Post-Concussion Syndrome after a Mine Blast Injury: Neuropsychological Consequences and Changes of the Cognitive Evoked Potentials (P 300)

Hostilities in the East of Ukraine are characterized by the use of new weapons, including rocket artillery, rocket-propelled grenades and landmines. This has led to an increase in the number of victims with blast mild traumatic brain injury (BMTBI) and the need to provide them with effective assistance and rehabilitation. An important task is to improve the BMTBI diagnosis by specifying the objective criteria for structural and functional disorders of the central nervous system. This will improve the prognosis of the course of BMTBI in the injured and the treatment program, including personalized, to prevent the development of persistent neurological deficit. Objective: to investigate the possibilities of the cognitive evoked potentials (CEP) method for the objective diagnosis of cognitive disorders in post-concussion syndrome (PCS) BMTBI. Materials and methods. The study involved 115 men with PCS (main group) and 30 healthy individuals (control group). The cognitive functions of the study participants were studied using the questionnaire "Cicerone". The neurophysiological method for assessing the functional state of the brain involved the registration of CEP, event-related (P300 CEP). Results. The selection of a subgroup of patients with PCS, characterized by a predominance of cognitive impairments, allowed us to trace the relationship between the results of neurophysiological studies with the cognitive indicators of patients with BMTBI. P300 latency indices are inversely proportional to cognitive assessment the questionnaire "Cicerone" and statistically significantly depend on the severity of cognitive impairment. Conclusions. The CEP P300 method can be an effective means of objectifying the degree of cognitive impairment in patients with PCS due to BMTBI.

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“…The main results of our clinical and neurological, neuropsychological and neurophysiological studies have been published previously [18,19].…”

Section: Methodsmentioning

confidence: 99%

Cognitive evoked potentials in the diagnosis of post-concussion syndrome due to blast mild traumatic brain injury

Zavaliy¹,

Solonovych²,

Biloshytsky³

et al. 2021

Ukr Neurosurg J

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“…В низці як вітчизняних, так і іноземних досліджень динаміка розвитку патоморфологічних змін після черепно-мозкової травми різного ґенезу представлена досить ретельно з погодинними, щодобовими та щотижневими характеристиками [20,21,22]. Але це не стосувалося вибухо-індукованої нейротравми.…”

Section: результати дослідженняunclassified

Explosion-Induced Neurotrauma (Pathophysiological and Patomorphological Features)

Kozlova¹,

Koldunov²,

Aleksjejenko³

et al. 2021

Ukr. ž. med. bìol. sportu

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The article presents the results of pathophysiological and pathomorphological features which were studied in experimental blust-induced neurotrauma in rats. The relevance of this study is associated with the frequent blust neurotrauma resulting from the use of explosives in military conflicts. At the same time, neurotrauma is more common, which is clinically manifested by cognitive impairment, even with mild and moderate severity. This, in turn, leads to complications and disability for young people. The purpose of the work was to study the consequences of the air-shock wave influence on the functional and morphological states of the central nervous system. Materials and methods. The studies were carried out on 36 white male Wistar rats 5-7 months old, weighing 180-220 g. The rats were divided into two groups: I – experimental group (n=18), the animals of which were anesthetized with halothane, fixed and explosion-induced neurotraum was simulated by generating a baroacoustic wave with an excess pressure of 26.4 ± 3.6 kPa. II group was a control group (n=18). Functional changes were investigated in the Barnes maze. For pathomorphological examination, brain sections were stained with hematoxylin and eosin. The animals were kept in standard conditions and in the standard diet of the vivarium, all studies were conducted in accordance with modern international requirements and norms of humane treatment of animals (Council of Europe Convention dated 18.03.1986 (Strasbourg); Helsinki Declaration 1975, revised and supplemented in 2000, Law of Ukraine dated 21.02.2006 No. 3447-IV), which is evidenced by an extract from the protocols of the meeting of the commission on biomedical ethics. Results and discussion. Analysis of the results of memory studies in the Barnes maze showed a significant (Р <0.05) increase in the latent time of entering the shelter in rats of the experimental group in the acute and early post-traumatic period, which indicates memory impairment. General characteristics of the rats behavior in the experimental group showed an increase in anxiety and disorientation. The increase in research on "fake shelters" and the chaotic movement around the facility was evidenced. Analysis of frontal histological sections of the rat brain in the dynamics of the explosion-induced neurotrauma development showed the presence of characteristic signs in the form of diffuse microhemorrhages in the hippocampus zone in the acute period of injury, diffuse areas of perivascular and pericellular edema in the early post-traumatic period and paretic dilated capillaries in the structure of the cerebral region on 2nd-3rd week of the post-traumatic period. Conclusion. Thus, quantitative (increased latent time) and qualitative (increased anxiety) signs of impaired orientational-spatial memory and the development of specific pathomorphological signs of explosive brain damage in rats of the experimental group were established

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Post-Concussion Syndrome after a Mine Blast Injury: Neuropsychological Consequences and Changes of the Cognitive Evoked Potentials (P 300)

Cited by 2 publications

References 8 publications

Cognitive evoked potentials in the diagnosis of post-concussion syndrome due to blast mild traumatic brain injury

Cognitive evoked potentials in the diagnosis of post-concussion syndrome due to blast mild traumatic brain injury

Explosion-Induced Neurotrauma (Pathophysiological and Patomorphological Features)

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