Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT

Mineo, Giangaspare; Ciccarese, Federica; Modolon, Cecilia; Landini, M.P.; Valentino, Massimo; Zompatori, Maurizio

doi:10.1007/s11547-011-0740-3

Cited by 67 publications

(71 citation statements)

References 27 publications

(38 reference statements)

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“…The signs of fibrosis (including parenchymal bands, irregular linear opacities, interfaces and traction bronchiectasis) in most of our patients were gradually regressed with time [1]. Other researchers also reported that pulmonary fibrosis in patients with H1N1 pneumonia was not a rare complication and could partially regress over time [2,3]. A few of our patients with influenza A (H1N1) virus infection responded quickly to the corticosteroids.…”

supporting

confidence: 57%

Response to the letter to the editor: Organising pneumonia as a late abnormality in influenza A (H1N1) virus infection

Li¹,

Bl²,

Zhang³

et al. 2012

BJR

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supporting

confidence: 57%

Response to the letter to the editor: Organising pneumonia as a late abnormality in influenza A (H1N1) virus infection

Li¹,

Bl²,

Zhang³

et al. 2012

BJR

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“…This finding is not completely specific because the reversibility of bronchial dilatation has also been described in the late stages of ARDS [60,61].…”

Section: Acute Respiratory Distress Syndrome | M Zompatori Et Almentioning

confidence: 89%

Overview of current lung imaging in acute respiratory distress syndrome

2014

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Imaging plays a key role in the diagnosis and follow-up of acute respiratory distress syndrome (ARDS). Chest radiography, bedside lung ultrasonography and computed tomography scans can provide useful information for the management of patients and detection of prognostic factors. However, imaging findings are not specific and several possible differential diagnoses should be taken into account. Herein we will review the role of radiological techniques in ARDS, highlight the plain radiological and computed tomography findings according to the pathological stage of the disease (exudative, inflammatory and fibroproliferative), and summarise the main points for the differential diagnosis with cardiogenic oedema, which is still challenging in the acute stage. @ERSpublications ARDS diagnosis is still based on radiological criteria; the variety of these findings should be known and recognised

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“…These results would need to be interpreted in light of the patient’s history and clinical course. For example, mechanical ventilation parameters [16, 17] and specific risk factors underlying ARDS development [69] have been associated with a more protracted clinical course and subsequent fibrotic lung disease.…”

Section: Identification Of Excessive Fibroproliferation May Help Guidmentioning

confidence: 99%

“…A separate group has confirmed the utility of HRCT obtained during the acute phase of pathologically confirmed diffuse alveolar damage, and found that increased radiological lung involvement, as well as traction bronchiectasis, were associated with death [80]. Finally, published studies of the 2009 H1N1 epidemic indicate that HRCT is similarly useful in predicting mortality and long-term morbidity in patients with ARDS from influenza A [69, 81]. Our group’s recent observations complement and add to these investigations and suggest that HRCT performed early in the course of ARDS may prognosticate functional impairment in survivors months after discharge [18].…”

Section: Identification Of Excessive Fibroproliferation May Help Guidmentioning

confidence: 99%

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

Burnham

Janssen

Riches

et al. 2013

European Respiratory Journal

287

274

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Acute respiratory distress syndrome (ARDS) continues to be a major healthcare problem, affecting >190 000 people in the USA annually, with a mortality of 27–45%, depending on the severity of the illness and comorbidities. Despite advances in clinical care, particularly lung protective strategies of mechanical ventilation, most survivors experience impaired health-related quality of life for years after the acute illness. While most patients survive the acute illness, a subset of ARDS survivors develops a fibroproliferative response characterised by fibroblast accumulation and deposition of collagen and other extracellular matrix components in the lung. Historically, the development of severe fibroproliferative lung disease has been associated with a poor prognosis with high mortality and/or prolonged ventilator dependence. More recent studies also support a relationship between the magnitude of the fibroproliferative response and long-term health-related quality of life. The factors that determine which patients develop fibroproliferative ARDS and the cellular mechanisms responsible for this pathological response are not well understood. This article reviews our current understanding of the contribution of pulmonary dysfunction to mortality and to quality of life in survivors of ARDS, the mechanisms driving pathological fibroproliferation and potential therapeutic approaches to prevent or attenuate fibroproliferative lung disease.

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Post-ARDS pulmonary fibrosis in patients with H1N1 pneumonia: role of follow-up CT

Cited by 67 publications

References 27 publications

Response to the letter to the editor: Organising pneumonia as a late abnormality in influenza A (H1N1) virus infection

Response to the letter to the editor: Organising pneumonia as a late abnormality in influenza A (H1N1) virus infection

Overview of current lung imaging in acute respiratory distress syndrome

The fibroproliferative response in acute respiratory distress syndrome: mechanisms and clinical significance

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