Possible toxicity following embolization of congenital giant vertex hemangioma: case report

Kieran, Ingrid; Zakaria, Zaitun; Kaliaperumal, Chandrasekaran; O’Rourke, Declan; O’Hare, Alan; Laffan, Eoghan; Caird, John; King, Mary D.; Murray, Dylan J.

doi:10.3171/2016.5.peds13345

Cited by 10 publications

(4 citation statements)

References 6 publications

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“…We speculate that the embolic agent may induce the formation of microthrombi in the spinal cord, thereby increasing the risk of LD in EVT patients. Embolic agents have been shown to have toxic effects on nervous tissue ( 24 – 26 ). Therefore, it is speculated that the toxic effects of embolic agents on the delicate spinal cord may be another important reason why EVT patients are more susceptible to LD.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for postoperative late deterioration in patients with spinal dural arteriovenous fistulas

Ge,

Lai,

Guo

et al. 2024

Front. Neurol.

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BackgroundApproximately 86% of patients with spinal dural arteriovenous fistulas (SDVAFs) exhibit clinical improvement after surgery. However, 12%-55.8% of these patients experience late deterioration (LD) after an initial period of improvement. The risk factors for LD remain unclear. The aim of this study was to explore the risk factors for LD in SDVAF patients.MethodsThe clinical data of patients who were admitted to two tertiary hospitals between June 2014 and May 2022 were reviewed. Patients were divided into two groups: the LD group and the no LD group. The severity of neurological dysfunction (NDF) was evaluated using the Modified Aminoff and Logue Scale. Univariable and multivariable Cox regression analyses were performed.ResultsA total of 105 eligible patients were enrolled, with a mean age of 57.55 ± 9.42 years. The LD group comprised 37 individuals, while the no LD group consisted of 68 individuals. According to the univariable analysis, preoperative NDF severity and treatment strategy were associated with the risk of LD. According to the multivariable analysis, patients who underwent microsurgery (MS) had a lower risk of LD than did those who underwent endovascular treatment (EVT; HR 0.197, 95% CI 0.085-0.457), and patients with severe NDF had a higher risk of LD than did those with mild NDF (HR 3.604, 95% CI 1.226-10.588), whereas the risk of LD in patients with moderate NDF was similar to that of patients with mild NDF (HR 1.352, 95% CI 0.519-3.524).ConclusionEVT and severe preoperative NDF are independent risk factors for LD.

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Section: Discussionmentioning

confidence: 99%

Risk factors for postoperative late deterioration in patients with spinal dural arteriovenous fistulas

Ge,

Lai,

Guo

et al. 2024

Front. Neurol.

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“…Propranolol, vincristine and corticosteroids have been utilized with limited effectiveness 29 . Embolization is usually utilized as an additional bleeding control method 31,32 . Surgical excision is the only treatment method that has been demonstrated to be de nitive 33,34 .…”

Section: Discussionmentioning

confidence: 99%

Novel organoid construction strategy for non-involuting congenital hemangioma for drug validation

Wei

et al. 2023

Preprint

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Background:Non-involuting congenital hemangiomas (NICHs) are fully formed vascular tumors at birth, with distinctive clinical, radiologic, and histopathological profiles. In the literature, there is no effective therapy strategy for patients with NICH except surgery. Currently, no cell line or animal model exists for studying the mechanism of NICH and drug validation. We plan to construct a new strategy by constructing NICH organoids for further study. Result:Here, we report a novel NICH organoid system construction and optimizationprocess. Both HE and immunohistological staining exactly matched NICH tissue. We further performed transcriptome analysis to elucidate the characteristics of NICH organoids. Both NICH tissue and NICH organoids manifested similar trends in download sites. NICH organoids display novel features to new cells derived from organoids and show spectacular multiplication capacity. In the preliminary verification, we found that cells splitting from NICH organoidswere human endothelial cells. Drug validation demonstrated that trametinib, sirolimus, and propranolol showed no inhibitory effects on NICH organoids. Conclusion: Our data show that this new NICH-derived organoid faithfully captured the features of this rare vascular tumor. Our study will boost further research on the mechanism of NICH and drug filtering in the future.

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“…Other scholars found that glue can cause neuronal necrosis, nerve fiber rupture and demyelination, and lead to T lymphocytes, mast cells and macrophages infiltration. It suggests that the application of medical glue to nervous tissue or other sensitive tissues must be carefully selected [17, 18]. In our early study, most patients did not have adverse reactions although medical glue was not completely removed from deep orbital lesions.…”

Section: Discussionmentioning

confidence: 99%

Clinical outcome observation of the embolization of orbital vascular malformation with medical glue under direct intra-operative view

Lin

Zhu

2018

BMC Ophthalmol

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BackgroundOrbital vascular malformation often encircles normal tissue with ill-defined borders. It is easy to bleed during resection operation, making surgical treatment difficult and lesions hard to be removed completely. In this study we aimed to summarize the treatment outcomes by embolizing orbital vascular malformation with intraoperative intracavitary injection of medical glue .MethodsA retrospective observational and cross-sectional case series study enrolled 31 patients (male = 9, female = 22) with orbital vascular malformations, who were treated from March 2008 to September 2017 at our institution. The clinical features, operation records, pathological reports and follow-up data were analyzed.ResultsThe location of vascular malformations involved intraorbital (14 cases), superficial area of eyelid and/or face (7 cases), both intraorbital and superficial area (10 cases). Imaging examination showed a solitary mass with regular shape in 8 cases and a space occupying lesion with irregular shape and ill-defined margins in 23 cases. There were 9 cases had optic nerve involved. Surgical debulkling were performed via skin incision on the mass surface (5 cases), lateral orbitotomy (2 cases), and anterior orbitotomy (24 cases). During the operation, lesions were partly exposed and injected with medical glue. The amount of injected glue was 0.25 ml to 2.5 ml in divided doses. The lesions and remnant glue were removed after the glue had turned hard. The whole procedure caused less bleeding and was easier performing than usual. Topical skin aseptic inflammation took place on the same side of the superficial eyelid lesions in 3 cases. One patient suffered from sudden central retinal artery embolism on the third day post operation. With timely rescue and appropriate procedure, visual acuity recovered to 20/32. There were no recurrences in 29 cases.ConclusionsEmbolization of orbital vascular malformation with medical glue intraoperatively made it easy to control hemorrhage. Surgeons should be careful with glue application methods in order to avoid complications.

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Possible toxicity following embolization of congenital giant vertex hemangioma: case report

Cited by 10 publications

References 6 publications

Risk factors for postoperative late deterioration in patients with spinal dural arteriovenous fistulas

Risk factors for postoperative late deterioration in patients with spinal dural arteriovenous fistulas

Novel organoid construction strategy for non-involuting congenital hemangioma for drug validation

Clinical outcome observation of the embolization of orbital vascular malformation with medical glue under direct intra-operative view

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