Post-burn hypertrophic scars are characterized by high levels of IL-1β mRNA and protein and TNF-α type I receptors

Salgado, Rosa M.; Alcántara, Luz; Mendoza-Rodríguez, C. Adriana; Cerbón, Marco; Hidalgo-González, Christian; Mercadillo, Patricia; Moreno, Luis Moral; Álvarez-Jiménez, Ricardo; Krötzsch, Edgar

doi:10.1016/j.burns.2011.12.012

Cited by 31 publications

(23 citation statements)

References 33 publications

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“…73,83,91,92 A number of investigations have found that mechanical force on wounds, particularly cyclical force, stimulates the release of growth factors such as TGF-β. 56,93–97 The upregulation of these factors and their receptors is associated with keloid and hypertrophic scar formation. 97–100 These studies suggest that although mechanical force has the potential to accelerate tensile strength gain, the trade-off may be an increase in abnormal scarring.…”

Section: Mechanical Stress and Scarringmentioning

confidence: 99%

The Role of Wound Healing and Its Everyday Application in Plastic Surgery

Ireton

Unger

Rohrich

2013

Plastic and Reconstructive Surgery Global Open

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Background:After surgery it is often recommended that patients should refrain from strenuous physical activity for 4–6 weeks. This recommendation is based on the time course of wound healing. Here, we present an overview of incisional wound healing with a focus on 2 principles that guide our postoperative recommendations: the gain of tensile strength of a wound over time and the effect of mechanical stress on wound healing.Methods:A systematic search of the English literature was conducted using OVID, Cochrane databases, and PubMed. Inclusion criteria consisted of articles discussing the dynamics of incisional wound healing, and exclusion criteria consisted of articles discussing nonincisional wounds.Results:Experiments as early as 1929 laid the groundwork for our postoperative activity recommendations. Research using animal models has shown that the gain in tensile strength of a surgical wound is sigmoidal in trajectory, reaching maximal strength approximately 6 weeks postoperatively. Although human and clinical data are limited, the principles gained from laboratory investigation have provided important insights into the relationship among mechanical stress, collagen dynamics, and the time course of wound healing.Conclusion:Our postoperative activity recommendations are based on a series of animal studies. Clinical research supporting these recommendations is minimal, with the most relevant clinical data stemming from early motion protocols in the orthopedic literature. We must seek to establish clinical data to support our postoperative activity recommendations so that we can maximize the physiologic relationships between wound healing and mechanical stress.

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Section: Mechanical Stress and Scarringmentioning

confidence: 99%

The Role of Wound Healing and Its Everyday Application in Plastic Surgery

Ireton

Unger

Rohrich

2013

Plastic and Reconstructive Surgery Global Open

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“…Thus, the technique needs to be modified to modulate the wound healing process. An aberrant inflammatory process during wound healing contributes to a hypertrophic scar through release of fibrogenic cytokines, such as transforming growth factor‐β1 and interleukin‐1 . Angiogenesis also occurs and participates in feeding scar tissue, which eventually results in a hypertrophic scar .…”

mentioning

confidence: 99%

“…An aberrant inflammatory process during wound healing contributes to a hypertrophic scar through release of fibrogenic cytokines, such as transforming growth factor-b1 and interleukin-1. [6][7][8] Angiogenesis also occurs and participates in feeding scar tissue, which eventually results in a hypertrophic scar. [9][10][11] Thus, we hypothesized that scar formation at a thyroidectomy site could be prevented by inhibiting the inflammatory process and that angiogenesis could be mediated using intralesional steroid injection and dye laser treatment.…”

mentioning

confidence: 99%

Prevention of Thyroidectomy Scars in Korean Patients Using a New Combination of Intralesional Injection of Low-Dose Steroid and Pulsed Dye Laser Starting within 4 Weeks of Suture Removal

Ryu

Cho

Lee

et al. 2014

Dermatologic Surgery

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“…All of these disorders will lead to gradual glomerular injury. Numerous studies have provided evidence that burns upregulate inflammatory cytokines such as TNF-α and IL-1β [9]. Those cytokines can interfere with the hemodynamics of intraglomerular microcirculation, the coagulation-fibrinolysis system and the infiltration of inflammatory cells after burns.…”

Section: Discussionmentioning

confidence: 99%

IgA Nephropathy with Pathologic Features of Membranoproliferative Glomerulonephritis following Burn Injury

Zhu

Wang

Yang

2014

Case Rep Nephrol Dial

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IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, accounting for approximately 30-40% of patients undergoing renal biopsy in Asia. The characteristic and diagnostic lesion of IgAN is the deposition of glomerular IgA. The morphological lesions observed by light microscopy are extremely variable. A causal relationship between IgAN and burn injury has not been established, and the correlation between them is not clear if they appear at the same time. We have explored the cause of severe proteinuria of a Chinese patient with burns of 2nd or 3rd degree after a gas leakage accident 2 weeks ago. The diffuse proliferative glomerulonephritis of this patient revealed type I membranoproliferative glomerulonephritis-like symptoms. Moreover, this patient showed a sensitive response to prednisone. This case report demonstrates the intrinsic relationship between kidney disease and burn injury, which will facilitate a feasible treatment strategy for proteinuria after burn injury.

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Post-burn hypertrophic scars are characterized by high levels of IL-1β mRNA and protein and TNF-α type I receptors

Cited by 31 publications

References 33 publications

The Role of Wound Healing and Its Everyday Application in Plastic Surgery

The Role of Wound Healing and Its Everyday Application in Plastic Surgery

Prevention of Thyroidectomy Scars in Korean Patients Using a New Combination of Intralesional Injection of Low-Dose Steroid and Pulsed Dye Laser Starting within 4 Weeks of Suture Removal

IgA Nephropathy with Pathologic Features of Membranoproliferative Glomerulonephritis following Burn Injury

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