Possible strategy to use differential mobility spectrometry in real time applications

Anttalainen, Osmo; Puton, Jarosław; Kontunen, Anton; Karjalainen, Markus; Kumpulainen, Pekka; Oksala, Niku; Safaei, Zahra; Roine, Antti

doi:10.1007/s12127-019-00251-1

Cited by 12 publications

(9 citation statements)

References 17 publications

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“…DMS separates ions in the gas phase based upon subtle differences in their chemical structures (e.g., mass, shape, center of mass and dipole moment), giving separative power that is orthogonal to both MS and HPLC [ 218 ]. A current limitation is that the method is relatively time consuming and data intensive [ 219 ].…”

Section: Future Directions/perspectivesmentioning

confidence: 99%

Proteomics, Personalized Medicine and Cancer

Zhang

Zhou

et al. 2021

Cancers

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As of 2020 the human genome and proteome are both at >90% completion based on high stringency analyses. This has been largely achieved by major technological advances over the last 20 years and has enlarged our understanding of human health and disease, including cancer, and is supporting the current trend towards personalized/precision medicine. This is due to improved screening, novel therapeutic approaches and an increased understanding of underlying cancer biology. However, cancer is a complex, heterogeneous disease modulated by genetic, molecular, cellular, tissue, population, environmental and socioeconomic factors, which evolve with time. In spite of recent advances in treatment that have resulted in improved patient outcomes, prognosis is still poor for many patients with certain cancers (e.g., mesothelioma, pancreatic and brain cancer) with a high death rate associated with late diagnosis. In this review we overview key hallmarks of cancer (e.g., autophagy, the role of redox signaling), current unmet clinical needs, the requirement for sensitive and specific biomarkers for early detection, surveillance, prognosis and drug monitoring, the role of the microbiome and the goals of personalized/precision medicine, discussing how emerging omics technologies can further inform on these areas. Exemplars from recent onco-proteogenomic-related publications will be given. Finally, we will address future perspectives, not only from the standpoint of perceived advances in treatment, but also from the hurdles that have to be overcome.

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Section: Future Directions/perspectivesmentioning

confidence: 99%

Proteomics, Personalized Medicine and Cancer

Zhang

Zhou

et al. 2021

Cancers

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“…Two-dimensional spectrum is obtained by altering the strength RF of the electric fields and recording the amount of ionized molecules landing on the detector element at each pair of fields. The operation of the DMS is recently presented in detail elsewhere [11].…”

Section: Dms Sensormentioning

confidence: 99%

Recovery characteristics of different tube materials in relation to combustion products

Karjalainen

Kontunen

Mäkelä

et al. 2020

Int. J. Ion Mobil. Spec.

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Common challenge in gas analyzers such as Ion Mobility Spectrometers (IMS) integrated into a measurement system is the reduced analysis speed that is partially limited by the temporal carry-over of sample molecules. It is caused by adsorption and absorption of the molecules into the gas tubes of the analyzer. We studied the recovery times of common tube materials: polyether ether ketone (PEEK), polytetrafluoroethylene (PTFE), fluorinated ethylene propylene (FEP), polyethylene (PE), steel 316 L, parylene C coated steel and Silconert® coated steel from organic combustion products. The tests were performed in two temperatures, at 25 °C and at 70 °C. In addition, detailed analysis was performed for PTFE tube material at 33, 50, 70 and 100 °C to observe the temperature relation of desorption. Uncoated steel was found to have the best performance in increased temperature applications due lack of absorption. Major advantages from coatings compared to plane steel were not found. Plastics were found suitable materials in lower temperatures where adsorption exceeds absorption.

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“…In recent decades, various techniques have already shown promising results in respiratory analysis, including quartz crystal microbalance (QCM), [ 34 ] ion mobility spectrometry (IMS), [ 35,36 ] proton‐transfer‐reaction mass spectrometry (PTR‐MS), [ 37 ] gas chromatography, [ 38 ] surface acoustic wave (SAW), [ 39–41 ] differential mobility spectroscopy (DMS), [ 42 ] thin film transistor (TFT), [ 43–45 ] chemoresistive sensor, [ 46–50 ] and so on. However, a majority of them require an external power source and batteries are widely adopted.…”

Section: Introductionmentioning

confidence: 99%

Self‐Powered Respiration Monitoring Enabled By a Triboelectric Nanogenerator

et al. 2021

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In mammals, physiological respiration involves respiratory cycles of inhaled and exhaled breaths, which has traditionally been an underutilized resource potentially encompassing a wealth of physiologically relevant information as well as clues to potential diseases. Recently, triboelectric nanogenerators (TENGs) have been widely adopted for self‐powered respiration monitoring owing to their compelling features, such as decent biocompatibility, wearing comfort, low‐cost, and high sensitivity to respiration activities in the aspect of low frequency and slight amplitude body motions. Physiological respiration behaviors and exhaled chemical regents can be precisely and continuously monitored by TENG‐based respiration sensors for personalized health care. This article presents an overview of TENG enabled self‐powered respiration monitoring, with a focus on the working principle, sensing materials, functional structures, and related applications in both physical respiration motion detection and chemical breath analysis. Concepts and approaches for acquisition of physical information associated with respiratory rate and depth are covered in the first part. Then the sensing mechanism, theoretical modeling, and applications related to detection of chemicals released from breathing gases are systemically summarized. Finally, the opportunities and challenges of triboelectric effect enabled self‐powered respiration monitoring are comprehensively discussed and criticized.

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Possible strategy to use differential mobility spectrometry in real time applications

Cited by 12 publications

References 17 publications

Proteomics, Personalized Medicine and Cancer

Proteomics, Personalized Medicine and Cancer

Recovery characteristics of different tube materials in relation to combustion products

Self‐Powered Respiration Monitoring Enabled By a Triboelectric Nanogenerator

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