Possible Utility of the Rous Sarcoma for Antitumor Screening

Johnson, Irving S.; Baker, Linville A.; Wright, Howard F.

doi:10.1111/j.1749-6632.1958.tb54904.x

Cited by 14 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports from other laboratories have shown (Johnson et al, 1958;Pienta et al, 1963) that virus-induced Rous sarcoma provides an effective test system for evaluation of possible therapeutic preparations. This system also provides a model for study of the host-tumor relationship, with a balance very much against the young host.…”

mentioning

confidence: 99%

Effect of reticuloendothelial system stimulation on resistance to rous sarcoma virus infection in chicks

Bliznakov

1968

Intl Journal of Cancer

View full text Add to dashboard Cite

By using a non‐toxic reticuloendothelial system stimulant, lipid‐Restim, derived from shark livers, we were able to demonstrate the following effects on growing Rous sarcoma tumors in young chicks. Prechallenge Restim treatment: Significant reduction of the percentage of chicks with tumors and prolongation of the latent period resulted from combined administration of Restim and specific antiserum. Postchallenge Restim treatment: The mortality data indicated that there was a significant increase in survival time and survival rate. Complete regressions occurred in a significant number of the Restim‐treated chicks compared to the controls. Possible explanations of these findings are discussed.

show abstract

mentioning

confidence: 99%

Effect of reticuloendothelial system stimulation on resistance to rous sarcoma virus infection in chicks

Bliznakov

1968

Intl Journal of Cancer

View full text Add to dashboard Cite

show abstract

Studies and observations on the growth of mammalian cells in agitated fluid medium

Cherry

Hull

1960

Biotechnol. Bioeng.

View full text Add to dashboard Cite

Summary. Fourteen mammalian cell strains were studied in the 'stirrer culture'. Fair to excellent growth wm obtained with twelve of these strains while two strains failed to show evidence of proliferation. Growth curves, maximal population densities, and recovery following subculture of various cell strains, cultivated in this system, were described. Factors effecting the growth of cells under these conditions were outlined. Growth of cells in methods other than the 'stirrer culture' were reported. The practical importance of fluid suspension culture of mammalian cells, the potentialities and the problems involved in scaling such cultures to industrial size were discussed.

show abstract

Some Antineoplastic Antibiotics

Cheng

Zee-Cheng

1972

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Possible Utility of the Rous Sarcoma for Antitumor Screening

Cited by 14 publications

References 0 publications

Effect of reticuloendothelial system stimulation on resistance to rous sarcoma virus infection in chicks

Effect of reticuloendothelial system stimulation on resistance to rous sarcoma virus infection in chicks

Studies and observations on the growth of mammalian cells in agitated fluid medium

Some Antineoplastic Antibiotics

Contact Info

Product

Resources

About