Post-COVID-19 arthritis: is it hyperinflammation or autoimmunity?

Taha, Sara; Samaan, Sara; Ibrahim, Rehab Ali; El-Sehsah, Eman M; Youssef, Mariam

doi:10.1684/ecn.2021.0471

Cited by 33 publications

(57 citation statements)

References 31 publications

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“…Additionally, fatigue (r = 0.438, P = .001), duration of hospitalization (r = 0.297, P = .004), and duration of O2 support (r = 0.235, P = .025) were positively correlated with post-COVID syndrome. In a review, abnormal in ammation and IL6/IL10 imbalance were revealed to play a role in post-COVID syndrome (21). In the current study, there was no correlation between IL6 (r = 0.083, P = .437), IL10 (r = 0-.036, P = .734), the IL6/IL10 ratio (r = 0.160, P = .130), and post-COVID syndrome.…”

Section: Discussioncontrasting

confidence: 58%

“…It is thought that CRP, IL6 and IL10 levels increase together after immune activation and are associated with prognosis. Several studies found high levels of C-Reactive protein (CRP), interleukin 6 (IL6), and interleukin 10 (IL10) to be associated with severe disease and musculoskeletal manifestations (19)(20)(21)(22). Existing research demonstrates that there may be a connection between anosmia and post-COVID syndrome because of the blockage of lymphatic drainage.…”

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confidence: 99%

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Musculoskeletal Manifestations, Post-COVID Syndrome, Relationship with Laboratory Parameters in Hospitalized Patients Infected with COVID-19

Kuculmez

Gençtoy

Arikan

2022

Preprint

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Background: This study aims to characterize the prevalence of musculoskeletal manifestations in hospitalized COVID-19 patients and the relationship between C-Reactive protein (CRP) and interleukin levels. Methods: A medical records review study was performed on patients at Baskent University between March 7 and December 31, 2020. The study included hospitalized patients above 18 years diagnosed with COVID-19 by polymerase chain reaction. Pregnant individuals, those with end-stage disease or missing documentation were excluded. Patient demographics and laboratory results were obtained from electronic health records and previous study performed in the same hospital. The relationship between musculoskeletal manifestations, CRP, and interleukin levels were determined. A Pvalue of less than .05 was consideredstatistically significant. Results: Totally, 109 patients were analyzed; 34.86% (n = 38) of the patients had arthralgia, 1.83% (n = 2) had arthritis, 41.28% (n = 45) underwentfatigue, and 32.11% (n = 35) experiencedpost-COVID syndrome. There was no correlation between musculoskeletal manifestations, CRP, and interleukin levels (P > .05). There was positive correlation between post-COVID syndrome, fatigue, duration of O2 support, duration of hospitalization (P < .05), and the patients were elderly. CRP levels were positively correlated with duration of hospitalization, duration of O2 support, history of intensive care, and duration of intensive care (P < .05). Interleukin 6 levels were positively correlated with CRP levels, duration of hospitalization, and O2 support duration (P < .05), but there was no correlation with interleukin 10 levels (P > .05). Conclusion: There was no correlation between musculoskeletal manifestations, CRP, and interleukin levels. Patients who are hospitalized, elderly, abnormally fatigued, or O2 supported should be followed for post-COVID syndrome.

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Section: Discussioncontrasting

confidence: 58%

mentioning

confidence: 99%

Musculoskeletal Manifestations, Post-COVID Syndrome, Relationship with Laboratory Parameters in Hospitalized Patients Infected with COVID-19

Kuculmez

Gençtoy

Arikan

2022

Preprint

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“…However, this frequency might have been lower due to steroid therapy in COVID-19 pneumonia [ 46 ]. Other authors found that post-COVID-19 was strongly associated with the erythrocyte sedimentation rate and C-reactive protein, but not autoantibodies, which suggested an inflammatory rather than autoimmune mechanism of arthritis [ 47 ]. This could also explain the significantly increased number of new Kawasaki disease cases during the COVID-19 pandemic [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

How Did the Two Years of the COVID-19 Pandemic Affect the Outcomes of the Patients with Inflammatory Rheumatic Diseases in Lithuania?

et al. 2023

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Background and objectives: the COVID-19 pandemic globally caused more than 18 million deaths over the period of 2020–2021. Although inflammatory rheumatic diseases (RD) are generally associated with premature mortality, it is not yet clear whether RD patients are at a greater risk for COVID-19-related mortality. The aim of our study was to evaluate mortality and causes of death in a retrospective inflammatory RD patient cohort during the COVID-19 pandemic years. Methods: We identified patients with a first-time diagnosis of inflammatory RD and followed them up during the pandemic years of 2020–2021. Death rates, and sex- and age-standardized mortality ratios (SMRs) were calculated for the prepandemic and pandemic periods. Results: We obtained data from 11,636 patients that had been newly diagnosed with inflammatory RD and followed up until the end of 2021 or their death. The mean duration of the follow-up was 5.5 years. In total, 1531 deaths occurred between 2013 and 2021. The prevailing causes of death in the prepandemic period were cardiovascular diseases, neoplasms, and diseases of the respiratory system. In the pandemic years, cardiovascular diseases and neoplasms remained the two most common causes of death, with COVID-19 in third place. The SMR of the total RD cohort was 0.83. This trend was observed in rheumatoid arthritis and spondyloarthropathy patients. The SMR in the group of connective-tissue diseases and vasculitis was higher at 0.93, but did not differ from that of the general population. The excess of deaths in the RD cohort during the pandemic period was negative (−27.2%), meaning that RD patients endured the pandemic period better than the general population did. Conclusions: The COVID-19 pandemic did not influence the mortality of RD patients. Strict lockdown measures, social distancing, and early vaccination were the main factors that resulted in reduced mortality in this cohort during the pandemic years.

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“…Bei 100 ägyptischen Patienten wurden 6 Monate nach Abschluss der akuten Covid-19-Phase verschiedene Entzündungs- und Autoimmunmarker untersucht [ 5 ]. Die Prävalenz einer Post-Covid-Arthritis lag bei 37 %.…”

Section: Definitionen Symptomatologie Klinikunclassified

Hyperthermie – eine Behandlungsmöglichkeit bei Long-Covid?

Stange¹

2022

Zeitschrift für Komplementärmedizin

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SummaryErschöpfung sowie chronische Entzündungsprozesse sind häufige Symptome von Long-Covid. Die Hyperthermie wurde bereits auf ihre entzündungshemmenden Effekte bei Erkrankungen wie Rheuma oder Psoriasis-Arthritis erprobt. Die bisherigen klinischen Ergebnisse deuten darauf hin, dass Hyperthermie auch bei Long-Covid-Patienten eine Behandlungsoption darstellt, insbesondere wenn bei den Betroffenen eine chronisch-entzündliche Komponente nachgewiesen ist.

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Post-COVID-19 arthritis: is it hyperinflammation or autoimmunity?

Cited by 33 publications

References 31 publications

Musculoskeletal Manifestations, Post-COVID Syndrome, Relationship with Laboratory Parameters in Hospitalized Patients Infected with COVID-19

Musculoskeletal Manifestations, Post-COVID Syndrome, Relationship with Laboratory Parameters in Hospitalized Patients Infected with COVID-19

How Did the Two Years of the COVID-19 Pandemic Affect the Outcomes of the Patients with Inflammatory Rheumatic Diseases in Lithuania?

Hyperthermie – eine Behandlungsmöglichkeit bei Long-Covid?

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