Possible role of C60 fullerene in the induction of reproductive toxicity in the freshwater fish, Anabas testudineus (Bloch, 1792)

Sumi, N.; Chitra, K. C.

doi:10.1007/s11356-020-08509-6

Cited by 14 publications

(6 citation statements)

References 62 publications

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“…Triclosan exposure reduced the body weight, brain tissue weight, and absolute and relative weights of gonads in a concentration-dependent manner on both sexes when compared with the respective control groups thereby illustrating the systemic effects of the toxicant. In most ecotoxicological studies, the evaluation of body weights and tissue weights are considered one of the most sensitive indicators of toxicant exposure where these changes are associated with treatment-related anorexia and/or cellular and tissue damages (Bailey et al, 2004; Sumi and Chitra, 2020). The gonadosomatic index or the relative weight of the gonads is considered a good indicator to measure reproductive activity upon exposure to estrogenic compounds (Sumi and Chitra, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…In most ecotoxicological studies, the evaluation of body weights and tissue weights are considered one of the most sensitive indicators of toxicant exposure where these changes are associated with treatment-related anorexia and/or cellular and tissue damages (Bailey et al, 2004; Sumi and Chitra, 2020). The gonadosomatic index or the relative weight of the gonads is considered a good indicator to measure reproductive activity upon exposure to estrogenic compounds (Sumi and Chitra, 2020). Triclosan exposure significantly affected the gonadosomatic index in both sexes consistent with a previous study after sublethal exposure of chlordecone for 30 days to the cichlid fish, Pseudetroplus maculatus (Asifa and Chitra, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792)

Chokki Veettil,

Nikarthil Sidhick,

Kavungal Abdulkhader

et al. 2024

Toxicol Ind Health

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Triclosan (TCS), an antimicrobial drug, is known to occupy different compartments in aquatic ecosystems. The present study focused to evaluate the reproductive toxicity of triclosan, at environmentally relevant (0.009 and 9 μg L−1) and sublethal (176.7 μg L−1) concentrations for 90 days in the pre-spawning phase of the fish, Anabas testudineus. The reproductive biomarkers, namely, gonadal steroidogenic enzymes, expression of aromatic genes, levels of serum gonadotropins, sex hormones, and histology of gonads were analyzed. The weight of the animal, brain weights along with gonadosomatic index decreased while mucus deposition increased significantly at all concentrations of triclosan as the primary defensive mechanism to prevent the entry of toxicants. Triclosan disrupted gonadal steroidogenesis as evidenced by a reduction in the activities of gonadal steroidogenic enzymes. The expressions of cyp19a1a and cyp19a1b genes were up-regulated in the brain of both sexes and testis, while down-regulated in the ovary indicating estrogenic effects of the compound. The endocrine-disrupting effects of triclosan were confirmed. The current results suggest that chronic exposure to triclosan altered reproductive endpoints thereby impairing normal reproductive functions in fish.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792)

Chokki Veettil,

Nikarthil Sidhick,

Kavungal Abdulkhader

et al. 2024

Toxicol Ind Health

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“…In this study, triclosan exposure increased the mucous deposition throughout the body of the fish indicating the primary defensive mechanism to prevent the entry of the toxicant. Such a first line of defence has been exhibited by the fishes against various other chemical stressors such as phthalate plasticizers and nanomaterials (Sruthi et al, 2020;Sumi and Chitra, 2020). Other biometric parameters such as weights of gonads, liver, gonadosomatic index (GSI) and hepato-somatic index (HSI) are important indicators used in this study to evaluate gonadal development and reproductive activity along with the involvement of the liver in vitellogenesis (Sadekarpawar and Parikh, 2013;Pandit and Gupta, 2019).…”

Section: Discussionmentioning

confidence: 99%

Triclosan Influences on Reproductive Physiology of Climbing Perch in the Spawning Phase

Priyatha

Chitra

2022

Croatian Journal of Fisheries

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The endocrine-disrupting effects of triclosan, an antimicrobial agent, and its involvement in reproductive responses mediated through different modes of activity in various fish species have been documented. The present study aims to explore whether triclosan at environmentally relevant and sublethal concentrations could influence the reproductive physiology of the fish Anabas testudineus in the spawning phase. Fish were exposed to triclosan at environmentally relevant (0.009 and 9 µg L−1) and sublethal (176.7 µg L−1) concentrations for 4, 7, 30 and 60 d during the spawning phase for evaluating the reproductive potential of the fish. Triclosan exposure caused a significant (P<0.05) reduction in the level of total protein in gonads and liver tissues while increasing blood plasma to meet the energy demand and overcome metabolic stress. Impairment in gonadal steroidogenesis was evidenced by the reduction in the activities of 3β- and 17β-hydroxysteroid dehydrogenases associated with alteration in the levels of serum gonadotropins, sex steroid hormones and vitellogenin. Triclosan exposure caused a reduction in the rate of fecundity in females and declined sperm counts, motility and viability in males. Histological lesions in gonadal tissues further confirmed the reproductive toxicity of triclosan, which in turn could contribute to the reproductive failure of the fish.

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“…The serum testosterone and estradiol showed a significant decrement in male and female fish, respectively, in concentration-and time-dependent manners. The study suggested stress-induced by C60 exposure provoked reproductive toxicity in Anabas testudineus [56]. In a similar study protocol, the toxic effect of C60 was evaluated on behavioral and hematological changes in freshwater fish Anabas testudineus at 5 and 10 mg/L for 96 h and 60 days.…”

Section: Fullerene Biological Interaction Bioavailability Toxicity mentioning

confidence: 99%

An Update Report on the Biosafety and Potential Toxicity of Fullerene-Based Nanomaterials toward Aquatic Animals

Malhotra¹,

Ger²,

Castillo³

et al. 2020

Preprint

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Fullerene molecules are composed of carbon in forms of a hollow sphere, ellipsoid, or tube. Fullerenes have attracted considerable attention in different fields of science since their discovery in 1985. The unique carbon cage structure of fullerene provides immense scope for derivatization, rendering potential for various industrial applications. The prospective applications of fullerenes thus have led to assorted fullerene derivatives. The unique chemical structure also provides ease for fullerene to be synthesized through various kinds of conjugating techniques, where fullerene can be located either on the backbone or the branch chain. Here in this review, we have compiled the toxicity and biosafety aspects of fullerene in aquatic organisms. The frequent use of fullerene is likely to come in contact and interact with the aquatic environment and aquatic organisms. According to the current understanding, waterborne exposure to fullerene-based nanomaterials indeed triggers toxicities at cellular, organic, molecular as well as neurobehavioral levels.

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Possible role of C60 fullerene in the induction of reproductive toxicity in the freshwater fish, Anabas testudineus (Bloch, 1792)

Cited by 14 publications

References 62 publications

Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792)

Triclosan, an antimicrobial drug, induced reproductive impairment in the freshwater fish, Anabas testudineus (Bloch, 1792)

Triclosan Influences on Reproductive Physiology of Climbing Perch in the Spawning Phase

An Update Report on the Biosafety and Potential Toxicity of Fullerene-Based Nanomaterials toward Aquatic Animals

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