Possible virulence factors of Staphylococcus sciuri

Abstract

Staphylococcus sciuri is an opportunistic pathogen of controversial clinical significance. The factors that contribute to colonization and/or infection caused by this bacterium have not been studied intensively so far. The present research was carried out in order to study the presence of potential virulence factors in 121 human and animal isolates of this bacterium. Isolates were examined for biofilm formation, hemagglutination, presence of clumping factor, production of spreading factors and exotoxins, cytotoxicity and capacity to stimulate nitric oxide production. The results showed that S. sciuri is highly capable of biofilm production, that it displays strong proteolytic and DNase activities, produces hemolysins and stimulates nitric oxide production by rat macrophages. Although the present study showed existence of a wide spectrum of possible virulence determinants of S. sciuri, their exact contribution to virulence of this bacterium in vivo remains to be determined.

Mossambicus tilapia (Oreochromis mossambicus) collected from water bodies impacted by urban waste carries extended-spectrum beta-lactamases and integron-bearing gut bacteria

“…from Tilapia gut. Emerging opportunistic human pathogens such as Leclercia adecarboxylata and Staphylococcus sciuri were also detected (Brenden et al 1988;Stepanović et al 2001;Stock et al 2004). Fish pathogen, Plesiomonas shigelloides is known to cause gastroenteritis and sometimes other infections in humans (Brenden et al 1988).…”

Staphylococcus sciuri Exfoliative Toxin C (ExhC) is a Necrosis-Inducer for Mammalian Cells

“…S. sciuri is widely distributed in nature, and strains can be easily isolated from a variety of animals and products of animal origin [24], [25] as well as from humans [26], [27]. These bacteria are normally nonpathogenic, but occasionally cause diseases in animals and humans [1]–[7].…”

A Highly Pathogenic Strain of Staphylococcus sciuri Caused Fatal Exudative Epidermitis in Piglets

“…Members of the S. sciuri group are widely distributed in nature, and they can be isolated from a variety of animals and the products of animal origin [19]–[21] as well as from human [22], [23], but most of them are apathogenic to animals. However they are important human pathogens responsible for?endocarditis [24], peritonitis [25], septic shock [26], urinary tract infection [27], pelvic inflammatory disease [28] and wound infections [29], [30].…”