In effectively resuscitated out-of-hospital cardiac arrest (OHCA) patients who progress to brain death (BD), resuscitated OHCA with predominantly nonshockable initial rhythms was independently associated with the following five risk factors associated with progression toward BD: female gender, young age, neurologic cause of cardiac arrest, duration of low-flow period, and persistent hemodynamic shock, all of which were independently associated with BD. We require employment of neuroprotection methods to those cases suffering from OHCA, or even from intrahospital cardiac arrests, based on the examination of prognostic risk factors.