Post-acute sequelae of SARS-CoV-2 (PASC) impact quality of life at 6, 12 and 18 months post-infection

Demko, Zoe O; Yu, Tong; Mullapudi, Sarika K.; Heslin, M. Gabriela Varela; Dorsey, Chamia A.; Payton, Christine; Tornheim, Jeffrey A.; Blair, Paul W; Mehta, Shruti H.; Thomas, David L.; Manabe, Yukari C.; Antar, Annukka A.R.

doi:10.1101/2022.08.08.22278543

Cited by 20 publications

(15 citation statements)

References 12 publications

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“…2). Symptoms can last for years 13 , and particularly in cases of new-onset ME/CFS and dysautonomia are expected to be lifelong 14 . With significant proportions of individuals with long COVID unable to return to work 7 , the scale of newly disabled individuals is contributing to labour shortages 15 .…”

Section: Introductionmentioning

confidence: 99%

Long COVID: major findings, mechanisms and recommendations

Davis¹,

McCorkell²,

et al. 2023

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Long COVID is an often debilitating illness that occurs in at least 10% of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections. More than 200 symptoms have been identified with impacts on multiple organ systems. At least 65 million individuals worldwide are estimated to have long COVID, with cases increasing daily. Biomedical research has made substantial progress in identifying various pathophysiological changes and risk factors and in characterizing the illness; further, similarities with other viral-onset illnesses such as myalgic encephalomyelitis/chronic fatigue syndrome and postural orthostatic tachycardia syndrome have laid the groundwork for research in the field. In this Review, we explore the current literature and highlight key findings, the overlap with other conditions, the variable onset of symptoms, long COVID in children and the impact of vaccinations. Although these key findings are critical to understanding long COVID, current diagnostic and treatment options are insufficient, and clinical trials must be prioritized that address leading hypotheses. Additionally, to strengthen long COVID research, future studies must account for biases and SARS-CoV-2 testing issues, build on viral-onset research, be inclusive of marginalized populations and meaningfully engage patients throughout the research process.

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Section: Introductionmentioning

confidence: 99%

Long COVID: major findings, mechanisms and recommendations

Davis¹,

McCorkell²,

et al. 2023

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“…These include female sex, older and middle age, lower socioeconomic status and access to healthcare, and the presence of certain comorbid medical conditions including diabetes and obesity. Preexisting anxiety and depressive symptoms have also been associated with the development of Long COVID in some but not all studies [46,47] and mood symptoms may cooccur with physical symptoms in some individuals experiencing this condition.…”

Section: Epidemiology and Natural History Of Long Covidmentioning

confidence: 99%

Long COVID in people living with HIV

Peluso

Antar

2023

Current Opinion in HIV and AIDS

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Purpose of reviewIt is now recognized that SARS-CoV-2 infection can have a long-term impact on health. This review summarizes the current state of knowledge regarding Long COVID in people living with HIV (PLWH). Recent findingsPLWH may be at elevated risk of experiencing Long COVID. Although the mechanisms contributing to Long COVID are incompletely understood, there are several demographic and clinical factors that might make PLWH vulnerable to developing Long COVID. SummaryPLWH should be aware that new or worsening symptoms following SARS-CoV-2 infection might represent Long COVID. HIV providers should be aware of this clinical entity and be mindful that their patients recovering from SARS-CoV-2 infection may be at higher risk.

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“…While most patients with COVID-19 recover fully, some individuals experience persistent symptoms after the acute phase of the infection, known as long COVID-19. Long COVID-19 is an umbrella term for symptoms that continue for at least 4 weeks following the initial onset of COVID-19 [ 14 , 15 ] and can last for years [ 16 ]. Globally, 43% of individuals who have had COVID-19 report experiencing some degree of long COVID-19 symptoms [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of long COVID-19 on posttraumatic stress disorder as modified by health literacy: an observational study in Vietnam

Vo,

Dao,

Duong

et al. 2024

PHRP

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Objectives: The incidence of posttraumatic stress disorder (PTSD) has increased, particularly among individuals who have recovered from coronavirus disease 2019 (COVID-19) infection. Health literacy is considered a “social vaccine” that helps people respond effectively to the pandemic. We aimed to investigate the association between long COVID-19 and PTSD, and to examine the modifying role of health literacy in this association.Methods: A cross-sectional study was conducted at 18 hospitals and health centers in Vietnam from December 2021 to October 2022. We recruited 4,463 individuals who had recovered from COVID-19 infection for at least 4 weeks. Participants provided information about their sociodemographics, clinical parameters, health-related behaviors, health literacy (using the 12-item short-form health literacy scale), long COVID-19 symptoms and PTSD (Impact Event Scale-Revised score of 33 or higher). Logistic regression models were used to examine associations and interactions.Results: Out of the study sample, 55.9% had long COVID-19 symptoms, and 49.6% had PTSD. Individuals with long COVID-19 symptoms had a higher likelihood of PTSD (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.63–2.12; p<0.001). Higher health literacy was associated with a lower likelihood of PTSD (OR, 0.98; 95% CI, 0.97–0.99; p=0.001). Compared to those with long COVID-19 symptoms and the lowest health literacy score, those with long COVID-19 symptoms and a 1-point health literacy increment had a 3% lower likelihood of PTSD (OR, 0.97; 95% CI, 0.96–0.99; p=0.001).Conclusion: Health literacy was found to be a protective factor against PTSD and modified the negative impact of long COVID-19 symptoms on PTSD.

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Post-acute sequelae of SARS-CoV-2 (PASC) impact quality of life at 6, 12 and 18 months post-infection

Cited by 20 publications

References 12 publications

Long COVID: major findings, mechanisms and recommendations

Long COVID: major findings, mechanisms and recommendations

Long COVID in people living with HIV

Impact of long COVID-19 on posttraumatic stress disorder as modified by health literacy: an observational study in Vietnam

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