Possible Utilization of Polyelectrolytes in Enhancing Drug Absorption

Higuchi, Takeru; Kuramoto, Roy; Kennon, Lloyd; Flanagan, Thomas L.; Polk, Andrew

doi:10.1002/jps.3030431104

Cited by 11 publications

(3 citation statements)

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“…Statistical analysis shows significant differences ( p < 0.01) between each drug solution flux and the other one. Previous reports (8,18) have demonstrated the influence of some macromolecular excipients on drug dissolution, dialysis, and absorption; for example, Higuchi et al (8) reported that sodium carboxymethylcellulose and sodium polyacrylate enhanced the dialysis rate of sodium salicylate and potassium benzylpenicillinate through cellophane. Wurster and Taylor (18) reported that an increase in viscosity results in a decrease in the rate of dissolution and absorption of a drug molecule.…”

Section: Resultsmentioning

confidence: 99%

“…First, the ultraviolet spectra of drug in the presence and absence of the macromolecules were obtained and compared with each other. If the complex between drug and polymer molecule was formed, the UV spectrum of the solution would be changed (8,25). The UV spectra of furosemide in the present and absence of each NaAlg and NaCMC showed no difference between them, so it seems that there was no complex formation between furosemide and these macromolecules.…”

Section: Resultsmentioning

confidence: 99%

“…In dialysis studies, the experimental procedure previously employed for other studies on the binding effects of macromolecular substances on drugs was used (8,13,14). The method consisted of bringing two solutions, one containing the macromolecular component and the other the drug under study, into equilibrium across a semipermeable membrane.…”

Section: Equilibrium Dialysis Proceduresmentioning

confidence: 99%

See 2 more Smart Citations

Investigation of Furosemide Dialysis Rate in the Presence of Anionic Polymers

Zakei-Milani¹,

Islambolchilar²,

Ebrahimpoor³

et al. 2012

Dissolution Technol.

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The aim of the present study was to determine the in vitro dialysis of furosemide, an anionic drug, in the presence of anionic macromolecules. The polymers (sodium carboxymethylcellulose, sodium alginate, and methylcellulose) were used at different concentrations, and the drug concentration in the dialysis bag was 250 µg/mL. The entire process was performed in a receptor chamber in which a dialysis bag was placed as a donor medium. The samples were collected at different times up to 4 h at 37 °C. Finally, the samples were analyzed by UV spectrophotometry at 277.5 nm. Methylcellulose was used as a neutral macromolecule to show the influence of polymer viscosity in the dialysis process. The dialysis rate increased with increasing macromolecule concentration up to a certain limit. This effect could be explained by Donnan equilibrium. Polyelectrolytes (e.g., sodium alginate and sodium carboxymethylcellulose) enhance the transport rate of ionic drugs with the same electrical charge. However, the increased medium viscosity in the dialysis process limits the Donnan effect. It is concluded that anionic macromolecules in specific concentrations could be used as transport-enhancer excipients for anionic drugs such as furosemide.

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