“…There was much aspiration for its potential value in correcting gynec o p a t h y and andropathic states, thus stimulating an ambitious endeavor to synthesize more potent and longer acting congeners (26,27). In spite of the considerable success achieved in generating these highly potent LH-releasing analogues, additional testing undoubtedly confirmed the antireproductive nature of this class of compounds, and further corroborated the direct relationship to their agonist properties (14,15). T h e various hormonal and receptor studies begin to explain the mechanisms by which the excessive and inappropriate hypophysial stimulation fraught by the "super" analogues is injurious to the reproductive integrity of the animal, be it female or male, immature or mature, and why, in a considerable number of clinical studies, the analogues are truly incapable of significantly ameliorating or reversing the infertile or hypogonadal state (15).…”