Possible Roles of KIR2DL4 Expression on uNK Cells in Human Pregnancy

Yan, Wei‐Hua; Lin, Aifen; Chen, Baoguo; Zhou, Mengya; Dai, Meizhen; Chen, Xue-Jiao; Gan, Linghong; Zhu, Min; Shi, Wei-Wu; Li, Boli

doi:10.1111/j.1600-0897.2007.00469.x

Cited by 56 publications

(50 citation statements)

References 36 publications

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“…Normal ve patolojik gebeliklerde NK hücre reseptörlerinin önemini açığa çıkaran birçok çalışma yayımlanmıştır. [25][26][27] NK hücre reseptörlerinin araştırıldığı bir çalışmada, tekrarlayan spontan düşükleri olan kadınlarda inhibitr KIR'lerin kontrollere göre daha az olduğu bulunmuştur. 27 Bu çalışmada, alloimmün düşüklerde daha az sayıda inhibitör KIR olduğu ve bu düşüklerin trofoblastik HLA klas I moleküllerinin uygun inhibitör KIR olmayan uNK hücreleri tarafından tanınmasın-dan kaynaklandığı kanısına varılmıştır.…”

Section: Discussionunclassified

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Role of Uterine Natural Killer Cells in Early Pregnancy Loss

Aydın¹,

Aydın²,

Saygili³

2015

Turkiye Klinikleri J Gynecol Obst

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Section: Discussionunclassified

“…Yan ve ark.nın yaptığı çalışma bu çalışma ile benzer sonuç-lar sunsa da Witt ve ark.nın sonuçları bu sonuçlarla uyum göstermemektedir. 25,26 Bu farklılıkların, ça-lışma grubundaki populasyonun farklılıklarından kaynaklandığı düşünülmektedir.…”

Section: Discussionunclassified

Role of Uterine Natural Killer Cells in Early Pregnancy Loss

Aydın¹,

Aydın²,

Saygili³

2015

Turkiye Klinikleri J Gynecol Obst

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“…Yan et al [30] reported that the surface expression of KIR2DL4 receptors have been significantly higher in women who had recurrent miscarriage than the control group. In our study, we did not assess the surface expression of KIR2DL4, but there was no significant difference between two groups for the KIR2DL4 gene frequency.…”

Section: Discussionmentioning

confidence: 99%

“…Seven genes within this KIR repertoire are known to encode receptors for the HLA class I molecules expressed on trophoblasts; KIR2DL1, KIR2DL2, KIR2DL3, KIR2DS1, KIR2DS2, KIR2DS4, and KIR2DL4 [14,30]. KIRs, by their inhibiting and activating isotypes have a substantial role on organizing the NK cell activity [5].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of KIR genes in recurrent miscarriage

Öztürk

Şahin

Karaçor

et al. 2012

J Assist Reprod Genet

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Purpose Natural killer (NK) cells express killer immunoglobulinlike receptors (KIRs) which recognize HLA class I molecules on trophoblasts. KIRs could either activate NK cells or inhibit them to produce soluble factors necessary for the maintenance of pregnancy, thus they are suspected of being involved in the causes of recurrent miscarriage. The aim of this study was to evaluate whether there is any possible association between KIR genes, genotypes and recurrent miscarriage. Methods The present study was carried out on 40 women who had unexplained recurrent miscarriage and 90 controls. Sequence-specific oligonucleotide probes analysis were used to investigate 16 KIR genes. All data were statistically analyzed by Fisher Exact Test. Results The rate of Bx genotypes that consists elevated number of activating KIR genes was significantly higher (p00.014) in women with recurrent miscarriage when compared with the control group. Additionally, the frequency of AA genotype (AA1) of the subjects in the study group was significantly lower than the frequency of the subjects in the control group (p00,014). Furthermore, there were no statistically significant differences in the frequencies of the individual KIR genes between women with recurrent miscarriage and the control group. Conclusions Inclined balance of KIRs toward an activating state in NK cells may contribute to recurrent miscarriage.

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“…Therefore, it has been suggested that NK cells expressing KIR2DL4 might be involved in the maintenance of pregnancy and in cancer progression (8,9). Such hypotheses were derived from analyses of NK cells, and, to the best of our knowledge, neither the role(s) nor expression of KIR2DL4 has been examined in human mast cells.…”

Section: Introductionmentioning

confidence: 99%

The Killer Cell Ig-like Receptor 2DL4 Expression in Human Mast Cells and Its Potential Role in Breast Cancer Invasion

Ueshima

Kataoka

Hirata

et al. 2015

Cancer Immunology Research

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The killer-cell Ig-like receptor (KIR) 2DL4 (CD158d) acts as a receptor for human leukocyte antigen (HLA)-G and is expressed on almost all human natural killer (NK) cells. The expression and function of KIR2DL4 in other hematopoietic cells is poorly understood. Here, we focused on human mast cells, which exhibit cytotoxic activity similar to that of NK cells. KIR2DL4 was detected in all examined human cultured mast cells established from peripheral blood derived from healthy volunteers (PB-mast), the human mast cell line LAD2, and human nonneoplastic mast cells, including those on pathologic specimens. An agonistic antibody against KIR2DL4 decreased KIT-mediated and IgE-triggered responses, and enhanced the granzyme B production by PB-mast and LAD2 cells, by activating Src homology 2-containing protein tyrosine phosphatase (SHP-2). Next, we performed a coculture assay between LAD2 cells and the HLA-G þ cancer cells, MCF-7 and JEG-3, and showed that KIR2DL4 on LAD2 cells enhanced MMP-9 production and the invasive activity of both cell lines via HLA-G. Immunohistochemical analysis revealed that the direct interaction between HLA-G þ breast cancer cells and KIR2DL4 þ tissue mast cells (observed in 12 of 36 cases; 33.3%) was statistically correlated with the presence of lymph node metastasis or lymphvascular invasion (observed in 11 of 12 cases; 91.7%; x 2 ¼ 7.439; P < 0.01; degrees of freedom, 1) in the clinical samples. These findings suggest that the KIR2DL4 on human mast cells facilitates HLA-G-expressing cancer invasion and the subsequent metastasis.

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Possible Roles of KIR2DL4 Expression on uNK Cells in Human Pregnancy

Abstract: Our data suggest that KIR2DL4 might play a crucial implication for human pregnancy.

Cited by 56 publications

References 36 publications

Role of Uterine Natural Killer Cells in Early Pregnancy Loss

Role of Uterine Natural Killer Cells in Early Pregnancy Loss

Evaluation of KIR genes in recurrent miscarriage

The Killer Cell Ig-like Receptor 2DL4 Expression in Human Mast Cells and Its Potential Role in Breast Cancer Invasion

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