Possible Susceptibility of the HLA‐DPB1*0402 and HLA‐DPB1*04 Alleles to Unexplained Recurrent Abortion: Analysis by means of Polymerase Chain Reaction–Restricted Fragment Length Polymorphism Method

Takakuwa, Koichi; Hataya, Isao; Arakawa, Masato; Kikuchi, Akira; Higashino, Masahiko; Yasuda, Masako; Kurabayashi, Takumi; Tanaka, Kenichi

doi:10.1111/j.1600-0897.1999.tb00096.x

Cited by 16 publications

(10 citation statements)

References 28 publications

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“…[1] Further among the UK RSA patient population linkage disequilibrium between A2 and B12 has been reported. [2] Various studies on HLA DR and DP loci have shown associations with RSA in Italian,[10] Danish,[69] and Japanese[578] populations. Recently, HLA DRB1*1502 has been reported to be significantly associated in Japanese RSA patients.…”

Section: Discussionmentioning

confidence: 99%

HLA allele associations in idiopathic recurrent spontaneous abortion patients from India

Shankarkumar¹,

Pawar²,

Gaonkar³

et al. 2008

J Hum Reprod Sci

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BACKGROUND:Rejection of semiallogenic foetus in recurrent spontaneous abortion (RSA) has been postulated to be a consequence of genetic and immunological phenomena.AIM:To evaluate the role of human leukocyte antigen (HLA) alleles in RSA in Indian couples.SETTINGS AND DESIGN:A case-control study.MATERIALS AND METHODS:Eighty-one randomly selected couples with unexplained three or more RSAs and a control group of 97 couples with live birth belonging to the same ethnic background, referred to the Gynaecology Department, KEM Hospital were included in the case-control study. Serological HLA A and B typing was done followed by molecular subtypes, defined using PCR-SSOP technique for HLA A, B, and C in 40 couples and DRB1* and DQB1* in 28 couples which were then compared with appropriate case 46 and 88 controls.RESULTS:Serologically A3 (15.43% vs. 4.43%; odds ratio (OR) = 4.34; P = 0.0002) and B17 (25.3% vs. 11.34%; OR = 3.49; P = 0.0001) were increased. Haplotype A1-B17 was significantly increased. Molecular subtyping revealed that A*030102 (11.25% vs. 4.34%; OR = 3.00; P = 0.07), B*5701 (11.25% vs. 1.08%; OR = 13.10; P = 0.003), Cw*120201 (25% vs. 4.34%; OR = 10.50; P = 2.05E-05), HLA DRB1*030101 (17.85% vs. 3.40%; OR = 7.6; P = 0.0001), DRB1*150101 (32.14% vs. 13.63%; OR = 4.8; P = 0.0003), and DQB1*060101 (35.71% vs. 29.34%; OR = 2.3; P = 0.004) were significantly increased in patients. A differential association was noticed when compared with reported world RSA patients.CONCLUSION:The HLA alleles A*030101, B*5701, Cw*120201, DRB1*030101, and DRB1*150101 as well as their associated ancestral haplotype may play a significant role in development of RSA in India.

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Section: Discussionmentioning

confidence: 99%

HLA allele associations in idiopathic recurrent spontaneous abortion patients from India

Shankarkumar¹,

Pawar²,

Gaonkar³

et al. 2008

J Hum Reprod Sci

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“…An earlier study on Japanese women documented the positive link between HLA-DPB1*0402 and HLA-DPB1*04 alleles with an increased risk of RPL. 31 This was contradictory to our recent findings on Lebanese women in which DPB1*04:01:01 and DPB1*14:01:01 (and DRB1*07:01:01) were negatively associated with RPL and thus are presumably "RPL-protective 5 ." While these and other findings confirmed a role for the HLA system in the pathogenesis of RPL, they also highlighted the contribution of ethnic/racial background in determining the nature of HLA allele and haplotype associated with altered disease risk, 20,32 including that of RPL.…”

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confidence: 57%

Maternal HLA class II alleles and haplotypes associated with altered risk of recurrent pregnancy loss: A case‐control study

Aimagambetova,

Kapasheva,

Bahia

et al. 2024

American J Rep Immunol

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ProblemThis study analyzed the contribution of DRB1, DQB1, and DPB1 HLA class II alleles and resulting 3‐locus haplotypes to the overall risk of idiopathic recurrent pregnancy loss (RPL).Method of studyThe study participants included 188 Tunisian participants comprising 84 women with established diagnoses of RPL, and 104 matched multiparous females as controls. Genotyping of HLA alleles was done by PCR‐SSP.ResultsThe allelic frequencies of DPB1, DRB1, and DQB1 were consistent with Hardy‐Weinberg equilibrium among control subjects. Among class II alleles, DRB1*04:01:01 (p = .03), DRB1*08:01:01 (p = .04), and DPB1*01:01:01 (p = .04) were positively associated, whereas DPB1*04:01:01 (p = .012) and DPB1*14:01:01 (p = .006) were negatively associated with risk of RPL. The association of DRB1 and DPB1 alleles with RPL was lost after correction for multiple comparisons. The prevalence of the seven determined DQB1 alleles was not significantly different among case and control groups. Higher prevalence of DRB1*07:01:01∼ DQB1*02:01:01∼DPB1*04:01:01 (0.0417 vs. 0.000; p = .049) coupled with lower prevalence of DRB1*13:01:01∼DQB1*06:01:01∼DPB1*02:01:01 (0.0167 vs. 0.1000; p = .014) haplotypes was noted in women with RPL, thus could be considered as an RPL at‐risk and RPL‐protective haplotype, respectively.ConclusionThe study establishes weak/no contribution of class II alleles and corresponding 3‐locus haplotypes to the altered risk of RPL among Tunisian women and does not confirm previous findings on other Arab‐speaking populations of an HLA association with RPL.

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“…Christiansen et al reported that maternal HLA DR1, DR3, and DR10 were genetic markers for pregnancy loss in Danish recurrent spontaneous abortion patients and their relatives [6]. Our group reported that the frequency of HLA-DPB1*0402 and -DPB1*04 in a patient group with unexplained recurrent abortion was significantly higher compared with healthy fertile women and with the general population [29]. Our group reported that the frequency of HLA-DPB1*0402 and -DPB1*04 in a patient group with unexplained recurrent abortion was significantly higher compared with healthy fertile women and with the general population [29].…”

Section: Discussionmentioning

confidence: 53%

HLA-class I antigens in patients with unexplained recurrent abortion

Imai¹,

Takakuwa²,

Ishii³

et al. 2001

Journal of Perinatal Medicine

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In order to clarify the genetic background of recurrent spontaneous abortion, the frequency of HLA-A, -B, and -C alleles was analyzed in eighty-nine patients with a history of unexplained primary recurrent abortion. The frequency of each HLA-A, -B, and -C antigen allele was calculated in patients with recurrent abortion and their husbands, and compared with the frequencies in the general population represented by 207 individuals in the Niigata district of Japan. The incidence of individuals homozygous for the HLA-A, -B, and -C alleles was also compared between the patient group and the control group. The frequency of HLA-B35 in the patient group (5 of 89, 5.6%) was significantly lower than in the general population (40 of 207, 19.3%) (Odds Ratio, 0.25; 95% Confidence Interval, 0.09-0.65; P < 0.005; Pc, not significant). The frequencies of other HLA-A, -B, and -C alleles were not significantly different between the patient group and the general population. No significant difference in the frequency of HLA-A, -B, and -C alleles was observed between the husband group and the general population. The incidence of individuals homozygous for HLA-A, -B, or -C alleles in the patient group was not significantly different from the general population. The significantly lower frequency of HLA-B35 in patients with unexplained recurrent abortion suggests that the Th2-associated immune reactions may be lacking in such patients, as it has been reported that an enhanced Th2 response in conjunction with a decreased T Th1 response is a common immune reaction in HLA-B35-positive individuals.

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Possible Susceptibility of the HLA‐DPB10402 and HLA‐DPB104 Alleles to Unexplained Recurrent Abortion: Analysis by means of Polymerase Chain Reaction–Restricted Fragment Length Polymorphism Method

Abstract: These findings suggest a possible new class II association with patient population of unexplained recurrent abortion.

Cited by 16 publications

References 28 publications

HLA allele associations in idiopathic recurrent spontaneous abortion patients from India

HLA allele associations in idiopathic recurrent spontaneous abortion patients from India

Maternal HLA class II alleles and haplotypes associated with altered risk of recurrent pregnancy loss: A case‐control study

HLA-class I antigens in patients with unexplained recurrent abortion

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