Post-COVID-19 cholangiopathy: A systematic review

Zippi, Maddalena; Fiorino, Sirio; Hong, Wandong; Biase, Dario de; Gallo, Claudio; Grottesi, Alfonso; Centorame, Annamaria; Ciarambino, Tiziana

doi:10.13105/wjma.v11.i1.29

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…On the other hand, infection increases calorie requirements, and in the absence of adequate dietary intake, this contributes to sarcopenia. Finally, the gastrointestinal and hepatic manifestations related to COVID-19 can further contribute to anorexia but also to the reduced assimilation of nutrients [ 41 , 42 ]. Sarcopenia is also related to bed rest secondary to COVID-19 symptoms, with loss of volume and muscle mass and functional impairment [ 43 , 44 ].…”

Section: Physical Decline In the Elderly And In Elderly With Covid-19mentioning

confidence: 99%

COVID-19 and Frailty

2023

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Older age is a major risk factor for adverse outcomes of COVID-19, potentially due to immunosenescence and chronic low-grade inflammation, both characteristics of older adults which synergistically contribute to their vulnerability. Furthermore, older age is also associated with decreased kidney function and is consequently associated with an increased risk of cardiovascular disease. All of this in the course of COVID-19 infection can worsen and promote the progression of chronic kidney damage and all its sequelae. Frailty is a condition characterized by the decline in function of several homeostatic systems, leading to increased vulnerability to stressors and risk of adverse health outcomes. Thus, it is very likely that frailty, together with comorbidities, may have contributed to the high vulnerability to severe clinical manifestations and deaths from COVID-19 among older people. The combination of viral infection and chronic inflammation in the elderly could cause multiple unforeseen harmful consequences, affecting overall disability and mortality rates. In post-COVID-19 patients, inflammation has been implicated in sarcopenia progression, functional activity decline, and dementia. After the pandemic, it is imperative to shine a spotlight on these sequelae so that we can be prepared for the future outcomes of the ongoing pandemic. Here, we discuss the potential long-term consequences of SARS-CoV-2 infection and its possibility of causing permanent damage to the precarious balance existing in the frail elderly with multiple pathologies.

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Section: Physical Decline In the Elderly And In Elderly With Covid-19mentioning

confidence: 99%

COVID-19 and Frailty

2023

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“…Vaccination against herpes zoster indirectly reduces the risk of associated mortality in the elderly [ 63 , 64 , 65 , 66 ]. On the other hand, it is known that the elderly population has paid a high price in terms of mortality, in terms of persistence of serious sequelae deriving from the COVID-19 pandemic, especially in the pre-vaccination era [ 67 , 68 , 69 , 70 , 71 , 72 , 73 ].In particular, variables commonly reported for adverse COVID-19 outcomes or increased frailty included age >75 (OR: 2.65, 95% CI: 1.81–3.90), male sex (OR: 2.05, 95% CI: 1.39–3.04), and severe obesity (OR: 2.57, 95% CI: 1.31–5.05). Active cancer (OR: 1.46, 95% CI: 1.04–2.04) was associated with an increased risk of serious outcomes.…”

Section: Mortality and Vaccines In The Elderlymentioning

confidence: 99%

Efficacy and Safety of Vaccinations in Geriatric Patients: A Literature Review

Ciarambino,

Crispino,

Buono

et al. 2023

Vaccines

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With the progressive lengthening of the average age of the population, especially in some countries such as Italy, vaccination of the elderly is a fixed point on which most of the public health efforts are concentrating as epidemic infectious diseases, especially those of the winter, have a major impact on the progression of severe disease, hospitalization, and death. The protection of the elderly against acute infectious diseases should not only limit mortality but also have a positive impact on the fragility of these people in terms of less disability and fewer care needs. However, vaccination of the elderly population differs in efficacy and safety compared to that of other population categories since aging and the consequent loss of efficiency of the immune system lead to a reduction in the immunogenicity of vaccines without achieving a lasting antibody coverage. There are various strategies to avoid the failure of immunization by vaccines such as resorting to supplementary doses with adjuvant vaccines, increasing the dosage of the antigen used, or choosing to inoculate the serum relying on various routes of administration of the vaccine. Vaccination in the elderly is also an important factor in light of growing antibiotic resistance because it can indirectly contribute to combating antibiotic resistance, reducing theoretically the use of those agents. Furthermore, vaccination in old age reduces mortality from infectious diseases preventable with vaccines and reduces the same rate of resistance to antibiotics. Given the importance and complexity of the topic, in this review, we will deal with the main aspects of vaccination in the elderly and how it can influence mortality and healthcare costs, especially in those countries where population aging is more evident. Therefore, we conducted a systematic literature search in PubMed to identify all types of studies published up to 31 May 2023 that examined the association between vaccination and the elderly. Data extraction and quality assessment were conducted by two reviewers (PC and TC) who independently extracted the following data and assessed the quality of each study.

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Post-COVID-19 cholangiopathy: A systematic review

Cited by 2 publications

References 55 publications

COVID-19 and Frailty

COVID-19 and Frailty

Efficacy and Safety of Vaccinations in Geriatric Patients: A Literature Review

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