Possible role of nutrition in the prevention of inflammatory bowel disease–related colorectal cancer: A focus on human studies

Cassotta, Manuela; Cianciosi, Danila; Giuseppe, Rachele De; Navarro-Hortal, María D.; Diaz, Yasmany Armas; Forbes‐Hernández, Tamara Y.; Pifarré, Kilian Tutusaus; Barrera, Alina Eugenia Pascual; Grosso, Giuseppe; Xiao, Jianbo; Battino, Maurizio; Giampieri, Francesca

doi:10.1016/j.nut.2023.111980

Cited by 5 publications

(3 citation statements)

References 253 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A diet rich in saturated fats [122,123], processed foods [124,125] and red meat [126,127] is a common risk factor for both IBD and CRC. A low-fibre diet is a major determinant of gut dysbiosis [125], with an increase in pathogenic phyla such as Proteobacteria and Fusobacterium and species such as E. coli together with a reduction in Faecalibacterium prausnitzii, which is considered to be the indicator of gut wellness and is associated with the reduction in inflammation in obesity and diabetes [122,128,129]. Plus, an unbalanced gut microbial profile may lead to increased calories intake and fat storage and it may modify hormones regulating metabolism and appetite and dysregulate the immune system, contributing to chronic inflammation.…”

Section: Diet and Obesitymentioning

confidence: 99%

“…A diet rich in saturated fats [ 122 , 123 ], processed foods [ 124 , 125 ] and red meat [ 126 , 127 ] is a common risk factor for both IBD and CRC. A low-fibre diet is a major determinant of gut dysbiosis [ 125 ], with an increase in pathogenic phyla such as Proteobacteria and Fusobacterium and species such as E. coli together with a reduction in Faecalibacterium prausnitzii , which is considered to be the indicator of gut wellness and is associated with the reduction in inflammation in obesity and diabetes [ 122 , 128 , 129 ]. Plus, a n unbalanced gut microbial profile may lead to increased calories intake and fat storage and it may modify hormones regulating metabolism and appetite and dysregulate the immune system, contributing to chronic inflammation.…”

Section: Diet and Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections

Mignini

Ainora

Francesco

et al. 2023

Cancers

View full text Add to dashboard Cite

Colo-rectal cancer (CRC) is undoubtedly one of the most severe complications of inflammatory bowel diseases (IBD). While sporadic CRC develops from a typical adenoma-carcinoma sequence, IBD-related CRC follows different and less understood pathways and its pathophysiological mechanisms were not completely elucidated. In contrast to chronic inflammation, which is nowadays a well-recognised drive towards neoplastic transformation in IBD, only recently was gut microbiota demonstrated to interfere with both inflammation processes and immune-mediated anticancer surveillance. Moreover, the role of microbiota appears particularly complex and intriguing when also considering its multifaceted interactions with multiple environmental stimuli, notably chronic pathologies such as diabetes and obesity, lifestyle (diet, smoking) and vitamin intake. In this review, we presented a comprehensive overview on current evidence of the influence of gut microbiota on IBD-related CRC, in particular its mutual interconnections with the environment.

show abstract

Section: Diet and Obesitymentioning

confidence: 99%

“…A diet rich in saturated fats [ 122 , 123 ], processed foods [ 124 , 125 ] and red meat [ 126 , 127 ] is a common risk factor for both IBD and CRC. A low-fibre diet is a major determinant of gut dysbiosis [ 125 ], with an increase in pathogenic phyla such as Proteobacteria and Fusobacterium and species such as E. coli together with a reduction in Faecalibacterium prausnitzii , which is considered to be the indicator of gut wellness and is associated with the reduction in inflammation in obesity and diabetes [ 122 , 128 , 129 ]. Plus, a n unbalanced gut microbial profile may lead to increased calories intake and fat storage and it may modify hormones regulating metabolism and appetite and dysregulate the immune system, contributing to chronic inflammation.…”

Section: Diet and Obesitymentioning

confidence: 99%

Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections

Mignini

Ainora

Francesco

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…Treatment of IBD with 5-aminosalicylates can significantly reduce the incidence of colon cancer ( Bonovas et al, 2017 ; Hsiao et al, 2022 ). In recent studies, targeted nutritional interventions ( Cassotta et al, 2023 ), probiotics, and other intestinal microecological agents ( Lee et al, 2022 ) were found to be effective in treating colitis-associated colon cancer (CACC). The process of IBD transformation into cancer involves complex molecular mechanisms, such as gene mutations, epigenetic alterations, persistent chronic inflammation, gut microbiota disorders, and others ( Xue et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Zhang,

Cheng,

Jian

et al. 2024

Front. Pharmacol.

View full text Add to dashboard Cite

The incidence of inflammatory bowel disease (IBD) and the associated risk of colon cancer are increasing globally. Traditional Chinese medicine (TCM) treatment has unique advantages. The Sishen Pill, a common Chinese patented drug used to treat abdominal pain and diarrhea, consists mainly of Psoraleae Fructus, Myristicae Semen, Euodiae Fructus, and Schisandra Chinensis. Modern research has confirmed that Sishen Pill and its active secondary metabolites, such as psoralen, myristicin, evodiamine, and schisandrin, can improve intestinal inflammation and exert antitumor pharmacological effects. Common mechanisms in treating IBD and colon cancer mainly include regulating inflammation-related signaling pathways such as nuclear factor-kappa B, mitogen-activated protein kinase, phosphatidylinositol 3-kinase, NOD-like receptor heat protein domain-related protein 3, and wingless-type MMTV integration site family; NF-E2-related factor 2 and hypoxia-inducible factor 1α to inhibit oxidative stress; mitochondrial autophagy and endoplasmic reticulum stress; intestinal immune cell differentiation and function through the Janus kinase/signal transducer and activator of transcription pathway; and improving the gut microbiota and intestinal barrier. Overall, existing evidence suggests the potential of the Sishen pill to improve IBD and suppress inflammation-to-cancer transformation. However, large-scale randomized controlled clinical studies and research on the safety of these clinical applications are urgently required.

show abstract

Coffee leaf polyphenol-rich extracts alleviated lipopolysaccharide-induced intestinal barrier dysfunction: Insights from a Caco-2/U937 co-culture model

Mei,

Kitts,

Chen

2024

Food Bioscience

View full text Add to dashboard Cite

Possible role of nutrition in the prevention of inflammatory bowel disease–related colorectal cancer: A focus on human studies

Cited by 5 publications

References 253 publications

Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections

Tumorigenesis in Inflammatory Bowel Disease: Microbiota-Environment Interconnections

Sishen Pill and its active phytochemicals in treating inflammatory bowel disease and colon cancer: an overview

Coffee leaf polyphenol-rich extracts alleviated lipopolysaccharide-induced intestinal barrier dysfunction: Insights from a Caco-2/U937 co-culture model

Contact Info

Product

Resources

About