Post-chemotherapy Changes in Bone Marrow in Acute Leukemia With Emphasis on Detection of Residual Disease by Immunohistochemistry

Ayyanar, Pavithra; Kar, Rakhee; Dubashi, Biswajit; Basu, Debdatta

doi:10.7759/cureus.20175

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…Presence of cluster of immature cells is usually concerning for residual leukemic blasts. Ayyana, et al reported small and large clusters of immature cells are present in 12 out of 18 (66.7%) acute leukemia patients in sustained remission [15]. Similar to their observations, we found three cases in our study where small and large clusters of immature B-cells are present but proven to be B-ALL in remission without MRD by MFC and ClonoSEQ.…”

Section: Phenotypic Features Of B-all Mrdsupporting

confidence: 91%

Comparison of Multiparameter Flow Cytometry and ClonoSEQ Studies for Precursor B-Lymphoblastic Leukemia Minimal Residual Disease Detection on Bone Marrow Samples

Nouran¹,

Joseph²,

Fu³

et al. 2023

Advances Leuk Res Treat

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Section: Phenotypic Features Of B-all Mrdsupporting

confidence: 91%

Comparison of Multiparameter Flow Cytometry and ClonoSEQ Studies for Precursor B-Lymphoblastic Leukemia Minimal Residual Disease Detection on Bone Marrow Samples

Nouran¹,

Joseph²,

Fu³

et al. 2023

Advances Leuk Res Treat

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“…A study found that only 2.6% of patients had bone marrow fibrosis after induction therapy. Similarly, the bone marrow fibrosis of the patients in our study returned to normal except for one patient (5.5%) [14,26].…”

Section: The European Researchsupporting

confidence: 68%

The relationship of bone marrow fibrosis at diagnosis with prognosis and survival in childhood acute lymphoblastic leukemia

Özdemir

Kar

Eroğlu

et al. 2023

The European Research Journal

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Objectives: Our aim in this study is to investigate the effect of fibrosis at diagnosis on treatment and survival in childhood acute lymphoblastic leukemia (ALL). Methods: This study is retrospective. We evaluated the relationship between patients' age, white blood cell count at diagnosis, morphological blast percentage and flow cytometric blast percentage at diagnosis, day 15th and day 33th, absolute blast count in peripheral smear on day 8th, and the degree of fibrosis in bone marrow biopsy at diagnosis in 36 pediatric patients. The fibrosis degree in biopsy on the thirty-third day after induction therapy was measured. Results: Twenty-eight (77.8%) cases were diagnosed B-ALL and 8 T-ALL (22.2%). There was no statistically significant difference between the groups with and without fibrosis in terms of any parameter measured at the time of diagnosis, 8th day, 15th day, and 33th day. No significant difference was found between the groups according to overall survival (OS): the mean OS was 50.22 ± 5.44 months in the fibrosis group and 49.70 ± 3.96 months in the non-fibrosis group (p = 0.557). Conclusions: There is a high detection rate of bone marrow fibrosis in ALL pediatric cases at the time of diagnosis. Nevertheless, fibrosis does not affect survival.

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Post-chemotherapy Changes in Bone Marrow in Acute Leukemia With Emphasis on Detection of Residual Disease by Immunohistochemistry

Abstract: In acute leukemia, the leading cause of treatment failure is disease relapse leading to a low level of complete remission and short overall survival. Post-chemotherapy marrow examination gives vital clues regarding treatment response and marrow regeneration.

Cited by 2 publications

References 19 publications

Comparison of Multiparameter Flow Cytometry and ClonoSEQ Studies for Precursor B-Lymphoblastic Leukemia Minimal Residual Disease Detection on Bone Marrow Samples

Comparison of Multiparameter Flow Cytometry and ClonoSEQ Studies for Precursor B-Lymphoblastic Leukemia Minimal Residual Disease Detection on Bone Marrow Samples

The relationship of bone marrow fibrosis at diagnosis with prognosis and survival in childhood acute lymphoblastic leukemia

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