Possible role of nerve growth factor and interleukin-18 in pathogenesis of eczematous lesions of atopic dermatitis

Shaker, Olfat G.; El-Komy, Mohamed H.M.; Tawfic, Shereen O.; Zeid, Ahmed; Tomairek, R.H.

doi:10.1016/j.jdermsci.2008.08.018

Cited by 6 publications

(3 citation statements)

References 9 publications

(12 reference statements)

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“…Our results confirm that IL-18 may be a clinical marker of disease severity, consistent with some of the previous studies; 10,20,24 however, other studies 8,23 found no correlation between SCORAD score and IL-18 levels. Our data also confirmed that SCORAD score correlates with IgE level, again consistent with previous observations.…”

Section: Discussionsupporting

confidence: 92%

“…An association between SCORAD score and IL‐18 levels has been reported previously in studies on Turkish, 9 Japanese, 11 Chinese 20 and Korean 24 populations. IL‐18 level was found to be higher in the sera of patients with AD than of controls in Turkish, 9 Chinese, 20 Japanese 11,21 African 23 and Korean 8,24 populations. We found similar results with our study, which is the largest to date and on a predominantly white population (Table 1).…”

Section: Discussionmentioning

confidence: 90%

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Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis

Trzeciak

Gleń

Bandurski

et al. 2011

Clinical and Experimental Dermatology

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis

Trzeciak

Gleń

Bandurski

et al. 2011

Clinical and Experimental Dermatology

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“…We and others have previously shown that the plasma level of IL-18, a product of activation of the inflammasome, is increased in AE patients [20], [21], [22]. In addition, the expression of IL-18 has been found to be increased in inflamed skin [23].…”

Section: Resultsmentioning

confidence: 79%

The Expression of BAFF, APRIL and TWEAK Is Altered in Eczema Skin but Not in the Circulation of Atopic and Seborrheic Eczema Patients

et al. 2011

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The TNF family cytokines BAFF (B-cell activating factor of the TNF family) and APRIL (a proliferation-inducing ligand) are crucial survival factors for B-cell development and activation. B-cell directed treatments have been shown to improve atopic eczema (AE), suggesting the involvement of these cytokines in the pathogenesis of AE. We therefore analyzed the expression of these TNF cytokines in AE, seborrheic eczema (SE) and healthy controls (HC). The serum/plasma concentration of BAFF, APRIL and a close TNF member TWEAK (TNF-like weak inducer of apoptosis) was measured by ELISA. The expression of these cytokines and their receptors in skin was analyzed by quantitative RT-PCR and immunofluorescence. Unlike other inflammatory diseases including autoimmune diseases and asthma, the circulating levels of BAFF, APRIL and TWEAK were not elevated in AE or SE patients compared with HCs and did not correlate with the disease severity or systemic IgE levels in AE patients. Interestingly, we found that the expression of these cytokines and their receptors was altered in positive atopy patch test reactions in AE patients (APT-AE) and in lesional skin of AE and SE patients. The expression of APRIL was decreased and the expression of BAFF was increased in eczema skin of AE and SE, which could contribute to a reduced negative regulatory input on B-cells. This was found to be more pronounced in APT-AE, the initiating acute stage of AE, which may result in dysregulation of over-activated B-cells. Furthermore, the expression levels of TWEAK and its receptor positively correlated to each other in SE lesions, but inversely correlated in AE lesions. These results shed light on potential pathogenic roles of these TNF factors in AE and SE, and pinpoint a potential of tailored treatments towards these factors in AE and SE.

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A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type

Kabashima-Kubo

Nakamura

Sakabe

et al. 2012

Journal of Dermatological Science

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Possible role of nerve growth factor and interleukin-18 in pathogenesis of eczematous lesions of atopic dermatitis

Cited by 6 publications

References 9 publications

Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis

Relationship between serum levels of interleukin-18, IgE and disease severity in patients with atopic dermatitis

The Expression of BAFF, APRIL and TWEAK Is Altered in Eczema Skin but Not in the Circulation of Atopic and Seborrheic Eczema Patients

A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: Possible immunological state of the intrinsic type

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