Possible role of hyposensitivity of C‐fiber afferents at the proximal urethra in the development of urge urinary incontinence in patients with detrusor overactivity

Ichiyanagi, Osamu; Nagaoka, Akira; Naito, Sei; Tsukigi, Masaaki; Yagi, Mayu; Kato, Tomoyuki; Ishigooka, Manabu; Tsuchiya, Norihiko

doi:10.1111/luts.12206

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…Out of 80 studies, 61 exclusively applied CPTs [6,7,13–71], but four reported incomplete or no CPT results [14,32,61,64] (Table S2).…”

Section: Resultsmentioning

confidence: 99%

“…In non-neurogenic overactive bladder (OAB) patients, results were more conflicting, as some studies demonstrated higher LUTCPTs in patients with OAB compared to controls [19,33], while other studies showed no difference [25,34] or decreased LUTCPTs [35]. Patients with stress urinary incontinence have been reported to show elevated CPTs compared to controls [36], with no difference compared to patients with OAB [25].…”

Section: Patients With Luts/lutdmentioning

confidence: 99%

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Lower urinary tract electrical sensory assessment: a systematic review and meta‐analysis

et al. 2021

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To summarize the current literature on lower urinary tract electrical sensory assessment (LUTESA), with regard to current perception thresholds (CPTs) and sensory evoked potentials (SEPs), and to discuss the applied methods in terms of technical aspects, confounding factors, and potential for lower urinary tract (LUT) diagnostics. MethodsThe review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Medline (PubMed), Embase and Scopus were searched on 13 October 2020. Meta-analyses were performed and methodological qualities of the included studies were defined by assessing risk of bias (RoB) as well as confounding. ResultsAfter screening 9925 articles, 80 studies (five randomized controlled trials [RCTs] and 75 non-RCTs) were included, comprising a total of 3732 patients and 692 healthy subjects (HS). Of these studies, 61 investigated CPTs exclusively and 19 reported on SEPs, with or without corresponding CPTs. The recording of LUTCPTs and SEPs was shown to represent a safe and reliable assessment of LUT afferent nerve function in HS and patients. LUTESA demonstrated significant differences in LUT sensitivity between HS and neurological patients, as well as after interventions such as pelvic surgery or drug treatments. Pooled analyses showed that several stimulation variables (e.g. stimulation frequency, location) as well as patient characteristics might affect the main outcome measures of LUTESA (CPTs, SEP latencies, peak-to-peak amplitudes, responder rate). RoB and confounding was high in most studies. ConclusionsPreliminary data show that CPT and SEP recordings are valuable tools to more objectively assess LUT afferent nerve function. LUTESA complements already established diagnostics such as urodynamics, allowing a more comprehensive patient evaluation. The high RoB and confounding rate was related to inconsistency and inaccuracy in reporting rather than the technique itself. LUTESA standardization and well-designed RCTs are crucial to implement LUTESA as a clinical assessment tool.

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“…Out of 80 studies, 61 exclusively applied CPTs [6,7,13–71], but four reported incomplete or no CPT results [14,32,61,64] (Table S2).…”

Section: Resultsmentioning

confidence: 99%

Section: Patients With Luts/lutdmentioning

confidence: 99%

Lower urinary tract electrical sensory assessment: a systematic review and meta‐analysis

et al. 2021

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Urethral Sensation

Wyndaele

2022

Sensation in the Pelvic Region

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Possible role of hyposensitivity of C‐fiber afferents at the proximal urethra in the development of urge urinary incontinence in patients with detrusor overactivity

Abstract: Hyposensitive C-fibers of the proximal urethra may contribute to the development of urodynamic DO as well as UUI in patients complaining of lower urinary tract symptoms.

Cited by 2 publications

References 33 publications

Lower urinary tract electrical sensory assessment: a systematic review and meta‐analysis

Lower urinary tract electrical sensory assessment: a systematic review and meta‐analysis

Urethral Sensation

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