Possible Synapse Formation by Embryonic Cerebellar Tissue Grafted into the Cerebellum of the Weaver Mutant Mouse

Takayama, Hideichi; Toya, Shigeo; Shinozaki, Tamotsu; Inoué, Hiroshi; Otani, Mitsuhiro; Kohsaka, Sh.; Tsukada, Yasuzo

doi:10.1007/978-3-7091-8978-8_33

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…They suffer from disorganization of granule layer development and degeneration of cerebellar granule cells [ 62 , 63 ]. In Weaver mice, dissociated embryonic cerebellar cells grafted onto the cerebellum developed into a large mass of tissue with a trilaminar organization [ 64 – 66 ]. Grafted granule-like cells proliferated, migrated from the place of transplantation and were able to develop synaptic contacts in the Weaver mutant cerebellum [ 64 – 66 ].…”

Section: Neurotransplantation In Cerebellar Mutant Micementioning

confidence: 99%

Experimental neurotransplantation treatment for hereditary cerebellar ataxias

Cendelín

2016

cerebellum ataxias

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Hereditary cerebellar degenerations are a heterogeneous group of diseases often having a detrimental impact on patients’ quality of life. Unfortunately, no sufficiently effective causal therapy is available for human patients at present. There are several therapies that have been shown to affect the pathogenetic process and thereby to delay the progress of the disease in mouse models of cerebellar ataxias. The second experimental therapeutic approach for hereditary cerebellar ataxias is neurotransplantation. Grafted cells might provide an effect via delivery of a scarce neurotransmitter, substitution of lost cells if functionally integrated and rescue or trophic support of degenerating cells. The results of cerebellar transplantation research over the past 30 years are reviewed here and potential benefits and limitations of neurotransplantation therapy are discussed.

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