidities.…”

Section: Resultsmentioning

confidence: 99%

A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

Song,

Cui

et al. 2024

Diagnostics

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Background: Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, and underlying mechanisms to guide global responses; Methods: We conducted a literature review, analyzing peer-reviewed articles and reports to gather comprehensive data on long COVID’s epidemiology, symptomatology, and management approaches; Results: Our analysis revealed a wide array of long COVID symptoms and risk factors, with notable demographic variability. The current understanding of its pathophysiology suggests a multifactorial origin yet remains partially understood. Emerging diagnostic criteria and potential therapeutic strategies were identified, highlighting advancements in long COVID management; Conclusions: This review highlights the multifaceted nature of long COVID, revealing a broad spectrum of symptoms, diverse risk factors, and the complex interplay of physiological mechanisms underpinning the condition. Long COVID symptoms and disorders will continue to weigh on healthcare systems in years to come. Addressing long COVID requires a holistic management strategy that integrates clinical care, social support, and policy initiatives. The findings underscore the need for increased international cooperation in research and health planning to address the complex challenges of long COVID. There is a call for continued refinement of diagnostic and treatment modalities, emphasizing a multidisciplinary approach to manage the ongoing and evolving impacts of the condition.

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Section: Resultsmentioning

confidence: 99%

A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

Song,

Cui

et al. 2024

Diagnostics

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“…In addition to acute COVID-19 in which respiratory symptoms are more prominent, patients also face the risk of MIS-C, thrombosis, COVID-19-related neuroinflammation, long COVID-19 symptoms, and chronic inflammatory sequelae [14]. Recently, Bouwmans et al investigated post-COVID-19 conditions in adults with grade 4-5 CKD, dialysis, and kidney transplantation, and found that 24 % of the patients developed post-COVID-19 conditions like fatigue, dyspnea, muscle weakness, and cough [15]. The effectiveness of COVID-19 vaccination against long COVID-19 symptoms was investigated in a large international study and it was shown that vaccination reduced the risk of long COVID-19 symptoms [16].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 vaccination among adolescents and young adults with chronic kidney conditions: a single-center experience

Baltu,

Kurt-Sukur,

Tastemel Ozturk

et al. 2024

Klin Padiatr

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Background Following the pandemic of COVID-19, the main focus has been on COVID-19 vaccines and herd immunity. Although the safety of the COVID-19 vaccines has been shown in clinical trials, children with chronic diseases were not included. We investigated the side effect profile and safety of the COVID-19 vaccines in adolescents with kidney disease. Methods A questionnaire including demographic information, history of COVID-19, vaccination status, and vaccine-related side effects was administered to the patients with chronic kidney disease (CKD) stage 2–5, glomerular disease treated with immunosuppression, and kidney transplant recipients. Results Ninety-eight patients were vaccinated with CoronaVac-inactivated SARS-CoV-2 (n=16) or BNT162b2 messenger RNA (mRNA) COVİD-19 (n=82) vaccine. The mean age was 16.90±2.36 years. The most common side effects were local pain, fatigue, and fever. No serious side effects or renal disease flare were observed. There was no significant difference in the side effects reported after the BNT162b2 mRNA-RNA as compared to the Corona Vac-inactivated SARS-CoV-2 vaccine. No significant relationship was found between the frequency of side effects according to age, glomerular filtration rate, immunosuppressive treatments, CKD stage, and the underlying disease. Conclusion Although the reported data are subjective because they were obtained through a questionnaire and studies with long-term follow-up are needed, our early experience suggests that the vaccine is safe and adolescents and young adults should be encouraged to be vaccinated.

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“…Higher incidences of diabetes [68][69][70], hypertension [71], kidney disorders [72,73] among others have been reported in individuals post COVID-19 compared to non-COVID matched controls. Worsening of disease progression of existing clinical disorders have been reported in patients with hypertension [74,75], kidney disease [76], multiple sclerosis [77][78][79][80][81][82], dementia [83][84][85] and other neurological conditions [84][85][86][87][88][89] post COVID-19 compared to non-COVID matched controls. We expect that there will be accelerated aging of multiorgan systems in some individuals, especially those experienced severe acute COVID-19 and/or with major pre-existing comorbidities.…”

Section: New Clinical Disorders and Accelerated Disease Progressionmentioning

confidence: 99%

A Comprehensive Global Review of Epidemiology, Clinical Management, Socio-Economic Impacts and National Responses of Long COVID with Future Research Directions

Song,

Cui

et al. 2024

Preprint

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Background: Long COVID, characterized by a persistent symptom spectrum following SARS-CoV-2 infection, poses significant health, social, and economic challenges. This review aims to consolidate knowledge on its epidemiology, clinical features, and underlying mechanisms to guide global responses; Methods: We conducted a systematic literature review, analyzing peer-reviewed articles and reports to gather comprehensive data on long COVID’s epidemiology, symptomatology, and management approaches; Results: Our analysis revealed a wide array of long COVID symptoms and risk factors, with notable demographic variability. The current understanding of its pathophysiology suggests a multifactorial origin yet remains partially understood. Emerging diagnostic criteria and potential therapeutic strategies were identified, highlighting advancements in long COVID management.; Conclusion: This review highlights the multifaceted nature of long COVID, revealing a broad spectrum of symptoms, diverse risk factors, and the complex interplay of physiological mechanisms underpinning the condition. Long COVID symptoms and disorders will continue to weigh on healthcare systems in years to come. Ad-dressing long COVID requires a holistic management strategy that integrates clinical care, social support, and policy initiatives. The findings underscore the need for increased international cooperation in research and health planning to address the complex challenges of long COVID. There is a call for continued refinement of diagnostic and treatment modalities, emphasizing a multidisciplinary approach to manage the ongoing and evolving impacts of the condition.

show abstract

Post COVID-19 condition imposes significant burden in patients with advanced chronic kidney disease: A nested case-control study

Cited by 7 publications

References 32 publications

A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

A Comprehensive Review of the Global Epidemiology, Clinical Management, Socio-Economic Impacts, and National Responses to Long COVID with Future Research Directions

COVID-19 vaccination among adolescents and young adults with chronic kidney conditions: a single-center experience

A Comprehensive Global Review of Epidemiology, Clinical Management, Socio-Economic Impacts and National Responses of Long COVID with Future Research Directions

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