Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits

Akyol, Sümeyya; Yüksel, Sevda; Pehlivan, Sultan; Erdemli, Hacı Kemal; Güleç, Mehmet Akif; Adam, Bahattin; Akyol, Ömer

doi:10.1016/j.mehy.2016.04.015

Cited by 5 publications

(3 citation statements)

References 29 publications

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“…Therefore, it is possible to measure oxygen radicals and lipid peroxidation level in the brain tissue via serum MDA content. The observations of the present study were consistent with the hypothesis that reactive oxygen species (ROS) may be associated with the acute toxic effects of CO on the central nervous system ( 8 ). Additionally, a sudden burst of ROS during ischemic-reperfusion injury in CO toxicity leads to cellular lipid peroxidation, and thus MDA may increase in acute CO poisoning.…”

Section: Discussionsupporting

confidence: 91%

“…In addition, dexamethasone and hypertonic glucose dehydration therapy are often used to prevent or treat delayed encephalopathy ( 7 ); however these treatments act only as symptomatic therapies or are used to prevent CO poisoning complications. A recent hypothesis indicated that an antioxidant such as caffeic acid phenethyl ester and anti-nitric oxide therapy may be valuable for neuroprotection against CO poisoning ( 8 ). Thus far, the majority of research studies ( 9 – 11 ) have focused on the treatment for delayed encephalopathy caused by CO poisoning, whereas few ( 12 ) have reported the emergency treatment for CO poisoning.…”

Section: Introductionmentioning

confidence: 99%

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A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice

Shi

Wen

et al. 2017

Exp Ther Med

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There is no effective drug for the therapy of acute carbon monoxide (CO) poisoning. The purpose of the present study was to investigate the potential preventive and therapeutic effects of hemin on an animal model of acute CO poisoning and to provide a potential therapeutic candidate drug. A total of 80 Kunming mice were randomly divided into four groups, namely the air control, acute CO poisoning, hemin-treatment + CO and hemin-pretreatment + CO groups (n=20 each). Furthermore, the mortality rate of mice, blood carboxyhaemoglobin (HbCO) concentration and serum malondialdehyde (MDA) concentration were measured, and pathological changes of the hippocampal area were determined using histochemical staining. The mice with acute CO poisoning had a 50% mortality rate at 1 h, with an increase in blood HbCO, serum MDA levels and pathological impairments of the hippocampus. Furthermore, the mortality rate, blood HbCO and serum MDA levels of mice with pretreatment and treatment of hemin were decreased. Additionally, the pathological changes of the hippocampal area were improved in the hemin-treatment and hemin-pretreatment groups compared with the mice treated with CO. These results suggest that hemin is a novel effective chemical for the prevention and treatment of acute CO poisoning in mice. Therefore, the present study provides a novel method and experimental basis for the application of hemin in treating patients with acute CO poisoning.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice

Shi

Wen

et al. 2017

Exp Ther Med

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“… 16 The mechanism of CO toxicity is not clear; however, if it results in oxidative stress, neuronal toxicity, and post ischemic reperfusion injury responsible for delayed symptoms, antioxidants may prove to be a novel treatment approach. 17 , 18 , 19 …”

Section: Discussionmentioning

confidence: 99%

Delayed neurologic sequelae of carbon monoxide intoxication

Sönmez

İşcanlı

Parlak

et al. 2018

Turkish Journal of Emergency Medicine

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Altered consciousness and accompanying neurological symptoms are both complex and challenging cases for emergency physicians. These are not specific and may be a sign of a variety of medical conditions including stroke and delayed neurological sequelae (DNS) is a recurrent transient neuropsychiatric consequence of CO intoxication. DNS produces a spectrum of varying symptoms and the diagnosis is primarily made on the basis of clinical features and radiological findings from CT and conventional MRI. In clinical practice, serious CO intoxication is treated only with oxygen therapy although no effective treatment exists. Emergency physicians play a major role in managing patients presenting with CO intoxication and preventing DNS.

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The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling

Liu

Yan

et al. 2019

J Mol Neurosci

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Possible role of antioxidants and nitric oxide inhibitors against carbon monoxide poisoning: Having a clear conscience because of their potential benefits

Cited by 5 publications

References 29 publications

A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice

A novel effective chemical hemin for the treatment of acute carbon monoxide poisoning in mice

Delayed neurologic sequelae of carbon monoxide intoxication

The Cannabinoid WIN 55,212-2 Reduces Delayed Neurologic Sequelae After Carbon Monoxide Poisoning by Promoting Microglial M2 Polarization Through ST2 Signaling

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