Possible Role of Serum 25-Hydroxyvitamin D in Black–White Health Disparities in the United States

Grant, William B.; Peiris, Alan N.

doi:10.1016/j.jamda.2010.03.013

Cited by 97 publications

(78 citation statements)

References 151 publications

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“…These cells were cultured and differentiated into adipocytes following the method described earlier (11 2 D 3 for 2 h followed by CG or HG exposure for the next 20 h. Mannitol was used as an osmolarity control. In the mannitol group, cells were exposed to 18 mM mannitol because the medium contains 7 mM glucose.…”

Section: Methodsmentioning

confidence: 99%

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Vitamin D Up-regulates Glucose Transporter 4 (GLUT4) Translocation and Glucose Utilization Mediated by Cystathionine-γ-lyase (CSE) Activation and H2S Formation in 3T3L1 Adipocytes

Manna

Jain

2012

Journal of Biological Chemistry

141

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Section: Methodsmentioning

confidence: 99%

“…A review of the literature suggests that higher concentrations of circulating vitamin D are associated with a substantial decrease in cardiovascular disease, type 2 diabetes, and metabolic syndrome (2). Supplementation with vitamin D decreases blood glucose and HbA1c in both type 2 and type 1 diabetic patients (3,4).…”

mentioning

confidence: 99%

Vitamin D Up-regulates Glucose Transporter 4 (GLUT4) Translocation and Glucose Utilization Mediated by Cystathionine-γ-lyase (CSE) Activation and H2S Formation in 3T3L1 Adipocytes

Manna

Jain

2012

Journal of Biological Chemistry

141

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“…5 Vitamin D deficiency has even been postulated to be the factor underlying the health disparities often shown between African Americans and White Americans through the effect on paracrine and autocrine mechanisms that affect health outcomes. 6 Vitamin D deficiency is a universal problem, with an estimate of about 1 billion people suffering from it worldwide. 7 However, the prevalence is widely variable among countries.…”

Section: Introductionmentioning

confidence: 99%

Comparison of vitamin D deficiency in Saudi married couples

2012

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BACKGROUND/OBJECTIVE: Vitamin D deficiency is highly prevalent in Saudi Arabia. The study objective was to compare vitamin D deficiency in Saudi married couples. SUBJECTS/METHODS: This cross-sectional study was carried out in the Royal Guard primary health care center in Riyadh, Saudi Arabia on a consecutive sample of 50 Saudi married couples attending the center without complaints related to vitamin D deficiency. Data were collected through an interview questionnaire addressing the risk factors and dietary habits. Quantitative determination of total 25-hydroxy vitamin D in blood was done by Electro-Chemical Luminescence assay. Fieldwork was carried out from December 2010 to January 2011. RESULTS: Men had higher sun exposure (P ¼ 0.001), more use of light clothes at home (P ¼ 0.002) and more intake of milk (P ¼ 0.023) and soft drinks (P ¼ 0.001). Vitamin D was higher in men with mean difference about 9 nmol/l (Po0.001). The prevalence of vitamin D deficiency (o25 nmol/l) was 70% in women, compared with 40% in men (P ¼ 0.001). Multivariate analysis identified male gender, physical activity and the intake of milk as statistically significant positive independent predictors of vitamin D level, adjusted for factors as age, sun exposure, clothing, skin color, BMI, soft drinks and animal protein intake. CONCLUSION: Vitamin D deficiency is very high among Saudi married couples, especially wives. Female gender is an independent predictor of lower vitamin D level, in addition to sedentary lifestyle and low milk consumption. There is a need to revise the levels set for the diagnosis of vitamin D deficiency or insufficiency in the study region.

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“…Several recent reviews discuss the health benefits of vitamin D (Grant and Boucher, 2011;Grant and Peiris, 2010;Holick, 2007Holick, , 2011Norman, 2008). In a project under way for the Vitamin D Council (San Luis Obispo, CA, USA), I have identified B100 types of disease for which low serum 25-hydroxyvitamin D (25(OH)D) increases risk of incidence or premature death or for which some of the standard drug or surgical treatments reduce serum 25(OH)D levels.…”

Section: Introductionmentioning

confidence: 99%

An estimate of the global reduction in mortality rates through doubling vitamin D levels

Grant

2011

Eur J Clin Nutr

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Background/Objectives: The goal of this work is to estimate the reduction in mortality rates for six geopolitical regions of the world under the assumption that serum 25-hydroxyvitamin D (25(OH)D) levels increase from 54 to 110 nmol/l. Subjects/Methods: This study is based on interpretation of the journal literature relating to the effects of solar ultraviolet-B (UVB) and vitamin D in reducing the risk of disease and estimates of the serum 25(OH)D level-disease risk relations for cancer, cardiovascular disease (CVD) and respiratory infections. The vitamin D-sensitive diseases that account for more than half of global mortality rates are CVD, cancer, respiratory infections, respiratory diseases, tuberculosis and diabetes mellitus. Additional vitamin D-sensitive diseases and conditions that account for 2 to 3% of global mortality rates are Alzheimer's disease, falls, meningitis, Parkinson's disease, maternal sepsis, maternal hypertension (pre-eclampsia) and multiple sclerosis. Increasing serum 25(OH)D levels from 54 to 110 nmol/l would reduce the vitamin D-sensitive disease mortality rate by an estimated 20%. Results: The reduction in all-cause mortality rates range from 7.6% for African females to 17.3% for European females. Reductions for males average 0.6% lower than for females. The estimated increase in life expectancy is 2 years for all six regions. Conclusions: Increasing serum 25(OH)D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake and/or frequent moderate UVB irradiance with sufficient body surface area exposed.

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Possible Role of Serum 25-Hydroxyvitamin D in Black–White Health Disparities in the United States

Cited by 97 publications

References 151 publications

Vitamin D Up-regulates Glucose Transporter 4 (GLUT4) Translocation and Glucose Utilization Mediated by Cystathionine-γ-lyase (CSE) Activation and H2S Formation in 3T3L1 Adipocytes

Vitamin D Up-regulates Glucose Transporter 4 (GLUT4) Translocation and Glucose Utilization Mediated by Cystathionine-γ-lyase (CSE) Activation and H2S Formation in 3T3L1 Adipocytes

Comparison of vitamin D deficiency in Saudi married couples

An estimate of the global reduction in mortality rates through doubling vitamin D levels

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