Possible role of TORCH agents in congenital malformations in Gorgan, northern Islamic Republic of Iran

Golalipour, Mohammad Jafar; Khodabakhshi, Behnaz; Ghaemi, E

doi:10.26719/2009.15.2.330

Cited by 11 publications

(12 citation statements)

References 10 publications

(8 reference statements)

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“…Serologic testing of both mothers and neonates could be useful for detecting malformations (Golalipour et al 2009). All antenatal cases with bad obstetric history should be routinely screened for TORCH complex as early diagnosis and appropriate intervention of the infection will help in proper management of these cases (Turbadkar et al 2003).…”

Section: Prevalence Of Serum Antibodies To Torch Infections Among Thementioning

confidence: 99%

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Lamichhane

Pudasaini

Upadhyay

et al. 2015

Nepal Journal of Science and Technology

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The primary infection of Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV) and Herpes simplex virus (HSV) abbreviated as TORCH, remain a major problem in the women of child bearing age in Nepal. The main aim of this study was to determine the seroprevalence of TORCH infections among the women of child bearing age visiting the National Public Health Laboratory (NPHL), Kathmandu. Serum samples collected from 302 patients were tested for TORCH infections by IgM Enzyme Linked Immunosorbent Assay (ELISA). The seropositivity rate was found to be 18.82% (54/287) for T. gondii, 10.07% (28/278) for Rubella, 16.49% (46/279) for CMV and 23.34% (67/287) for HSV. The seropositivity rates in pregnant women were 17.92% (19/106) for T. gondii, 11.54% (12/104) for Rubella, 19.23% (20/104) for CMV and 25% (26/104) for HSV, the statistical association of TORCH infections with pregnancy was insignificant (P>0.05). Similarly, the seropositivity rates in women with bad obstetric history (BOH) were 17.84% (43/241) for T. gondii, 11.06% (26/235) for Rubella, 18.57% (44/237) for CMV and 26.14% (63/241) for HSV. The statistical association of CMV and HSV with previous obstetric performance were significant (P>0.05) while that of T. gondii and Rubella were insignificant (P<0.05). The seropositivity rate was found to be highest for HSV infection (23.34%) followed by T. gondii (18.82%), Cytomegalovirus (16.49%) and Rubella (10.07%).DOI: http://dx.doi.org/njst.v15i2.12120Nepal Journal of Science and Technology Vol. 15, No.2 (2014) 85-90

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Section: Prevalence Of Serum Antibodies To Torch Infections Among Thementioning

confidence: 99%

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Lamichhane

Pudasaini

Upadhyay

et al. 2015

Nepal Journal of Science and Technology

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“…The higher results might be related to the wider range of age of suggestive infants included in that study as compared to this study. Higher results 20% of HCMV infection as indicated by specific IgM among symptomatic neonates was found in India (26) , while lower results 1.6% and 2% were reported among symptomatic infants in Iran and Palestine respectively using the same test (27,28) . The variation among these results and result of this study may reflect the variation of HCMV prevalence in different countries (29) .…”

Section: Discussionmentioning

confidence: 93%

Human Cytomegalovirus Infection Among Neonates With Symptomatic Congenital Infections and Birth Defects

علوان¹,

عارف²,

الصفار³

et al. 2016

IJMS

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“…In this study Toxoplasma specific IgM was 5.17% which correlates with the findings of Golalipour et al in Iran. They repoted 3.2% IgM anti Tox antibody 4 . But in this study no cases were infected by Toxoplasma gondi alone.…”

Section: Resultsmentioning

confidence: 99%

“…Congenital malformations caused by these pathogens are important causes of morbidity, mortality and disability and are found in approximately 2% -3% of neonates. Congenital malformations have a direct impact on the family and place a financial burden on medical, educational and support services 4 . This acronym was proposed to simplify diagnostic procedures in severely ill children and to impose clearer structure in the large differential diagnosis of congenital infections 1 .…”

Section: Introductionmentioning

confidence: 99%

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Seroprevalence of TORCH Infections in Children

Biswas

Badruddoza

Sultana

2018

Chatt Maa Shi Hosp Med Coll J

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Background : The acronym “TORCH” was introduced to highlight a group of pathogens that cause a congenital and perinatal infections: Toxoplasma gondi, rubella virus, Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV). These pathogens are often associated with congenital anomalies. Congenital malformations have a direct impact on the family. This study was undertaken to detect the serological evidence of TORCH infections in children, by establishing the presence of specific IgM antibodies. Methods: During the period 1st June 2016 to 30th May 2017, 58 suspected TORCH infection cases were included from Paediatrics Department of CMOSH for TORCH antibody detection. The children were in the age of 0 day to 1 year with an average age of 3.3±2.59 months. The serum samples were tested forIgM and IgG antibodies against TORCH agents by using enzyme linked immunoassay method (ELISA). Results: Among the 58 children, seropositivity was found in 55 (94.82%) cases. Of the 55 seropositive cases serological evidence for combination of IgM and IgG with any one of the TORCH agents was detected in 25 (43.10%) and IgG alone was detected in 30 (51.72%) children. IgM/IgG antibody positivity to Toxoplasma, Rubella, CMV and HSV was 21(36.21%), 50(86.21%), 52(89.66%) and 8(13.79%) respectively. IgM anti-CMV were observed in highest number of cases 19(32.76%), followed by IgM anti-rubella 7(12.07%). IgM against HSV and Toxoplasma were found in equal number of cases, 3(5.17%) each. Conclusions: Awareness amongst clinicians and mothers about TORCH infections and their consequences should be developed. Chatt Maa Shi Hosp Med Coll J; Vol.17 (1); Jan 2018; Page 13-16

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Possible role of TORCH agents in congenital malformations in Gorgan, northern Islamic Republic of Iran

Cited by 11 publications

References 10 publications

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Prevalence of Serum Antibodies to TORCH Infections among the Women of Child Bearing Age Visiting National Public Health Laboratory, Teku

Human Cytomegalovirus Infection Among Neonates With Symptomatic Congenital Infections and Birth Defects

Seroprevalence of TORCH Infections in Children

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