Post-Chikungunya Rheumatoid Arthritis, Saint Martin

Foissac, Maud; Javelle, Émilie; Ray, Simon; Guérin, B; Simon, Fabrice

doi:10.3201/eid2103.141397

Cited by 37 publications

(38 citation statements)

References 8 publications

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“…In most cases of CHIKV infection, patients develop symmetric oligo or polyarthralgia within minutes to days following the initial onset of fever [9, 18, 40]. While any joint can be affected, those that are most commonly reported are the distal extremities such as wrists, metacarpal and interphalangeal joints, as well as the ankles and metatarsophalangeal joints [18, 20, 36, 40, 41], though some studies have indicated that the knee is also commonly affected [9, 31, 36, 42].…”

Section: Joint Diseasementioning

confidence: 99%

“…While any joint can be affected, those that are most commonly reported are the distal extremities such as wrists, metacarpal and interphalangeal joints, as well as the ankles and metatarsophalangeal joints [18, 20, 36, 40, 41], though some studies have indicated that the knee is also commonly affected [9, 31, 36, 42]. While the majority of cases have this distribution, it is important to recognize that patient presentation can vary and include asymmetric polyarthritis, monoarthralgia, and involvement of less commonly affected joints, such as the elbow, hip, and shoulder, as well as vertebral pain in sacroiliac, lumbosacral, and cervical regions [9, 43, 44].…”

Section: Joint Diseasementioning

confidence: 99%

“…Several vaccines are in various stages of development, though none are yet commercially available [10-16]. Treatments are generally symptomatic and supportive, and the efficacies of potentially more specific therapies are currently unknown [17, 18]. …”

Section: Introductionmentioning

confidence: 99%

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A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis

Goupil

2016

TORJ

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Background:Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that circulates predominantly in tropical and subtropical regions, potentially affecting over 1 billion people. Recently, an outbreak began in the western hemisphere and has resulted in over 1.8 million reported suspected cases. Infection often results in severe fever, rash and debilitating polyarthralgia lasting weeks to months. Additionally, the current literature reports that CHIKV can result in a severe chronic arthralgia and/or arthritis that can last months to years following the initial infection.Objective:The purpose of this review is to evaluate the literature and summarize the current state of knowledge regarding CHIKV-associated disease, including clinical presentation, diagnosis, risk factors for development of severe disease, treatment, and pathogenesis in human patients. Additionally, recommendations are presented regarding avenues for clinical research to help further elucidate the pathogenesis of joint disease associated with CHIKV infection.Conclusion:While there is an association between initial CHIKV infection and acute disease, a causal relationship with development of chronic arthralgia has not been established at this time. Potential causes of chronic CHIKV-induced arthritis have been postulated, including viral persistence, induction of autoimmune disease, and exacerbation of pre-existing joint disease. While there are numerous reports of chronic CHIKV-associated arthralgia and/or arthritis, there is currently no evidence of a definitive link between initial infection and development of chronic disease. Additional, prospective clinical research on CHIKV-associated disease is necessary to further determine the potential role of virus and development of chronic joint disease.

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Section: Joint Diseasementioning

confidence: 99%

Section: Joint Diseasementioning

confidence: 99%

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A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis

Goupil

2016

TORJ

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“…Chronic rheumatoid-like polyarthritis known as PCCA that sometimes leads to destructive arthropathy occurs in around 5.6z of patients after acute CHIKV infection (14). PCCA was previously reported after an East/ Central/South African (ECSA) genotype infection, but a case of PCCA caused by the Asian genotype, as well as our case, was also reported in Saint Martin in the Caribbean islands in 2013 (15). Therefore, it is important to consider that the epidemic Asian genotypes could be a causative pathogen for PCCA.…”

Section: Discussionmentioning

confidence: 92%

Chikungunya Fever in Japan Imported from the Caribbean Islands

et al. 2016

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SUMMARY:A 53-year-old Japanese woman who was working as a volunteer in the Commonwealth of Dominica in the Caribbean islands presented with a high-grade fever and severe incapacitating generalized arthralgia. The Asian genotype of the chikungunya virus was confirmed using reverse transcription-PCR and serology, based on the presence of a specific neutralization titer and immunoglobulin M antibodies. She was diagnosed with post-chikungunya chronic arthritis based on persistence of her polyarthritis for 3 months and the presence of rheumatoid factor, immunoglobulin G-rheumatoid factor, and matrix metalloproteinase-3. Chikungunya virus should be considered as a causative pathogen in travelers returning from Caribbean islands. Clinicians should consider chikungunya fever in the differential diagnosis of patients who complain of chronic arthritis and have a history of travel to an endemic area.

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“…A notable clinical feature of chikungunya is the persistence of joint symptoms for weeks to months, including a syndrome of post-chikungunya chronic infl ammatory rheumatism (10) . Among patients recruited from the outbreak on Reunion Island, older age, severity of presentation, and CHIKV-specifi c immunoglobulin G (IgG) titers were predictors of persistent symptoms (11) .…”

Section: Discussionmentioning

confidence: 99%

A case of chikungunya virus disease presenting with remarkable acute arthritis of a previously damaged finger joint

Eyer-Silva

Neto²,

Silva

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Chikungunya virus (CHIKV) is a mosquito-borne arthritogenic alphavirus that has recently been introduced to Brazil. We report the case of a 36-year-old male patient from the City of Rio de Janeiro who developed molecularly-confi rmed CHIKV disease and whose clinical picture was remarkable because of acute arthritis of an interphalangeal joint that had been damaged by trauma 8 years previously. This case illustrates that acute CHIKV disease may preferentially target previously damaged joints. Careful study of individual cases may provide valuable information on the presentation and management of this emerging zoonosis in Brazil.

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Post-Chikungunya Rheumatoid Arthritis, Saint Martin

Cited by 37 publications

References 8 publications

A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis

A Review of Chikungunya Virus-induced Arthralgia: Clinical Manifestations, Therapeutics, and Pathogenesis

Chikungunya Fever in Japan Imported from the Caribbean Islands

A case of chikungunya virus disease presenting with remarkable acute arthritis of a previously damaged finger joint

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