Possible role of TGF β1 in inflammatory pseudotumor associated with multiple neuroendocrine tumors of the small intestine

Udelnow, Andrej; Jechorek, Doerthe; Wex, Cora; Klose, Silke; Pech, Maciej; Reinhold, Annegret; Meyer, Frank

doi:10.1016/j.prp.2015.06.005

Cited by 2 publications

(1 citation statement)

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“…The very rare inflammatory myofibroblastic tumors are associated with malignancies such as malignant NETs of the small intestine with lymphatic and hepatic metastasis and a mesenteric location of the abovementioned tumor. In this case, TGF β1 Levels are significantly increased, and it is a diagnostic marker, especially for follow-up[ 50 ].…”

Section: Diagnosismentioning

confidence: 99%

Molecular factors, diagnosis and management of gastrointestinal tract neuroendocrine tumors: An update

Pavlidis¹,

Pavlidis²

2022

WJCC

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The prevalence of gastrointestinal neuroendocrine tumors (GI-NETs) is increasing, and despite recent advances in their therapy, it remains inadequate in patients with advanced well-differentiated neuroendocrine tumors. These tumors present many challenges concerning the molecular basis and genomic profile, pathophysiology, clinicopathological features, histopathologic classification, diagnosis and treatment. There has been an ongoing debate on diagnostic criteria and clinical behavior, and various changes have been made over the last few years. Neuroendocrine carcinoma of the gastrointestinal system is a rare but highly malignant neoplasm that is genetically distinct from gastrointestinal system neuroendocrine tumors (NETs). The diagnosis and management have changed over the past decade. Emerging novel biomarkers and metabolic players in cancer cells are useful and promising new diagnostic tools. Progress in positron emission tomography-computerized tomography and scintigraphy with new radioactive agents ( 64 Cu-DOTATATE or 68 Ga-DOTATATE) replacing enough octreoscan, has improved further the current diagnostic imaging. Promising results provide targeted therapies with biological agents, new drugs, chemotherapy and immunotherapy. However, the role of surgery is important, since it is the cornerstone of management. Simultaneous resection of small bowel NETs with synchronous liver metastases is a surgical challenge. Endoscopy offers novel options not only for diagnosis but also for interventional management. The therapeutic option should be individualized based on current multidisciplinary information.

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Section: Diagnosismentioning

confidence: 99%