Possible Role of Phosphatidylcholine and Sphingomyelin on Fumonisin B1-mediated Toxicity

Abstract

A major corn-related mycotoxin, fumonisin B1 (FB1), continues to attract attention of researchers as well as risk-assessors due to the diverse toxicological characteristics, including distinct target tissues in different animal species and opposite susceptibility in males and females in mice and rats. More than thirty years passed since the structure identification as a sphingoid-like chemical, but the causal mechanism of the toxicity remains obscure in spites of extensive studies. Considerable amounts of knowledge have been accumulated on the biochemical/toxicological actions of FB1, but the influence on lipid dynamics and mobilization in the body has not been focused well in relation to the FB1-mediated toxicity. Considerable influences of this toxin on mobilization of sphingolipids and phospholipids and also on adaptive changes in their compositions in tissues are implicated from recent studies on FB1-interacting ceramide synthases. Accumulated patho-physiological data also suggest a possible role of hepatic phospholipid on FB1-mediated toxicity. Thus, a mechanism of FB1-mediated toxicity is discussed in relation to the mobilization of phospholipids and sphingolipids in the body in this context.

Mycotoxin: Its Impact on Gut Health and Microbiota

“…In the intestinal epithelial cells, sphinganine accumulation blocked G0/G1 phase in cell and resulted in growth inhibition and apoptosis (Angius et al, 2015 ). The accumulation of sphinganine also altered glycoprotein distribution in the jejunum and caused an increase in transepithelial passage of FB1 (Yamazoe et al, 2017 ). In addition, FB1 altered the integrity of intestinal barrier by suppressing tight junction (TJ) protein expression level (Romero et al, 2016 ).…”

Research progress in simultaneous detection of mycotoxins in traditional Chinese medicine

“…Different types of fumonins can be divided into FA, FB, FC and FP because of the different substituents on the carbon skeleton, among which B 1 fumonins is the most widespread and toxic. FB1 inhibits ceramide and enzyme activities and exerts its toxic effects, which seriously endangers human health [7] .…”

The importance of accounting for sex in the search of proteomic signatures of mycotoxin exposure

“…Although different -omics techniques have been applied to evaluate the effect of FB1 in different tissues [88], the changes in the proteome induced by FB1 remain to be explored. The sex-specific effects of fumonisin B1 (FB1) are widely known and have been reviewed [89]. Males and females developed different types of tumors depending on the species: hepatocellular adenomas and carcinomas were induced by FB1 in female mice but not in males, whereas male Fischer F344 rats developed renal tumors that were not seen in females [90].…”