Possible Roles of the Xenobiotic Transporter P-glycoproteins Encoded by the MDR1 3435 C＞T Gene Polymorphism in Differentiated Thyroid Cancers

Abstract

Background: P-glycoprotein (Pgp), encoded by the multidrug resistance 1 (MDR1) gene, is an efflux transporter which plays an important role in pharmacokinetics. The current preliminary study was designed to determine associations between a germ-line polymorphism in the MDR1 gene with differentiated thyroid carcinoma (DTC).

EGF Reverses Multi-drug Resistance via the p-ERK Pathway in HepG2/ADM and SMMC7721/ADM Hepatocellular Carcinoma Models

“…This phenomenon is referred to as MDR and is inherently expressed by some tumor types, while others acquire MDR after exposure to chemotherapy treatment (Nishimoto et al, 2006;Chen et al, 2013;Ozdemir et al, 2013;Ren et al, 2012;Zhu et al, 2013;Roy et al, 2014). To elucidate if p-ERKs involved in reversal of Multi-Drug resistance by EGF in HepG2/ADM and SMMC7721/ADM cells, cell apoptosis and cell cycle distribution were analyzed by FCM.…”

Thyroid nodules with indeterminate cytology: prospective comparison between 18F-FDG-PET/CT, multiparametric neck ultrasonography, 99mTc-MIBI scintigraphy and histology

“…One possible, albeit speculative, explanation could be related to the low MIBI ratio evaluated in the late images. This tracer behaviour may be associated with the multi-drug resistance protein often expressed by DTC and, in some cases, related to poor prognosis (39). In this setting, DTC with low MIBI uptake in late images might be more aggressive, thus presenting BRAF mutation.…”

Influence of Genotype and Haplotype of MDR1 (C3435T, G2677A/T, C1236T) on the Incidence of Breast Cancer - a Case-Control Study in Jordan

“…It has been suggested that single nucleotide polymorphisms (SNPs) of MDR1 could influence the level of expression of enhancer and promoter sequences that may influence the efficacy of processing of the premRNAs, and as a consequence, may influence mRNA stability (Ozdemir et al, 2013;Du et al, 2014). Modulation of the P-gp transporting function may contribute to mutagenesis through accumulation of exogenous toxins and increase the risk of cancer development.…”

“…It acts as an efflux pump and provides cell protection against various substances such as organic cations, amino acids, polysaccharides, proteins, and some antibiotics (Kreile et al, 2014;Pongstaporn et al, 2015). Accordingly, kidney, adrenal gland, liver, blood-brain barrier, placenta, and testis contain high amount of P-gp (Ozdemir et al, 2013).…”

“…MDR1 gene is a member of the ABC (ATPbinding cassette) family that encodes a membrane-bound phosphoglycoprotein (P-gp). The MDR1 gene is located on chromosome 7 and contains 28 exons, and the coding region that leads to change in protein sequence accounts for less than 5% of the total (Ozdemir et al, 2013) . It acts as an efflux pump and provides cell protection against various substances such as organic cations, amino acids, polysaccharides, proteins, and some antibiotics (Kreile et al, 2014;Pongstaporn et al, 2015).…”