Post-coital antifertility activity of Achyranthes aspera Linn. root

Vasudeva, Neeru; Sharma, Sunny

doi:10.1016/j.jep.2006.03.009

Cited by 59 publications

(39 citation statements)

References 5 publications

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“…Embryonal resorption could be due to modifications of uterine lining function or maternal toxicity which consequently may increase early resorption and late fetal death (Chaves, 1985; Khera, 1987). Hence, the present investigation clearly reveals that the extracts are effective before and after the implantation occurs (Vasudeva and Sharma, 2006). …”

Section: Anti-implantation and Abortifacient Activitiessupporting

confidence: 61%

“…The reduced level of hormone may also be due to inactivation of luteinization of ovarian follicles, which could be responsible for the reduction in the concentration of serum progesterone in this study [14,[22][23][24][25][26][27][28]. An elevated level of progesterone during pregnancy plays a key role in maintaining the conditions and is an important factor in the implantation process.…”

Section: Hormonal Analysismentioning

confidence: 99%

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Evaluate the Antifertility Potential of Ficus Racemosa Linn Bark in Female Wistar Rats

Shah¹

2016

Asian J Pharm Clin Res

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Objective: The present study was formulated to evaluate the antifertility potential of Ficus racemosa Linn bark on female Wistar rats.Methods: Effects of F. racemosa bark extract were studied on physicochemical parameters, successive solvent extraction, and phytochemical screening and antifertility activity. After acute oral toxicity study, antifertility activity in proven fertile female Wistar rats at the doses 500 mg/kg b.wt./day for 30 days. Effects on dimensions of the reproductive outcome, anti-implantation, abortifacient, estrogenic, and antiestrogenic activity were observed.Results: Phytochemical studies of F. racemosa bark shown a positive test for alkaloids, steroid, flavonoids, terpene, carbohydrates, and tannin. The extract of F. racemosa has the antifertility effect; the control rats showed a good number of litters. Treatment of animal with different extracts resulted a significant (p<0.05, p<0.01). Antifertility activity of 56.5% and 40.3% was exhibited by alcoholic F. racemosa extract (AFR) and aqueous F. racemosa Extract (WFR), respectively. After 21 days of the extract-free period, the antifertility effect of the extracts was reversed. The extract treatment with AFR, an increase in the percentage of resorption index indicates the failure in development of embryo. The mean percentage of anti-implantation and percent resorption (abortifacient) was found to be highest for AFR-41.21%, WFR 28.07, and AFR-32.56%, WFR-20.76%, respectively. The decrement in implantation caused by the extracts may be due to estrogenic or antiestrogenic activity. However, along with standard, AFR exhibiting more potent estrogenic and less potent antiestrogenic when compared with standard. Conclusion:The above results revealed the potential, reversible female antifertility effect of alcoholic extract F. racemosa bark.

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Section: Anti-implantation and Abortifacient Activitiessupporting

confidence: 61%

Section: Hormonal Analysismentioning

confidence: 99%

Evaluate the Antifertility Potential of Ficus Racemosa Linn Bark in Female Wistar Rats

Shah¹

2016

Asian J Pharm Clin Res

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“…Dry leaves are employed against asthma (Singh 1995). Ethanol extract of plant roots possesses anti-inflammatory, anti-implantation and abortifacient activity (Vasudeva & Sharma 2006). Plant extract shows activity against Bacillus bacteria (Risal 1994).…”

Section: Prickly Chaff Flower (E)mentioning

confidence: 99%

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Kunwar

Uprety

Burlakoti

et al. 2009

Ethnobot. Res. App.

304

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Ethnopharmacological knowledge is common and import among tribal populations but much of the information is empirical at best lacking scientific validation. Despite widespread use of plant resources in traditional medicines, bioassay analysis of very few plant species have been conducted to investigate their medicinal properties, and to ascertain safety and efficacy of traditional remedies. The present study analyses indigenous uses of medicinal plants of far-west Nepal and compares with earlier ayurveda studies, phytochemical assessments and pharmacological actions. A field study was carried out in Baitadi and Darchula districts of far-west Nepal. Group discussions, informal meetings, questionnaire surveys and field observations were employed for primary data collection. Voucher specimens were collected with field notes and codes and deposited at Tribhuvan University Central Herbarium (TUCH), Kathmandu. Only 50% of species surveyed shared common uses with ayurvedic medicine. This implies that these herbal remedies are part of an independent health care system in the Nepal Himalaya, which is indigenous and influenced by ayurveda. The folk uses of some of the species were contradicting to those of ayurveda and phytochemical bioassays. A detailed phytochemical study on those species would be an important line of research. IntroductionMedicinal plants help in alleviating human suffering and are widely used for subsistence, home remedies, and trade (Kunwar et al. 2006). It is estimated that 70-80% of people worldwide rely on traditional herbal medicine to meet their primary health care needs (Farnsworth & Soejarto 1991). The ayurveda is an ancient traditional system of medicine with remedies for health and alleviation of illness. The acceptance of the ayurveda is gearing up and use of indigenous drugs of natural/plant origin is a maPublished: January 16, 2009 Ethnobotany Research & Applications 6www.ethnobotanyjournal.org/vol7/i1547-3465-07-005.pdf cuna pruriens (L.) DC. for Parkinson's disease, Commiphora as a hypolipidemic, Asclepias as cardiotonic, psoralens for vitiligo, curcumines for inflammation, baccoside for mental retention, picrosides for hepatoprotective, diosgenin for the synthesis of steroidal hormones, guggulsterons as hypolipidemic, piperidine as bioavailability enhancers, asarone as hallucinogenic, phyllanthins as anti-virals, withanolides and many other steroidal lactones and their glycosides as immunomodulators (Jain 1994, Patwardhan 2000. As an example, the sale of drugs derived from the plant Taxus The increasing use of traditional therapies demands more scientifically sound evidence for the principles behind therapies and for effectiveness of medicines (Patwardhan et al. 2005). The therapies are often criticized due to dearth of research, critical evaluation, in vivo studies and validations (Fong 2002, Houghton 1995 to support the safety of uses. At the same time, ethnopharmacological knowledge is percolating down these days among the tribal population. The present study, therefore aim...

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“…And also study was made on hydroethanolic, n-hexane and chloroform extracts, which were found to be most effective for sperm immobilization, sperm viability, acrosome status, 5'-nucleotidase activity and nuclear chromatin decondensation. Vasudeva and Sharma [11] reported that, ethanolic extract of the root of A. aspera shows post coital antifertility activity in female albino rats. But so far, no one reported systematic investigation on leaves of A. aspera MeOH extract to know the testicular activities at lower doses on albino mice.…”

Section: Introductionmentioning

confidence: 99%

Testicular Activity of Mice Treated With MeOH Extract of Achyranthes aspera Leaves

Kamble

Reddy

Patil³

2017

Journal of Advanced Medical Sciences and Applied Technologies

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Objectives:In India control of fertility is based on the folk use of numerous Indian Traditional Plants that has been practiced for contraception from many years. Present investigation aims that, to evaluate the contraceptive potential of Achyranthes aspera leaves MeOH extract in male albino mice and has shown promising results of antispermatogenic, antiandrogenic and hypolipidaemic activities. Materials & Methods:MeOH extract of A. aspera leaves at the doses of 25 mg and 50 mg/100 gm body weight was administered orally for 30 days to adult male albino mice. On day 31st, the rats were sacrificed and the testis were removed and weighed for gravimetrical analysis. Organs were processed for biochemical estimation, histological evaluation and histomorphometry for testicular analysis.Results: Treatment with A. aspera leaves extract resulted in decrease the weight of testis 0.925±0.015 significantly (P<0.05). Morphometric analysis like diameter of testis 2554.22±18.545 seminiferous tubules 247.074±8.051 and Leydig cells 7.842±0.248 were decreased significantly (P<0.05) at 50mg/100gm body weight when compare to control. Spermatogenic elements like, spermatogonia, spermatocytes and spermatids in the testis were reduced significantly (P<0.05) as well as Leydig cells count in testis when compared to control. Biochemical analysis resulted as, protein, glycogen, and cholesterol content were decreased significantly (P<0.05) in testis of extracts treated mice, whereas alkaline phosphatase increased and acid phosphatase decreased when compared with that of control. Conclusion:MeOH extract of A. aspera leaves arrest the spermatogenesis and inhibited testicular function in male mice without side effects to act as potential contraceptive.

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Post-coital antifertility activity of Achyranthes aspera Linn. root

Cited by 59 publications

References 5 publications

Evaluate the Antifertility Potential of Ficus Racemosa Linn Bark in Female Wistar Rats

Evaluate the Antifertility Potential of Ficus Racemosa Linn Bark in Female Wistar Rats

Indigenous Use and Ethnopharmacology of Medicinal Plants in Far-West Nepal

Testicular Activity of Mice Treated With MeOH Extract of Achyranthes aspera Leaves

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