Possible role of α1- and α2-adrenoceptors in the modulation of the sympathetic component of the baroreflex

Huchet, Anne Marie; Doursout, Marie–Françoise; Ostermann, Gérard; Chelly, Jacques E.; Schmitt, Henri

doi:10.1016/0028-3908(83)90196-x

Cited by 12 publications

(1 citation statement)

References 10 publications

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“…The significant decrease in MR after the i.c.v. injection of 10 pg clonidine may have been the consequence of a reflex response to the increase in MAP as well as an enhancement of the baroreceptor reflex by a central action of clonidine (Huchet et al 1983). The significant decrease in plasrna nodrenaline level and the small and nonsignificant decrease in adrenaline concentration after the i .c .…”

Section: Biseussisnmentioning

confidence: 97%

Differential cardiovascular effects of central clonidine and B-HT 920 in conscious rats

King¹,

Pang²

1988

Can. J. Physiol. Pharmacol.

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The effect of intracerebroventricular (i.c.v.) injection of the alpha 2-adrenoceptor agonists clonidine and B-HT 920 on mean arterial pressure (MAP), heart rate (HR), and plasma concentrations of noradrenaline and adrenaline was examined in conscious unrestrained rats. The injection of 1.0 microgram clonidine significantly decreased MAP and slightly decreased HR. Plasma noradrenaline and adrenaline levels were slightly but not significantly decreased after the injection of 1 microgram clonidine. In contrast, the injection of 0.1-10.0 micrograms B-HT 920 increased MAP and decreased HR. Plasma noradrenaline and adrenaline levels were slightly increased after the injection of the 1- and 10-micrograms doses. The i.c.v. injection of the alpha 2-antagonist rauwolscine slightly but not significantly increased MAP and plasma noradrenaline and adrenaline levels. The responses to i.c.v. injection of clonidine and B-HT 920 were not changed by prior administration of rauwolscine. Neither the pressor response to B-HT 920 nor the depressor response to clonidine was abolished by rauwolscine, suggesting that neither response was mediated by alpha 2-adrenoceptors.

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Section: Biseussisnmentioning

confidence: 97%

Differential cardiovascular effects of central clonidine and B-HT 920 in conscious rats

King¹,

Pang²

1988

Can. J. Physiol. Pharmacol.

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Cardiovascular effects in rats of alpha1 and alpha2 adrenergic agents injected into the nucleus tractus solitarii

Kubo

Kihara

Hata

et al. 1987

Naunyn-Schmiedeberg's Arch Pharmacol

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The cardiovascular effects of selective alpha 1 and alpha 2 agonists and antagonists injected into the nucleus tractus solitarii (NTS) were studied in urethane-anesthetized rats. Methoxamine (0.3-3 micrograms) injected bilaterally into the NTS caused a dose-dependent increase in blood pressure and heart rate. Phenylephrine (6 micrograms) and an imidazolidine derivative St 587 (3 micrograms) similarly injected also produced an increase in blood pressure, whereas alpha-methylnoradrenaline and an azepine derivative B-HT 920 (1 and 3 micrograms) caused a decrease in blood pressure and heart rate. The pressor response to methoxamine (1 microgram) was markedly inhibited by prazosin (0.3 microgram) injected into the same sites or hexamethionum (25 mg/kg, i.v.). Prazosin (0.3 microgram) alone injected bilaterally into the NTS did not affect the blood pressure, while yohimbine (0.1 microgram) similarly injected increased the pressure. These results suggest that in the rat NTS there exist alpha 1 adrenoceptors responsible for an increase in arterial pressure. The NTS alpha 2 adrenoceptors seem to be involved in the tonic regulation of arterial pressure.

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The effect of yohimbine, Wy 26392 and idazoxan on sympathetic nerve activity

Ramage

Tomlinson

1985

European Journal of Pharmacology

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Possible role of α1- and α2-adrenoceptors in the modulation of the sympathetic component of the baroreflex

Cited by 12 publications

References 10 publications

Differential cardiovascular effects of central clonidine and B-HT 920 in conscious rats

Differential cardiovascular effects of central clonidine and B-HT 920 in conscious rats

Cardiovascular effects in rats of alpha1 and alpha2 adrenergic agents injected into the nucleus tractus solitarii

The effect of yohimbine, Wy 26392 and idazoxan on sympathetic nerve activity

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