Possible Role of Vitamin D in the Pathogenesis of Lichen Planus: Review Article

Abstract

Background: The skin, mucosa, and extremities can be affected by lichen planus (LP), a chronic lichenoid inflammatory condition. Rich inflammatory T cells infiltration, which travel in a band-like pattern in the upper section of the dermis, is a characteristic hallmark of LP. There have been numerous descriptions of the disease's various subtypes. Vitamin D regulates immunological function, making it a key factor in the development and progression of LP. Objective: Review of possible role of vitamin D in the pathogenesis of Lichen Planus. Methods: We scoured scholarly papers and databases including PubMed, Google Scholar, and Science Direct for information on Lichen Planus and vitamin D between May 1986 and January 2022, however only the latest or most comprehensive study was considered. The authors also assessed the usefulness of references taken from similar books. Documents written in languages other than English have been overlooked because of a lack of funding to translate them. Unpublished articles, oral talks, conference abstracts, and dissertations were all generally agreed upon to not constitute valid scientific investigation. Conclusion: Vitamin D deficiency reduces Th2 cells and other T cells that are included among inflammation processes like T helper cells 11 and 17. This makes a bad situation much worse in inflammatory disorders like Lichen Planus.