Possible role of leptin, and tumor necrosis factor-alpha in hypoandrogenicity in patients with early rheumatoid arthritis

Ismail, Faten; Ali, Hisham; Ibrahim, Hanaa

doi:10.1016/j.ejr.2011.07.006

Cited by 14 publications

(6 citation statements)

References 25 publications

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“…Within the studied population, resistin levels were higher in patients with RAPID3 near remission, and adiponectin, vaspin, and leptin were lower in patients with DAS28-ESR in remission. RAPID3 had a weak correlation with adipsin, and the PCA showed the relation of adipsin and leptin with RAPID3, as reported by other groups [19][20][21].…”

Section: Discussionsupporting

confidence: 80%

“…However, it is worth emphasizing that all our patients received conventional treatment. One of this study's strengths is that, to our knowledge, it is one of the first to analyze a broad array of adipokines in patients with eRA in the Latin American population and has validated findings from a study previously carried out by our group [19]. Given that we did not identify another similar study of a Colombian population, the results of the cutoff points provide essential information to be analyzed in subsequent studies.…”

Section: Study Limitationsmentioning

confidence: 87%

“…However, the PCA revealed an association with cholesterol and vaspin and an inverse association with acute phase reactants. Ismail et al [19] reported a correlation between leptin and the disease activity indices measured by DAS28.…”

Section: Discussionmentioning

confidence: 97%

“…Currently, disparities exist regarding the definition of the time from diagnosis and the onset of symptoms to diagnosis. The selected time was less than two years, although other definitions use less than one year [18][19][20][24][25][26][27][28][29] and even less than six months in other populations [30,31]. The recent findings could lead to considering the measurement of adipokines as an early marker associated with the activity.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity

Chamorro-Melo¹,

Calixto²,

Bello-Gualtero³

et al. 2022

Reumatologia

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Introduction: Adipokines may play a role in the early stages of rheumatoid arthritis. This study evaluated the performance of adipokines in a Colombian population with early rheumatoid arthritis and its relationship with disease activity. Material and methods: A cross-sectional study evaluated serum adipokine levels (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis (eRA), evaluating demographic and clinical variables, along with a control group matched by age and gender. A factorial analysis was performed using principal components analysis (PCA), and a Spearman correlation analysis was performed. Similarly, a cut-off point for serum levels is proposed based on the receiver operating characteristic (ROC) curve between eRA and controls and sensitivity analysis.Results: Fifty-one eRA subjects were included; there were 41 women. The body mass index (BMI) was 25.12 ±3.8. A statistically significant correlation was identified between adipsin, BMI, and RAPID3. Vaspin and leptin were correlated with BMI. Resistin levels were higher in patients with RAPID3 near remission (p = 0.041), and adiponectin, vaspin, and leptin levels were lower in patients with DAS28 ESR in remission (p = 0.033, p = 0.012, and p = 0.017, respectively). Principal components analysis in component 1 adipokines as adipsin and leptin with BMI and RAPID3 as disease activity index are grouped. Moreover, component 2 had a strong relation between ESR and CRP with an inverse correlation with cholesterol levels and vaspin. A cut-off point was established for each adipokine, thus identifying the best performance for leptin levels greater than 0.58 ng/ml with a sensitivity of 76.5% and specificity of 74.5%. Conclusions: Adipokine levels are relevant in eRA, especially with disease activity indexes. Resistin levels were higher in patients with an activity index near remission. Otherwise, adiponectin, vaspin, and leptin levels were lower in patients with low activity indexes. RAPID3 correlated with adipsin. It is complementary to the previously published analysis of adipokines.

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Section: Discussionsupporting

confidence: 80%

Section: Study Limitationsmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity

Chamorro-Melo¹,

Calixto²,

Bello-Gualtero³

et al. 2022

Reumatologia

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show abstract

“…Interleukin-1 (IL-1), Interleukin-6 (IL-6), Interleukin-8 (IL-8), JAK 1/2/3, and Granulocyte-macrophage colony-stimulating factors are all autocrine stimulators and paracrine inducers for this cytokine. It also boosts the proliferation of a wide range of cells, including macrophages, activated T-cells, Bcells, synovial cells, and endothelial and fibroblast cells, as well as induces the production of adhesion molecules [3].…”

Section: Introductionmentioning

confidence: 99%

In Silico Prediction of Essentials Oil From Cymbopogon Nardus as Immunomodulator in Rheumatoid Arthritis

et al. 2022

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Objective: Rheumatoid arthritis (RA) is an autoimmune disease involving the synovial lining of the major joints. Our study involves bioactive compounds of Cymbopogon Nardus as possible Rheumatoid arthritis drugs in silico targeted TNF-α, JAK1/2, JAK3, PAD4, and DHFR. Methods: Using computational docking and receptors from the Protein Data Bank (PDB) files 2AZ5, 3EYG, 3LXY, 1DLS, and 1WDA. Molegro Virtual Docker 6.0 was utilized to undertake an in silico anti-arthritis drugs study. ChemDraw 3D was utilized to minimize the ligand's energy before docking, and the structures Native Ligand were employed as positive control medications. A pharmacokinetic and toxicological study was performed using SwissADME (ADME) and PK-CMS. Results: Using the Moldock SE mechanism calculates the binding (atom) energies of each protein (Enzyme) and each ligand at the least energetic conformation state. Docking results of ten tested bioactive compounds have not displayed the Lowest rerank score scores and best fit within the prominent active site residues. Conclusion: The Essentials oils from Cymbopogon nardus have not effectively suppressed the Rheumatoid Arthritis pathway through inhibition of TNF-α, JAK1/2, JAK3, PAD4, and DHFR which can serve as potential lead compounds for the development of new drugs for the treatment of Rheumatoid Arthritis.

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Rheumatology in Egypt: back to the future

Gheita

Eesa

2018

Rheumatol Int

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Possible role of leptin, and tumor necrosis factor-alpha in hypoandrogenicity in patients with early rheumatoid arthritis

Cited by 14 publications

References 25 publications

Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity

Evaluation of the adipokine profile (adiponectin, resistin, adipsin, vaspin, and leptin) in patients with early rheumatoid arthritis and its correlation with disease activity

In Silico Prediction of Essentials Oil From Cymbopogon Nardus as Immunomodulator in Rheumatoid Arthritis

Rheumatology in Egypt: back to the future

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