Post-concussion symptoms after traumatic brain injury at 3 and 12 months post-injury: A prospective study

Sigurðardóttir, Sólrún; Anđelić, Nada; Røe, Cecilie; Jerstad, Tone; Schanke, Anne‐Kristine

doi:10.1080/02699050902926309

Cited by 187 publications

(127 citation statements)

References 37 publications

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“…One possible explanation for the increase in symptoms is that individuals with severe TBI may be less aware of their deficits for organic reasons, and thus these individuals may under-report symptoms during the first months post-injury (40). When the RPQ was added into the regression analysis, it was a significant predictor of HRQL.…”

Section: Discussionmentioning

confidence: 98%

Health-related Quality of Life 12 months after severe traumatic brain injury: A prospective nationwide cohort study

Søberg¹,

Røe²,

Anke³

et al. 2013

J Rehabil Med

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Objective: To assess health-related quality of life in individuals with severe traumatic brain injury at 12 months postinjury, applying the Quality of Life after Brain Injury (QO-LIBRI) instrument, and to study the relationship between injury-related factors, post-injury functioning and healthrelated quality of life. Design/subjects: The study is part of a prospective, Norwegian multicentre study of adults (≥ 16 years old) with severe traumatic brain injury, as defined by a Glasgow Coma Scale score of 3-8 during the first 24 h post-injury. A total of 126 patients were included. Methods: Socio-demographic data and injury severity variables were collected. Functioning at 3 and 12 months was assessed with the Glasgow Outcome Scale Extended (GOSE), the Functional Independence Measure (FIM), the Rivermead Post-concussion Questionnaire (RPQ), and the Hospital Anxiety and Depression Scale (HADS). Hierarchical regression analysis was applied.

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Section: Discussionmentioning

confidence: 98%

Health-related Quality of Life 12 months after severe traumatic brain injury: A prospective nationwide cohort study

Søberg¹,

Røe²,

Anke³

et al. 2013

J Rehabil Med

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“…In most patients, cognition recovers and PCS resolve within three months. However, up to 25% of patients (Sigurdardottir et al, 2009) suffer residual PCS, long-term impairment, and sometimes disability (Levin, 2009), so that efficient identification of alterations due to mTBI becomes particularly important. Several cognitive functions are affected by mTBI, including attention (De Monte et al, 2006;Vanderploeg et al, 2005) working memory (Vanderploeg et al, 2005), episodic memory (Tsirka et al, 2011), verbal learning (De Monte et al, 2006;Ruff et al, 1989), and visual memory (Levin et al, 1987;Raskin, 2000;Ruff et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury

Antonakakis

Dimitriadis

Zervakis

et al. 2016

International Journal of Psychophysiology

122

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Cross-frequency coupling (CFC) is thought to represent a basic mechanism of functional integration of neural networks across distant brain regions. In this study, we analyzed CFC profiles from resting state Magnetoencephalographic (MEG) recordings obtained from 30 mild traumatic brain injury (mTBI) patients and 50 controls. We used mutual information (MI) to quantify the phase-to-amplitude coupling (PAC) of activity among the recording sensors in six nonoverlapping frequency bands. After forming the CFC-based functional connectivity graphs, we employed a tensor representation and tensor subspace analysis to identify the optimal set of features for subject classification as mTBI or control. Our results showed that controls formed a dense network of stronger local and global connections indicating higher functional integration compared to mTBI patients.Furthermore, mTBI patients could be separated from controls with more than 90% classification accuracy. These findings indicate that analysis of brain networks computed from resting-state MEG with PAC and tensorial representation of connectivity profiles may provide a valuable biomarker for the diagnosis of mTBI.

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“…The number and severity of symptoms were collected using the Rivermead Post-Concussion symptoms Questionnaire (RPQ; [60][61][62]), as in previous studies [11,14,21,39,40,53,63]. PCS was diagnosed if participants reported that three (or more) of the symptom categories listed in the ICD-10 criteria were more of a problem after the head injury.…”

Section: Diagnosismentioning

confidence: 99%

Post-concussion syndrome: Prevalence after mild traumatic brain injury in comparison with a sample without head injury

2011

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Primary Objective: To compare the prevalence of persistent post-concussion syndrome (PCS; > 1 year post-injury) in participants with mild traumatic brain injury (mTBI) and those without head injury.Research Design: Cross-sectional sample of 119 participants with mTBI and 246 without previous head injury.Methods: Online questionnaires collected data about post-concussion symptoms, cognitive failures, anxiety, depression, sleep behaviour and post-traumatic stress disorder. Variability within the sample was addressed by splitting by PCS diagnosis to create four groups: mTBI+PCS, mTBI-PCS, Control+PCS and Control-PCS. PCS was diagnosed using ICD-10 criteria in all groups, with controls not requiring previous head injury. Main Outcomes and Results: PCS was present to a similar extent in participants with no head injury (34%) compared to those with mTBI (31%). Only report of headaches, which could be caused by expectation bias, distinguished between mTBI+PCS and Control+PCS groups. In addition, significantly higher cognitive problems were observed in participants with mTBI compared with the control group Conclusions: Persistent PCS, as currently defined, is not specific to mTBI. These data suggest that somatic and cognitive symptoms are most likely to be able to distinguish PCS after mTBI from that present in the general population. Further research is necessary into these factors in order to create more specific PCS diagnostic criteria. PCS in populations with and without mTBI 3

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Post-concussion symptoms after traumatic brain injury at 3 and 12 months post-injury: A prospective study

Abstract: PCS symptoms were reported to a greater degree in persons with mild TBI at 3 months post-injury. One year after injury, no differences were found between TBI groups on the presence of PCS.

Cited by 187 publications

References 37 publications

Health-related Quality of Life 12 months after severe traumatic brain injury: A prospective nationwide cohort study

Health-related Quality of Life 12 months after severe traumatic brain injury: A prospective nationwide cohort study

Altered cross-frequency coupling in resting-state MEG after mild traumatic brain injury

Post-concussion syndrome: Prevalence after mild traumatic brain injury in comparison with a sample without head injury

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