Possible role of anisotropic membrane inclusions in stability of torocyte red blood cell daughter vesicles

Fošnarič, Miha; Nemec, M.; Kralj‐Iglič, Veronika; Hägerstrand, Henry; Schara, M.; Iglič, Aleš

doi:10.1016/s0927-7765(02)00016-4

Cited by 12 publications

(5 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The single-inclusion energy can be taken as a starting point in the statistical mechanical derivation of the free energy of the pool of laterally mobile inclusions within the membrane. 52,53 If the lateral density of the inclusions is small enough, the single inclusion energy applied within the mean curvature field model 52 may be considered as a fair approximation. In this work we have considered cylindrical inclusions that are inserted in a flat membrane segment.…”

Section: Single Isolated Inclusionmentioning

confidence: 99%

Interaction between two cylindrical inclusions in a symmetric lipid bilayer

Bohinc

Kralj‐Iglič

May

2003

The Journal of Chemical Physics

Self Cite

View full text Add to dashboard Cite

We calculate the membrane-mediated interaction between two cylindrical inclusions in a symmetric lipid bilayer. Our theory takes two contributions to the free energy into account, the elastic behavior of the membrane and the conformational restrictions that the flexible hydrocarbon chains of the lipids experience in the vicinity of a rigid inclusion. The description of the elastic behavior is based on two order parameters, the hydrophobic thickness of the membrane and a director field that characterizes the average tilt of the lipid chains. Conformational restrictions of the lipid chains are taken into account by a simple director model. We show that the short-range interaction potential between two inclusions sensitively depends on the degree of hydrophobic mismatch and on the spontaneous curvature of the lipid layers. In particular, we find pronounced attraction if the hydrophobic mismatch is positive. For negative mismatch the attraction is much less pronounced and, additionally, an energetic barrier appears. The inclusions prefer a small but notable negative hydrophobic mismatch. Positive spontaneous curvature amplifies these behaviors.

show abstract

Section: Single Isolated Inclusionmentioning

confidence: 99%

Interaction between two cylindrical inclusions in a symmetric lipid bilayer

Bohinc

Kralj‐Iglič

May

2003

The Journal of Chemical Physics

Self Cite

View full text Add to dashboard Cite

show abstract

“…Physical properties and interactions within the nonlamellar phospholipid systems could be further elucidated from a viewpoint of recent theoretical results regarding the configuration of phospholipid molecules within membranous nanostructures. − Experiments have revealed high anisotropy in the curvature (a large difference between the two principal curvatures) in phospholipid bilayer nanotubules, − torocytic endovesicles of erythrocyte membranes, , phospholipid bilayer membrane pores, , and narrow necks of phospholipid bilayers connecting buds to the mother membrane . To explain the stability of these structures, a unifying theory was proposed based on the in-plane orientational ordering of phospholipid molecules in the local curvature field. − The curvature field at the given point in the membrane is determined by the neighboring phospholipid molecules.…”

Section: Introductionmentioning

confidence: 99%

Role of Phospholipid Asymmetry in the Stability of Inverted Hexagonal Mesoscopic Phases

Mareš¹,

Daniel²,

Perutková³

et al. 2008

J. Phys. Chem. B

Self Cite

View full text Add to dashboard Cite

The role of phospholipid asymmetry in the transition from the lamellar (L(alpha)) to the inverted hexagonal (H(II)) phase upon the temperature increase was considered. The equilibrium configuration of the system was determined by the minimum of the free energy including the contribution of the isotropic and deviatoric bending and the interstitial energy of phospholipid monolayers. The shape and local interactions of a single lipid molecule were taken into account. The minimization with respect to the configuration of the lipid layers was performed by a numerical solution of the system of the Euler-Lagrange differential equations and by the Monte Carlo simulated annealing method. At high enough temperature, the lipid molecules attain a shape exhibiting higher intrinsic mean and deviatoric curvatures, which fits better into the H(II) phase than into the L(alpha) phase. Furthermore, the orientational ordering of lipid molecules in the curvature field expressed as the deviatoric bending provides a considerable negative contribution to the free energy, which stabilizes the nonlamellar H(II) phase. The nucleation configuration for the L(alpha)-H(II) phase transition is tuned by the isotropic and deviatoric bending energies and the interstitial energy.

show abstract

“…For the sake of simplicity in this work all inclusions are ascribed to the outer lipid layer; however, it is not excluded that some types of inclusions (such as membrane integral proteins) may protrude through both lipid layers. Inclusions can move laterally over the phospholipid (bi)layer and also rotate around their axes normal to the membrane, so that they can find a place and orientation in the membrane that is energetically the most favorable [5,18]. Therefore, the equilibrium lateral distribution of inclusions in the membrane is in general non‐uniform.…”

Section: Theorymentioning

confidence: 99%

“…In the calculations, analysis is restricted to axisymmetric vesicle shapes with equatorial mirror symmetry. The vesicle shape is parameterized by a function of the form [5]

including four free parameters ( α , β , γ and δ ). The symmetry axis of the vesicle shape coincides with the y axis, so that the shape is given by rotation of the function y ( x ) around the y axis.…”

Section: Theorymentioning

confidence: 99%

See 1 more Smart Citation

Coupling between vesicle shape and the non‐homogeneous lateral distribution of membrane constituents in Golgi bodies

et al. 2004

Self Cite

View full text Add to dashboard Cite

In this work, a hypothesis is presented that could explain the non-homogeneous lateral distribution of membrane components in Golgi vesicles. It is shown that the non-homogeneous lateral distribution of membrane components and the specific flattened shape of Golgi vesicles are strongly coupled. In agreement with experimental evidence, it is indicated that some of the membrane components may be concentrated mainly on the curved bulbous rims of the Golgi vesicles, while the other components are distributed predominantly in their flat central part.

show abstract

Possible role of anisotropic membrane inclusions in stability of torocyte red blood cell daughter vesicles

Cited by 12 publications

References 33 publications

Interaction between two cylindrical inclusions in a symmetric lipid bilayer

Interaction between two cylindrical inclusions in a symmetric lipid bilayer

Role of Phospholipid Asymmetry in the Stability of Inverted Hexagonal Mesoscopic Phases

Coupling between vesicle shape and the non‐homogeneous lateral distribution of membrane constituents in Golgi bodies

Contact Info

Product

Resources

About