Possible role of more positive social behaviour in the clinical effect of antidepressant drugs

Young, Simon N.; Moskowitz, D. S.; Rot, Marije aan het

doi:10.1503/jpn.130165

Cited by 26 publications

(25 citation statements)

References 68 publications

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“…Increased communal and agentic behaviour is consistent with the Social Interaction Model, which suggests that symptom improvement may result from improved interpersonal behaviour and, subsequently, reduced negative interpersonal consequences. 24 Evidence of increased perception of warmth in others' behaviour, along with improved affect, supports the Cognitive Neuropsychological Model, in which serotonergic medication impacts on mood and symptomatology by modifying cognitions, such as the tendency to perceive others as acting in a quarrelsome manner. 27,28 Previous support for both theories has been limited to research in healthy community participants or laboratorybased research.…”

Section: Discussionmentioning

confidence: 80%

“…The Social Interaction Model proposed by Young and colleagues 23 focuses on depression and suggests that serotonergic medication increases prosocial behaviour and reduces instability, thereby improving social interactions that reduce symptomatology. 24 Among healthy volunteers, research has documented changes in interpersonal behaviour [13][14][15]18,25 and participant-reported interpersonal problems 26 during the administration of serotonergic medications. Harmer and colleagues 27,28 summarized evidence supporting a cognitive neuropsychological model, in which serotonergic medication facilitates changes in attention and memory that reduce cognitive biases.…”

Section: Introductionmentioning

confidence: 99%

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Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study

Rappaport

Russell

Hedeker

et al. 2018

jpn

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Background: Laboratory-based research with community samples has suggested changes in affective, behavioural and cognitive processes as possible explanations for the effects of serotonergic medications. Examining the effects of serotonergic medications using an ecological momentary measure (such as event-contingent recording) in the daily lives of people with social anxiety disorder would contribute to establishing the effects of these medications on affect, behaviour and one form of cognition: perception of others' behaviour. Methods: The present study assessed changes in affect, interpersonal behaviour and perception of others' behaviour in adults with social anxiety disorder using ecological momentary assessment at baseline and over 4 months of a single-arm, uncontrolled, open-label trial of treatment with the selective serotonin reuptake inhibitor paroxetine. Results: Anxiety and concurrent depressive symptoms decreased. Participants also reported increased positive and decreased negative affect; increased agreeable and decreased quarrelsome behaviour; increased dominant and decreased submissive behaviour; and increased perception that others behaved agreeably toward them. Moreover, participants demonstrated reduced intraindividual variability in affect, interpersonal behaviour and perception of others' behaviour. Limitations: Limitations included the lack of a placebo group, the inability to identify the temporal order of changes and the restricted assessment of extreme behaviour. Conclusion: The results of the present study demonstrate changes during pharmacotherapy in the manifestation of affect, interpersonal behaviour and interpersonal perception in the daily lives of people with social anxiety disorder. Given the importance of interpersonal processes to social anxiety disorder, these results may guide future research seeking to clarify mechanisms of action for serotonergic medications. Affiliations:

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Section: Discussionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study

Rappaport

Russell

Hedeker

et al. 2018

jpn

View full text Add to dashboard Cite

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“…As mentioned in the Introduction, Young and colleagues (2014) recently proposed that serotonergic antidepressants in depressed individuals might work by acutely promoting more positive social behavior and that this will gradually result in mood improvement. This idea was largely based on a previous study in individuals with high trait quarrelsomeness, who are also thought to be at risk for MDD ( Conner et al, 2003 ).…”

Section: Discussionmentioning

confidence: 99%

The Effects of Tryptophan on Everyday Interpersonal Encounters and Social Cognitions in Individuals with a Family History of Depression

Hogenelst

Schoevers

Rot

2015

International Journal of Neuropsychopharmacology

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Background:Individuals with a family history of depression show subtle abnormalities in the processing of social stimuli. This could negatively affect their interpersonal functioning and contribute to their depression risk. Repeated administration of the serotonin precursor tryptophan has previously been shown to increase agreeable behavior and reduce quarrelsome behavior in irritable people, who are also considered at risk for depression.Methods:To examine the effects of tryptophan on social functioning in individuals with a family history of depression, 40 men and women with at least one first-degree relative with depression received tryptophan (1g three times a day) and placebo for 14 days each in a double-blind crossover design and recorded their social behavior and mood during everyday interpersonal encounters. Participants also provided daily ratings of their positive and negative cognitions concerning their social functioning.Results:Tryptophan improved mood. Unexpectedly, tryptophan increased quarrelsome behavior and reduced agreeable behavior, specifically during interactions at home. The behavioral effects of tryptophan were not moderated by mood or by the interaction partner. Negative social cognitions were lower when tryptophan was given second and lower during placebo when placebo was given second.Conclusion:Overall, tryptophan may not alter social behavior in individuals with a family history of depression as it does in irritable people. However, the behavioral effects of tryptophan at home might be seen as a way for individuals with a family history of depression to achieve more control. Over time, this may positively influence the way they feel and think about themselves in a social context.

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“…However, it may be anticipated, for example, that more motivated patients may be more adherent to their medication or may be more prone to develop more positive social interactions. 33 It is possible that motivation is also associated with more rapid spontaneous recovery from depressive episodes in the absence of treatment but, again, this cannot be addressed in studies such as ours.…”

Section: Discussionmentioning

confidence: 80%

The ability of early changes in motivation to predict later antidepressant treatment response

Gorwood

Vaïva

Llorca³

et al. 2015

NDT

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IntroductionBaseline values and early changes of emotional reactivity, cognitive speed, psychomotor function, motivation, and sensory perception have not been studied to any extent in unipolar depression, although they could help to characterize different dimensions of illness that are harder to capture by clinicians, give new insights on how patients improve, and offer new early clinical markers for later treatment response.MethodsAbout 1,565 adult outpatients with major depressive disorder receiving agomelatine completed the clinician-rated 16-item quick inventory of depressive symptoms, Clinical Global Impression, and Multidimensional Assessment of Thymic States (MAThyS) rating scales at inclusion, Week 2 and Week 6. The MAThyS includes a 20-item self-rated visual analog scale (from inhibition [0] to activation [10], with [5] representing the usual state) leading to five a priori dimensions (emotional reactivity, cognitive speed, psychomotor function, motivation, and sensory perception).ResultsAll MAThyS dimension scores increased from inclusion to Week 2 and from inclusion to Week 6 (P<0.001). Improvement was around 2 points (out of 10) for motivation, 1.5 points for psychomotor function, and 0.5 points for other dimensions. Motivation showed a trend to being more severely impaired at inclusion in future nonresponders (t=1.25, df=1,563, P=0.10). Its improvement at Week 2 was the most discriminating MAThyS dimension between future responders and nonresponders, and represents the best predictor of future response, with the highest area under the receptor operating characteristic curve (area under curve =0.616, 95% confidence interval [0.588–0.643], P<0.001). Finally, improvements in motivation correlated the most strongly with clinician-rated 16-item quick inventory of depressive symptoms improvement (r=−0.491, df=1,563, P<0.001).ConclusionMotivation had the most capacity for early improvement, the best predictive value for response, and the largest global margin of progress in depressed outpatients. Assessing the evolution of self-reported motivation over time in major depressive disorder could offer an interesting complementary approach to predict response.

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Possible role of more positive social behaviour in the clinical effect of antidepressant drugs

Cited by 26 publications

References 68 publications

Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study

Affect, interpersonal behaviour and interpersonal perception during open-label, uncontrolled paroxetine treatment of people with social anxiety disorder: a pilot study

The Effects of Tryptophan on Everyday Interpersonal Encounters and Social Cognitions in Individuals with a Family History of Depression

The ability of early changes in motivation to predict later antidepressant treatment response

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